*************Generated from HitPredict database (15Jul2024)*************
List of interactions for Q8IPV3|Q8IPV3|Drosophila melanogaster|Interactions:45
************************************************************************
Interactor A ID	Interactor B ID	Interactor A Name	Interactor B Name	Interactor A Alias	Interactor B Alias	Interaction detection methods	First author	Publications	Interactor A Taxonomy	Interactor B Taxonomy	Interaction type	Source database	Interaction identifier	Confidence score
uniprotkb:Q8IPV3	uniprotkb:Q7KTD0	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7KTD0_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:649572	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:Q8IPV3	uniprotkb:M9MRE1	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:M9MRE1_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:647390	annotation-score:0.90|method-score:0.38|interaction-score:0.586
uniprotkb:Q8IPV3	uniprotkb:Q7JVN6	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7JVN6_DROME(gene name)	-	-	psi-mi:MI:0018(two hybrid)	-	pubmed:14605208	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-220532	annotation-score:0.60|method-score:0.43|interaction-score:0.508
uniprotkb:Q8IPV3	uniprotkb:Q9VHZ7	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q9VHZ7_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:38270169	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-52313249	annotation-score:0.50|method-score:0.48|interaction-score:0.489
uniprotkb:Q8IPV3	uniprotkb:A1A714	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:A1A714_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:651052	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:Q8IPV3	uniprotkb:O96692	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:O96692_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:650728	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:Q8IPV3	uniprotkb:Q95SI0	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q95SI0_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:651412	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:Q8IPV3	uniprotkb:Q95U21	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q95U21_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:651440	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:Q8IPV3	uniprotkb:P22700	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:ATC1_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:649175	annotation-score:0.55|method-score:0.38|interaction-score:0.458
uniprotkb:Q8IPV3	uniprotkb:Q4QQB9	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q4QQB9_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:646278	annotation-score:0.55|method-score:0.38|interaction-score:0.458
uniprotkb:Q8IPV3	uniprotkb:Q9V447	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:KRH2_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:651599	annotation-score:0.55|method-score:0.38|interaction-score:0.458
uniprotkb:Q8IPV3	uniprotkb:Q9VBU6	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q9VBU6_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:649568	annotation-score:0.55|method-score:0.38|interaction-score:0.458
uniprotkb:Q8IPV3	uniprotkb:Q9VK06	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q9VK06_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:651710	annotation-score:0.55|method-score:0.38|interaction-score:0.458
uniprotkb:Q8IPV3	uniprotkb:A1Z729	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:A1Z729_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:647060	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:Q8IPV3	uniprotkb:P08645	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:RAP1_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:654892	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:Q8IPV3	uniprotkb:P18489	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:SYB_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:646116	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:Q8IPV3	uniprotkb:Q7JYX2	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7JYX2_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:648989	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:Q8IPV3	uniprotkb:Q7K3K5	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7K3K5_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:647945	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:Q8IPV3	uniprotkb:Q7KY04	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7KY04_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:653041	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:Q8IPV3	uniprotkb:Q8MZG9	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q8MZG9_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:654937	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:Q8IPV3	uniprotkb:Q24568	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:NETB_DROME(gene name)	-	-	psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:25294943	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-9919289	annotation-score:0.50|method-score:0.33|interaction-score:0.407
uniprotkb:Q8IPV3	uniprotkb:A8JR92	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:MBD56_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:36180891	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:3529787	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:O18405	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:SURF4_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:653850	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:O44783	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:SPY_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:651978	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:O76767	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:ERD2_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:655512	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:P25158	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:OSKA_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:27923120	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2322246	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q1ECB1	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q1ECB1_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:649142	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q24319	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:OST48_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:655125	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q7K0X9	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7K0X9_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:648302	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q7K110	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7K110_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:652068	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q7K1R6	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q7K1R6_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:655453	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q7K1V5	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:JAGN_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:655798	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q8IR34	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q8IR34_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:653202	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q8STG9	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q8STG9_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:649897	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q8SY53	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q8SY53_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:655711	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q94920	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:VDAC_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:647352	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q95R82	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q95R82_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:647109	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q95RI5	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:FAXC_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:646486	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q9VBF0	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q9VBF0_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:648590	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q9VKD7	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:ZUC_DROME(gene name)	-	-	psi-mi:MI:1313(proximity labelling technology)	-	pubmed:36762624	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:3693624	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q9VUC6	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:FRL_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:646728	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q9VW70	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q9VW70_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:645867	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q9VWL0	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q9VWL0_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:648048	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:Q9VZL3	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:Q9VZL3_DROME(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:22036573	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:647362	annotation-score:0.16|method-score:0.38|interaction-score:0.249
uniprotkb:Q8IPV3	uniprotkb:A0A0B4KGY6	uniprotkb:Q8IPV3_DROME(gene name)	uniprotkb:NOVA_DROME(gene name)	-	-	psi-mi:MI:0096(pull down)	-	pubmed:25294943	taxid:7227(Drosophila melanogaster)	taxid:7227(Drosophila melanogaster)	psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-9952257	annotation-score:0.16|method-score:0.33|interaction-score:0.232
*************Service provided by Combinatics****************************