*************Generated from HitPredict database (15Jul2024)************* List of interactions for Q9NQC8|IFT46|Homo sapiens|Interactions:40 ************************************************************************ Interactor A ID Interactor B ID Interactor A Name Interactor B Name Interactor A Alias Interactor B Alias Interaction detection methods First author Publications Interactor A Taxonomy Interactor B Taxonomy Interaction type Source database Interaction identifier Confidence score uniprotkb:Q9NQC8 uniprotkb:Q86WT1 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IT70A_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:28514442|pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54807714 annotation-score:0.60|method-score:0.76|interaction-score:0.675 uniprotkb:Q9NQC8 uniprotkb:Q8N4P2 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IT70B_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:28514442|pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54807992 annotation-score:0.60|method-score:0.76|interaction-score:0.675 uniprotkb:Q9NQC8 uniprotkb:Q8WYA0 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT81_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)|psi-mi:MI:0676(tandem affinity purification) - pubmed:26186194|pubmed:28514442|pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.55|method-score:0.82|interaction-score:0.670 uniprotkb:Q9NQC8 uniprotkb:Q9NWB7 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT57_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:26186194|pubmed:28514442|pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54807954 annotation-score:0.55|method-score:0.80|interaction-score:0.664 uniprotkb:Q9NQC8 uniprotkb:Q96LB3 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT74_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:28514442|pubmed:33961781|pubmed:27173435 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.55|method-score:0.76|interaction-score:0.646 uniprotkb:Q9NQC8 uniprotkb:Q13099 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT88_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0096(pull down)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.60|method-score:0.68|interaction-score:0.640 uniprotkb:Q9NQC8 uniprotkb:A5D8V7 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:ODAD3_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:26186194|pubmed:28514442|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54699985 annotation-score:0.55|method-score:0.74|interaction-score:0.638 uniprotkb:Q9NQC8 uniprotkb:Q3KP44 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:ANR55_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:26186194|pubmed:28514442|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54778801 annotation-score:0.55|method-score:0.74|interaction-score:0.638 uniprotkb:Q9NQC8 uniprotkb:Q3SXY8 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:AR13B_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:26186194|pubmed:28514442|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54611564 annotation-score:0.55|method-score:0.74|interaction-score:0.638 uniprotkb:Q9NQC8 uniprotkb:Q9UG01 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IF172_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0096(pull down)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.60|method-score:0.67|interaction-score:0.635 uniprotkb:Q9NQC8 uniprotkb:A0AVF1 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT56_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.60|method-score:0.66|interaction-score:0.628 uniprotkb:Q9NQC8 uniprotkb:Q9P2H3 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT80_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.60|method-score:0.66|interaction-score:0.628 uniprotkb:Q9NQC8 uniprotkb:Q96AJ1 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:CLUA1_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:29615496|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.55|method-score:0.72|interaction-score:0.628 uniprotkb:Q9NQC8 uniprotkb:Q9BW83 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT27_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808038 annotation-score:0.55|method-score:0.67|interaction-score:0.608 uniprotkb:Q9NQC8 uniprotkb:Q9Y547 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT25_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0096(pull down)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:35271311 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-52334348 annotation-score:0.55|method-score:0.67|interaction-score:0.608 uniprotkb:Q9NQC8 uniprotkb:Q8IY31 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT20_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.55|method-score:0.66|interaction-score:0.602 uniprotkb:Q9NQC8 uniprotkb:Q9H7X7 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT22_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54807678 annotation-score:0.55|method-score:0.66|interaction-score:0.602 uniprotkb:Q9NQC8 uniprotkb:Q9Y366 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:IFT52_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:27173435|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.55|method-score:0.66|interaction-score:0.602 uniprotkb:Q9NQC8 uniprotkb:Q86VQ0 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:LCA5_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:26638075|pubmed:unassigned1272 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-11363336 annotation-score:0.55|method-score:0.54|interaction-score:0.547 uniprotkb:Q9NQC8 