*************Generated from HitPredict database (15Jul2024)*************
List of interactions for P35568|IRS1|Homo sapiens|Interactions:103
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Interactor A ID	Interactor B ID	Interactor A Name	Interactor B Name	Interactor A Alias	Interactor B Alias	Interaction detection methods	First author	Publications	Interactor A Taxonomy	Interactor B Taxonomy	Interaction type	Source database	Interaction identifier	Confidence score
uniprotkb:P35568	uniprotkb:P06213	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:INSR_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0018(two hybrid)|psi-mi:MI:0415(enzymatic study)|psi-mi:MI:0401(biochemical)|psi-mi:MI:0006(anti bait coimmunoprecipitation)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:7499194|pubmed:25667086|pubmed:10455177|pubmed:8626379|pubmed:11781100|pubmed:11606564|pubmed:7935368|pubmed:17167487|pubmed:16582879|pubmed:8662806	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0471(mint)	mint:19010	annotation-score:1.00|method-score:0.94|interaction-score:0.971
uniprotkb:P35568	uniprotkb:P62993	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:GRB2_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0686(unspecified method)|psi-mi:MI:0254(genetic interference)|psi-mi:MI:0013(biophysical)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:8388384|pubmed:8491186|pubmed:12173038|pubmed:22974441|pubmed:8536716|pubmed:21706016|pubmed:7486683	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-3964621	annotation-score:1.00|method-score:0.93|interaction-score:0.963
uniprotkb:P35568	uniprotkb:P08069	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:IGF1R_HUMAN(gene name)	-	-	psi-mi:MI:0018(two hybrid)|psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:8895367|pubmed:8776723|pubmed:33991522|pubmed:10082579|pubmed:7559507|pubmed:7541045	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-2437601	annotation-score:1.00|method-score:0.86|interaction-score:0.929
uniprotkb:P35568	uniprotkb:Q8N122	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:RPTOR_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0096(pull down)	-	pubmed:16354680|pubmed:19561084|pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:721765	annotation-score:1.00|method-score:0.74|interaction-score:0.857
uniprotkb:P35568	uniprotkb:O60674	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:JAK2_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0415(enzymatic study)	-	pubmed:15316008|pubmed:9492017|pubmed:11208867	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:297612	annotation-score:1.00|method-score:0.70|interaction-score:0.834
uniprotkb:P35568	uniprotkb:P23458	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:JAK1_HUMAN(gene name)	-	-	psi-mi:MI:0415(enzymatic study)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:9492017|pubmed:7499365|pubmed:9233603	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0974(innatedb)	innatedb:116519	annotation-score:1.00|method-score:0.70|interaction-score:0.834
uniprotkb:P35568	uniprotkb:P45983	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:MK08_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0096(pull down)|psi-mi:MI:0018(two hybrid)	-	pubmed:10722755|pubmed:11606564	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:8578	annotation-score:1.00|method-score:0.65|interaction-score:0.807
uniprotkb:P35568	uniprotkb:P23443	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:KS6B1_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)|psi-mi:MI:0415(enzymatic study)	-	pubmed:23045529|pubmed:18498745	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:724505	annotation-score:1.00|method-score:0.64|interaction-score:0.799
uniprotkb:P35568	uniprotkb:P27986	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:P85A_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0096(pull down)|psi-mi:MI:0047(far western blotting)|psi-mi:MI:0018(two hybrid)|psi-mi:MI:0686(unspecified method)|psi-mi:MI:0013(biophysical)|psi-mi:MI:0397(two hybrid array)|psi-mi:MI:0729(luminescence based mammalian interactome mapping)|psi-mi:MI:1356(validated two hybrid)|psi-mi:MI:0006(anti bait coimmunoprecipitation)|psi-mi:MI:0007(anti tag coimmunoprecipitation)|psi-mi:MI:0415(enzymatic study)|psi-mi:MI:0019(coimmunoprecipitation)|psi-mi:MI:0107(surface plasmon resonance)|psi-mi:MI:0030(cross-linking study)|psi-mi:MI:0077(nuclear magnetic resonance)	-	pubmed:25814554|pubmed:17640984|pubmed:26839216|pubmed:16880210|pubmed:16230374|pubmed:1334490|pubmed:7935461|pubmed:1381348|pubmed:8175658|pubmed:9564850|pubmed:8628286|pubmed:30240640|pubmed:29526746|pubmed:25273559|pubmed:7659087|pubmed:8388384|pubmed:12173038|pubmed:12730242|pubmed:12107746|pubmed:33991522|pubmed:14511371|pubmed:16354680|pubmed:15514089|pubmed:19561084|pubmed:22974441|pubmed:23439647|pubmed:7486683|pubmed:14632132|pubmed:unassigned1126|pubmed:23643389|pubmed:16150444|pubmed:11403293|pubmed:11416002|pubmed:7680095|pubmed:7680644|pubmed:8382612	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)|psi-mi:MI:0914(association)	psi-mi:MI:0471(mint)	mint:8036617	annotation-score:0.60|method-score:0.99|interaction-score:0.769
uniprotkb:P35568	uniprotkb:P31749	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:AKT1_HUMAN(gene name)	-	-	psi-mi:MI:0415(enzymatic study)|psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:17640984|pubmed:10497255	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:318011	annotation-score:1.00|method-score:0.59|interaction-score:0.768
uniprotkb:P35568	uniprotkb:Q05655	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:KPCD_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0415(enzymatic study)	-	pubmed:12031982|pubmed:15516986	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:471170	annotation-score:1.00|method-score:0.59|interaction-score:0.768
uniprotkb:P35568	uniprotkb:Q13322	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:GRB10_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:8621530|pubmed:12783867	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:691552	annotation-score:1.00|method-score:0.59|interaction-score:0.768
uniprotkb:P35568	uniprotkb:P52333	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:JAK3_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:7499365|pubmed:9233603	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0974(innatedb)	innatedb:116520	annotation-score:1.00|method-score:0.57|interaction-score:0.754
uniprotkb:P35568	uniprotkb:P42336	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PK3CA_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)|psi-mi:MI:0006(anti bait coimmunoprecipitation)|psi-mi:MI:0096(pull down)	-	pubmed:27684187|pubmed:34591612|pubmed:16354680|pubmed:14511371|pubmed:12933652|pubmed:23604317|pubmed:34591642|pubmed:23643389|pubmed:16150444	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0471(mint)	mint:8284879	annotation-score:0.60|method-score:0.94|interaction-score:0.752
uniprotkb:P35568	uniprotkb:O14920	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:IKKB_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)|psi-mi:MI:0423(in-gel kinase assay)	-	pubmed:12351658	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0217(phosphorylation reaction)	psi-mi:MI:0974(innatedb)	innatedb:113876	annotation-score:1.00|method-score:0.56|interaction-score:0.747
uniprotkb:P35568	uniprotkb:O15111	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:IKKA_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)|psi-mi:MI:0423(in-gel kinase assay)	-	pubmed:12351658	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0217(phosphorylation reaction)	psi-mi:MI:0974(innatedb)	innatedb:115814	annotation-score:1.00|method-score:0.56|interaction-score:0.747
uniprotkb:P35568	uniprotkb:Q9NRF2	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:SH2B1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0686(unspecified method)	-	pubmed:15316008|pubmed:22974441	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:808091	annotation-score:1.00|method-score:0.53|interaction-score:0.727
uniprotkb:P35568	uniprotkb:Q06124	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PTN11_HUMAN(gene name)	-	-	psi-mi:MI:0686(unspecified method)|psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0415(enzymatic study)|psi-mi:MI:0107(surface plasmon resonance)	-	pubmed:22974441|pubmed:11781100|pubmed:9535915|pubmed:8505282|pubmed:9756938|pubmed:7513703	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0471(mint)	mint:8037305	annotation-score:0.60|method-score:0.88|interaction-score:0.725
uniprotkb:P35568	uniprotkb:Q04917	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:1433F_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:1313(proximity labelling technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:30240640|pubmed:11969417|pubmed:33961781|pubmed:36931259|pubmed:28514442	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-54457021	annotation-score:0.60|method-score:0.85|interaction-score:0.714
uniprotkb:P35568	uniprotkb:Q05397	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:FAK1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0018(two hybrid)	-	pubmed:9822703	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:8570	annotation-score:1.00|method-score:0.51|interaction-score:0.713
uniprotkb:P35568	uniprotkb:Q6ZMU5	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:TRI72_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0090(protein complementation assay)|psi-mi:MI:0096(pull down)	-	pubmed:27810898|pubmed:29884820|pubmed:32055715|pubmed:36337049	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:3559308	annotation-score:0.60|method-score:0.84|interaction-score:0.708
uniprotkb:P35568	uniprotkb:P42345	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:MTOR_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0415(enzymatic study)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:30240640|pubmed:11287630|pubmed:16354680|pubmed:15952059	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0974(innatedb)	innatedb:120152	annotation-score:0.60|method-score:0.82|interaction-score:0.702
uniprotkb:P35568	uniprotkb:Q92569	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:P55G_HUMAN(gene name)	-	-	psi-mi:MI:0018(two hybrid)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0729(luminescence based mammalian interactome mapping)|psi-mi:MI:0397(two hybrid array)|psi-mi:MI:1356(validated two hybrid)	-	pubmed:25814554|pubmed:10417350|pubmed:9415396|pubmed:unassigned1126	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-10702435	annotation-score:0.60|method-score:0.81|interaction-score:0.696
uniprotkb:P35568	uniprotkb:P61981	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:1433G_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:1313(proximity labelling technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:30240640|pubmed:33961781|pubmed:36931259|pubmed:28514442	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-54455945	annotation-score:0.60|method-score:0.80|interaction-score:0.694