uniprotkb:P52429 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:DGKE_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification) - pubmed:27173435 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-12450597 annotation-score:0.55|method-score:0.48|interaction-score:0.513 uniprotkb:Q9NQC8 uniprotkb:Q2M329 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:CF184_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54502874 annotation-score:0.55|method-score:0.48|interaction-score:0.513 uniprotkb:Q9NQC8 uniprotkb:Q8TDR0 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:MIPT3_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54808370 annotation-score:0.55|method-score:0.48|interaction-score:0.513 uniprotkb:Q9NQC8 uniprotkb:Q9BY84 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:DUS16_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54505762 annotation-score:0.55|method-score:0.48|interaction-score:0.513 uniprotkb:Q9NQC8 uniprotkb:Q96LJ8 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:UBX10_HUMAN(gene name) - - psi-mi:MI:0096(pull down) - pubmed:26389662 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:1517094 annotation-score:0.55|method-score:0.42|interaction-score:0.480 uniprotkb:Q9NQC8 uniprotkb:Q9UF56 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:FXL17_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:31560077 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:2757874 annotation-score:0.55|method-score:0.39|interaction-score:0.460 uniprotkb:Q9NQC8 uniprotkb:O94761 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:RECQ4_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:29229926 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2531391 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:Q9NQC8 uniprotkb:P56945 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:BCAR1_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:33001583 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2875001 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:Q9NQC8 uniprotkb:Q6ZU80 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:CE128_HUMAN(gene name) - - psi-mi:MI:1313(proximity labelling technology) - pubmed:26638075 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1432002 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:Q9NQC8 uniprotkb:Q8N4C6 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:NIN_HUMAN(gene name) - - psi-mi:MI:1313(proximity labelling technology) - pubmed:28718761 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2621565 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:Q9NQC8 uniprotkb:Q96G01 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:BICD1_HUMAN(gene name) - - psi-mi:MI:1313(proximity labelling technology) - pubmed:28718761 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2621040 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:Q9NQC8 uniprotkb:Q9C0D3 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:ZY11B_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:35674692 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3492980 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:Q9NQC8 uniprotkb:Q9UJC3 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:HOOK1_HUMAN(gene name) - - psi-mi:MI:1313(proximity labelling technology) - pubmed:28718761 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2621343 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:Q9NQC8 uniprotkb:O60303 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:KATIP_HUMAN(gene name) - - psi-mi:MI:0676(tandem affinity purification) - pubmed:26714646 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-26582514 annotation-score:0.55|method-score:0.33|interaction-score:0.426 uniprotkb:Q9NQC8 uniprotkb:P48307 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:TFPI2_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54585295 annotation-score:0.16|method-score:0.48|interaction-score:0.279 uniprotkb:Q9NQC8 uniprotkb:Q53FD0 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:ZC21C_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54768504 annotation-score:0.16|method-score:0.48|interaction-score:0.279 uniprotkb:Q9NQC8 uniprotkb:Q8N961 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:ABTB2_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54458766 annotation-score:0.16|method-score:0.48|interaction-score:0.279 uniprotkb:Q9NQC8 uniprotkb:Q8N9I0 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:SYT2_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-54484390 annotation-score:0.16|method-score:0.48|interaction-score:0.279 uniprotkb:Q9NQC8 uniprotkb:Q8WWY3 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:PRP31_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification) - pubmed:27173435 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-12450597 annotation-score:0.16|method-score:0.48|interaction-score:0.279 uniprotkb:Q9NQC8 uniprotkb:P62256 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:UBE2H_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:38113892 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3646447 annotation-score:0.16|method-score:0.38|interaction-score:0.249 uniprotkb:Q9NQC8 uniprotkb:Q9UHA2 uniprotkb:IFT46_HUMAN(gene name) uniprotkb:S18L2_HUMAN(gene name) - - psi-mi:MI:1313(proximity labelling technology) - pubmed:35016035 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3700397 annotation-score:0.16|method-score:0.38|interaction-score:0.249 *************Service provided by Combinatics****************************