uniprotkb:P35568	uniprotkb:P62258	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:1433E_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0018(two hybrid)|psi-mi:MI:0030(cross-linking study)|psi-mi:MI:0405(competition binding)	-	pubmed:9111084|pubmed:30240640|pubmed:36931259|pubmed:9312143	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0471(mint)	mint:8005175	annotation-score:0.60|method-score:0.80|interaction-score:0.692
uniprotkb:P35568	uniprotkb:P31946	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:1433B_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0096(pull down)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:30240640|pubmed:9422753|pubmed:33961781|pubmed:28514442	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-54455467	annotation-score:0.60|method-score:0.78|interaction-score:0.686
uniprotkb:P35568	uniprotkb:Q8N3Y1	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:FBXW8_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0096(pull down)|psi-mi:MI:0415(enzymatic study)	-	pubmed:18498745|pubmed:33854235|pubmed:23045529	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:724499	annotation-score:0.60|method-score:0.76|interaction-score:0.674
uniprotkb:P35568	uniprotkb:Q07666	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:KHDR1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0055(fluorescent resonance energy transfer)	-	pubmed:11604231|pubmed:22005517|pubmed:8175658	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:861069	annotation-score:0.60|method-score:0.74|interaction-score:0.664
uniprotkb:P35568	uniprotkb:O43639	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:NCK2_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)	-	pubmed:9843575	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:317487	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:P00533	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:EGFR_HUMAN(gene name)	-	-	psi-mi:MI:0686(unspecified method)|psi-mi:MI:0089(protein array)	-	pubmed:16273093	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0471(mint)	mint:74551	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:P04626	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:ERBB2_HUMAN(gene name)	-	-	psi-mi:MI:0686(unspecified method)|psi-mi:MI:0089(protein array)	-	pubmed:16273093	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0471(mint)	mint:74553	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:P27361	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:MK03_HUMAN(gene name)	-	-	psi-mi:MI:0415(enzymatic study)	-	pubmed:17640984	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:2381460	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:P35568	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:IRS1_HUMAN(gene name)	-	-	psi-mi:MI:0415(enzymatic study)	-	pubmed:8995282	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:2562854	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:Q08345	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:DDR1_HUMAN(gene name)	-	-	psi-mi:MI:0424(protein kinase assay)	-	pubmed:17721511	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0217(phosphorylation reaction)	psi-mi:MI:0469(intact)	intact:EBI-1381086	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:Q5S007	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:LRRK2_HUMAN(gene name)	-	-	psi-mi:MI:0089(protein array)	-	pubmed:24947832	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0469(intact)	intact:EBI-9659864	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:Q96RG2	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PASK_HUMAN(gene name)	-	-	psi-mi:MI:0415(enzymatic study)	-	pubmed:9761740	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:2544718	annotation-score:1.00|method-score:0.42|interaction-score:0.647
uniprotkb:P35568	uniprotkb:O43739	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CYH3_HUMAN(gene name)	-	-	psi-mi:MI:0006(anti bait coimmunoprecipitation)	-	pubmed:17167487	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-15616127	annotation-score:1.00|method-score:0.42|interaction-score:0.646
uniprotkb:P35568	uniprotkb:Q99418	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CYH2_HUMAN(gene name)	-	-	psi-mi:MI:0006(anti bait coimmunoprecipitation)	-	pubmed:17167487	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-15616127	annotation-score:1.00|method-score:0.42|interaction-score:0.646
uniprotkb:P35568	uniprotkb:O15524	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:SOCS1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:12228220|pubmed:29991678|pubmed:17276034	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:685224	annotation-score:0.60|method-score:0.68|interaction-score:0.640
uniprotkb:P35568	uniprotkb:O75815	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:BCAR3_HUMAN(gene name)	-	-	psi-mi:MI:0018(two hybrid)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0397(two hybrid array)|psi-mi:MI:0729(luminescence based mammalian interactome mapping)|psi-mi:MI:1356(validated two hybrid)	-	pubmed:25814554|pubmed:unassigned1126	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-10704481	annotation-score:0.60|method-score:0.67|interaction-score:0.634
uniprotkb:P35568	uniprotkb:P18031	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PTN1_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0434(phosphatase assay)	-	pubmed:10660596|pubmed:11579209	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0203(dephosphorylation reaction)	psi-mi:MI:0471(mint)	mint:6793745	annotation-score:0.60|method-score:0.66|interaction-score:0.629
uniprotkb:P35568	uniprotkb:O76071	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CIAO1_HUMAN(gene name)	-	-	psi-mi:MI:1313(proximity labelling technology)	-	pubmed:37689310	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:3568149	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:P06241	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:FYN_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29269414	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2534298	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:P19784	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CSK22_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2524412	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:P48729	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:KC1A_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2524411	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:P49841	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:GSK3B_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29526746	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2529644	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:Q13627	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:DYR1A_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30773093	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2633286	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:Q676U5	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:A16L1_HUMAN(gene name)	-	-	psi-mi:MI:1313(proximity labelling technology)	-	pubmed:37689310	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:3567976	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:Q9UKB1	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:FBW1B_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2524414	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:Q9UM73	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:ALK_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:14968112	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:428379	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:Q9Y297	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:FBW1A_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2524416	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:Q9Y2I1	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:NISCH_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:11912194	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:299158	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:Q9Y5K6	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CD2AP_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29729186	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2569978	annotation-score:1.00|method-score:0.38|interaction-score:0.618
uniprotkb:P35568	uniprotkb:P31947	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:1433S_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0030(cross-linking study)|psi-mi:MI:0676(tandem affinity purification)	-	pubmed:15778465|pubmed:36931259	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0471(mint)	mint:3975430	annotation-score:0.60|method-score:0.60|interaction-score:0.601
uniprotkb:P35568	uniprotkb:Q96EB6	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:SIR1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0006(anti bait coimmunoprecipitation)	-	pubmed:17901049|pubmed:21241768	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-5273449	annotation-score:0.60|method-score:0.60|interaction-score:0.601
uniprotkb:P35568	uniprotkb:P49757	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:NUMB_HUMAN(gene name)	-	-	psi-mi:MI:0018(two hybrid)|psi-mi:MI:0397(two hybrid array)|psi-mi:MI:1356(validated two hybrid)	-	pubmed:25814554|pubmed:unassigned1126	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-10703909	annotation-score:0.60|method-score:0.59|interaction-score:0.594
uniprotkb:P35568	uniprotkb:O00459	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:P85B_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640|pubmed:23604317	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:859013	annotation-score:0.60|method-score:0.57|interaction-score:0.584
uniprotkb:P35568	uniprotkb:P17480	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:UBF1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:12554758|pubmed:17332342	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:533755	annotation-score:0.60|method-score:0.57|interaction-score:0.584
uniprotkb:P35568	uniprotkb:P22681	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CBL_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29729186|pubmed:10854852	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:645285	annotation-score:0.60|method-score:0.57|interaction-score:0.584
uniprotkb:P35568	uniprotkb:P27348	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:1433T_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:1313(proximity labelling technology)	-	pubmed:30240640|pubmed:36931259	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:3535667	annotation-score:0.60|method-score:0.57|interaction-score:0.584
uniprotkb:P35568	uniprotkb:P42338	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PK3CB_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29526746|pubmed:23604317	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:859015	annotation-score:0.60|method-score:0.57|interaction-score:0.584
uniprotkb:P35568	uniprotkb:Q13191	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CBLB_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29729186|pubmed:16734387	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:438500	annotation-score:0.60|method-score:0.57|interaction-score:0.584
uniprotkb:P35568	uniprotkb:Q14999	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CUL7_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:18498745|pubmed:29269414	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2534301	annotation-score:0.60|method-score:0.57|interaction-score:0.584
uniprotkb:P35568	uniprotkb:Q96FA3	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PELI1_HUMAN(gene name)	-	-	psi-mi:MI:0018(two hybrid)|psi-mi:MI:0397(two hybrid array)	-	pubmed:25814554|pubmed:unassigned1126	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-10698725	annotation-score:0.60|method-score:0.55|interaction-score:0.576
uniprotkb:P35568	uniprotkb:Q92769	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:HDAC2_HUMAN(gene name)	-	-	psi-mi:MI:0018(two hybrid)|psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:15522123	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:471168	annotation-score:0.60|method-score:0.55|interaction-score:0.573
uniprotkb:P35568	uniprotkb:Q06609	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:RAD51_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0096(pull down)	-	pubmed:14559999	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:2614309	annotation-score:0.60|method-score:0.52|interaction-score:0.561
uniprotkb:P35568	uniprotkb:Q9BUZ4	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:TRAF4_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0415(enzymatic study)	-	pubmed:33991522	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:3196711	annotation-score:0.60|method-score:0.52|interaction-score:0.561
uniprotkb:P35568	uniprotkb:Q9HAT8	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PELI2_HUMAN(gene name)	-	-	psi-mi:MI:0018(two hybrid)|psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:34674267	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:3382847	annotation-score:0.60|method-score:0.51|interaction-score:0.552
uniprotkb:P35568	uniprotkb:P23468	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PTPRD_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)|psi-mi:MI:0089(protein array)	-	pubmed:22305495	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0471(mint)	mint:8144217	annotation-score:0.60|method-score:0.48|interaction-score:0.536
uniprotkb:P35568	uniprotkb:Q9H6Z9	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:EGLN3_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:26972000	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0469(intact)	intact:EBI-12503146	annotation-score:0.60|method-score:0.48|interaction-score:0.536
uniprotkb:P35568	uniprotkb:P16885	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PLCG2_HUMAN(gene name)	-	-	psi-mi:MI:0686(unspecified method)	-	pubmed:22974441	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:808090	annotation-score:1.00|method-score:0.28|interaction-score:0.527
uniprotkb:P35568	uniprotkb:P84022	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:SMAD3_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0676(tandem affinity purification)	-	pubmed:18729074	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0469(intact)	intact:EBI-2696171	annotation-score:0.60|method-score:0.44|interaction-score:0.515
uniprotkb:P35568	uniprotkb:Q9P2J3	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:KLHL9_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:1313(proximity labelling technology)	-	pubmed:31515271	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2766439	annotation-score:0.60|method-score:0.44|interaction-score:0.515
uniprotkb:P35568	uniprotkb:Q9P2N7	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:KLH13_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:1313(proximity labelling technology)	-	pubmed:31515271	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2766442	annotation-score:0.60|method-score:0.44|interaction-score:0.515
uniprotkb:P35568	uniprotkb:P05067	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:A4_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)	-	pubmed:21832049	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:737677	annotation-score:0.60|method-score:0.42|interaction-score:0.501
uniprotkb:P35568	uniprotkb:P0CG48	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:UBC_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)	-	pubmed:23045529	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:724500	annotation-score:0.60|method-score:0.42|interaction-score:0.501
uniprotkb:P35568	uniprotkb:P24394	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:IL4RA_HUMAN(gene name)	-	-	psi-mi:MI:0077(nuclear magnetic resonance)	-	pubmed:8599766	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0469(intact)	intact:EBI-22275536	annotation-score:0.60|method-score:0.42|interaction-score:0.501
uniprotkb:P35568	uniprotkb:P46934	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:NEDD4_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)	-	pubmed:19953087	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:611360	annotation-score:0.60|method-score:0.42|interaction-score:0.501
uniprotkb:P35568	uniprotkb:Q92572	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:AP3S1_HUMAN(gene name)	-	-	psi-mi:MI:0096(pull down)	-	pubmed:9792713	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:282803	annotation-score:0.60|method-score:0.42|interaction-score:0.501
uniprotkb:P35568	uniprotkb:Q92729	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PTPRU_HUMAN(gene name)	-	-	psi-mi:MI:0415(enzymatic study)	-	pubmed:11781100	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:824664	annotation-score:0.60|method-score:0.42|interaction-score:0.501
uniprotkb:P35568	uniprotkb:P11940	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PABP1_HUMAN(gene name)	-	-	psi-mi:MI:0006(anti bait coimmunoprecipitation)	-	pubmed:23770097	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association)	psi-mi:MI:0471(mint)	mint:8432446	annotation-score:0.60|method-score:0.42|interaction-score:0.500
uniprotkb:P35568	uniprotkb:Q8TCJ0	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:FBX25_HUMAN(gene name)	-	-	psi-mi:MI:0415(enzymatic study)	-	pubmed:23940030	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0407(direct interaction)	psi-mi:MI:0463(biogrid)	biogrid:886310	annotation-score:0.55|method-score:0.42|interaction-score:0.480
uniprotkb:P35568	uniprotkb:O14512	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:SOCS7_HUMAN(gene name)	-	-	psi-mi:MI:0007(anti tag coimmunoprecipitation)	-	pubmed:16127460	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0974(innatedb)	innatedb:117605	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:O14543	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:SOCS3_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:15514089	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:720071	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:O14641	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:DVL2_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:24616100	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:933005	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:P03372	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:ESR1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:12821935	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:504125	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:P10415	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:BCL2_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:10679027	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:282195	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:P10586	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:PTPRF_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:8995282	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2562856	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:P63104	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:1433Z_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2524404	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:P67870	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CSK2B_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2524413	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:P78317	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:RNF4_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29180619	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2493686	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:Q07817	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:B2CL1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:10679027	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:282196	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:Q13616	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CUL1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30240640	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2524395	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:Q13618	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CUL3_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:31515271	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2766436	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:Q5XPI4	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:RN123_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29676528	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2525302	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:Q92731	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:ESR2_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29509190	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2520376	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:Q93008	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:USP9X_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30338032	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2596668	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:Q9UGI0	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:ZRAN1_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:35944360	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:3470883	annotation-score:0.60|method-score:0.38|interaction-score:0.479
uniprotkb:P35568	uniprotkb:P16671	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:CD36_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:29269414	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2534299	annotation-score:0.55|method-score:0.38|interaction-score:0.458
uniprotkb:P35568	uniprotkb:P06730	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:IF4E_HUMAN(gene name)	-	-	psi-mi:MI:0006(anti bait coimmunoprecipitation)	-	pubmed:23770097	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0914(association)	psi-mi:MI:0471(mint)	mint:8432446	annotation-score:0.60|method-score:0.33|interaction-score:0.445
uniprotkb:P35568	uniprotkb:Q8IYP9	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:ZDH23_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30658672	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2619224	annotation-score:0.50|method-score:0.38|interaction-score:0.437
uniprotkb:P35568	uniprotkb:Q9NUE0	uniprotkb:IRS1_HUMAN(gene name)	uniprotkb:ZDH18_HUMAN(gene name)	-	-	psi-mi:MI:0004(affinity chromatography technology)	-	pubmed:30658672	taxid:9606(Homo sapiens)	taxid:9606(Homo sapiens)	psi-mi:MI:0915(physical association)	psi-mi:MI:0463(biogrid)	biogrid:2619193	annotation-score:0.50|method-score:0.38|interaction-score:0.437
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