*************Generated from HitPredict database (15Jul2024)************* List of interactions for P36594|RPB1|Schizosaccharomyces pombe 972h-|Interactions:39 ************************************************************************ Interactor A ID Interactor B ID Interactor A Name Interactor B Name Interactor A Alias Interactor B Alias Interaction detection methods First author Publications Interactor A Taxonomy Interactor B Taxonomy Interaction type Source database Interaction identifier Confidence score uniprotkb:P36594 uniprotkb:P37382 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPB3_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting)|psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0401(biochemical)|psi-mi:MI:0006(anti bait coimmunoprecipitation)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:9642054|pubmed:10648788|pubmed:9325316|pubmed:15743411|pubmed:11839823|pubmed:11168400|pubmed:14534314|pubmed:15620689 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0471(mint) mint:50452 annotation-score:1.00|method-score:0.92|interaction-score:0.960 uniprotkb:P36594 uniprotkb:Q09191 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPAB1_SCHPO(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0096(pull down)|psi-mi:MI:0047(far western blotting)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0006(anti bait coimmunoprecipitation) - pubmed:9738888|pubmed:9077438|pubmed:9642054|pubmed:10648788|pubmed:9325316|pubmed:15743411|pubmed:14534314 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-1534096 annotation-score:1.00|method-score:0.91|interaction-score:0.954 uniprotkb:P36594 uniprotkb:O14459 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPB7_SCHPO(gene name) - - psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0047(far western blotting)|psi-mi:MI:0006(anti bait coimmunoprecipitation) - pubmed:10648788|pubmed:9325316|pubmed:15743411|pubmed:9642054|pubmed:16204182|pubmed:14534314 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-1534096 annotation-score:1.00|method-score:0.87|interaction-score:0.933 uniprotkb:P36594 uniprotkb:P87123 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPB11_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting)|psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0006(anti bait coimmunoprecipitation) - pubmed:9642054|pubmed:10648788|pubmed:9325316|pubmed:15743411|pubmed:14534314 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-1534096 annotation-score:1.00|method-score:0.83|interaction-score:0.909 uniprotkb:P36594 uniprotkb:Q02061 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPB2_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting)|psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0006(anti bait coimmunoprecipitation) - pubmed:9642054|pubmed:10648788|pubmed:9325316|pubmed:15743411|pubmed:14534314 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-1534096 annotation-score:1.00|method-score:0.83|interaction-score:0.909 uniprotkb:P36594 uniprotkb:Q92399 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPAB3_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting)|psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology) - pubmed:9642054|pubmed:10648788|pubmed:9325316|pubmed:15743411 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:250152 annotation-score:1.00|method-score:0.78|interaction-score:0.882 uniprotkb:P36594 uniprotkb:P36595 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPAB2_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0401(biochemical) - pubmed:9642054|pubmed:9325316|pubmed:15743411|pubmed:9322754 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0463(biogrid) biogrid:250797 annotation-score:1.00|method-score:0.76|interaction-score:0.873 uniprotkb:P36594 uniprotkb:O60104 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:MED7_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0401(biochemical) - pubmed:28515143|pubmed:12738880|pubmed:15182371|pubmed:10625684 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0463(biogrid) biogrid:250809 annotation-score:1.00|method-score:0.75|interaction-score:0.867 uniprotkb:P36594 uniprotkb:P48011 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPAB4_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting)|psi-mi:MI:0004(affinity chromatography technology) - pubmed:9642054|pubmed:9325316|pubmed:15743411 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:250156 annotation-score:1.00|method-score:0.70|interaction-score:0.834 uniprotkb:P36594 uniprotkb:O74825 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPB4_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0006(anti bait coimmunoprecipitation) - pubmed:15743411|pubmed:14534314 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-1534096 annotation-score:1.00|method-score:0.54|interaction-score:0.737 uniprotkb:P36594 uniprotkb:O13877 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPAB5_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting)|psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0006(anti bait coimmunoprecipitation) - pubmed:9642054|pubmed:9325316|pubmed:15743411|pubmed:14534314 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-1534096 annotation-score:0.60|method-score:0.76|interaction-score:0.676 uniprotkb:P36594 uniprotkb:Q9UTE3 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:SEB1_SCHPO(gene name) - - psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology) - pubmed:28367989|pubmed:27401558|pubmed:30282034 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3377419 annotation-score:0.60|method-score:0.74|interaction-score:0.667 uniprotkb:P36594 uniprotkb:O14026 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:SET2_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0047(far western blotting) - pubmed:24583182|pubmed:26792892|pubmed:15798214 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:250012 annotation-score:0.60|method-score:0.74|interaction-score:0.664 uniprotkb:P36594 uniprotkb:P40997 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:MCE1_SCHPO(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0114(x-ray crystallography)|psi-mi:MI:0096(pull down) - pubmed:11893740|pubmed:11387325|pubmed:24939935 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0914(association) psi-mi:MI:0463(biogrid) biogrid:3656271 annotation-score:0.60|method-score:0.73|interaction-score:0.661 uniprotkb:P36594 uniprotkb:Q96WV9 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CDK9_SCHPO(gene name) - - psi-mi:MI:0415(enzymatic study)|psi-mi:MI:0096(pull down) - pubmed:25691663|pubmed:20605454|pubmed:22508988 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:664617 annotation-score:0.60|method-score:0.71|interaction-score:0.655 uniprotkb:P36594 uniprotkb:O74635 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RPB9_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:15743411 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:250153 annotation-score:1.00|method-score:0.38|interaction-score:0.618 uniprotkb:P36594 uniprotkb:Q12126 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CRK1_SCHPO(gene name) - - psi-mi:MI:0415(enzymatic study) - pubmed:25691663|pubmed:20605454 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:448495 annotation-score:0.60|method-score:0.60|interaction-score:0.602 uniprotkb:P36594 uniprotkb:Q9P6Q6 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CET1_SCHPO(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:11893740|pubmed:11387325 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:249067 annotation-score:0.60|method-score:0.57|interaction-score:0.584 uniprotkb:P36594 uniprotkb:O14098 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CTK1_SCHPO(gene name) - - psi-mi:MI:0415(enzymatic study) - pubmed:20605454 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:448497 annotation-score:0.60|method-score:0.42|interaction-score:0.501 uniprotkb:P36594 uniprotkb:O74627 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CG1C_SCHPO(gene name) - - psi-mi:MI:0096(pull down) - pubmed:22508988 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:664618 annotation-score:0.60|method-score:0.42|interaction-score:0.501 uniprotkb:P36594 uniprotkb:P79011 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:T2EB_SCHPO(gene name) - - psi-mi:MI:0047(far western blotting) - pubmed:15743411 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:261432 annotation-score:0.60|method-score:0.42|interaction-score:0.501 uniprotkb:P36594 uniprotkb:O14327 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:PAB2_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:19336419 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:882494 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:O42861 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:FFT3_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:28218250 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2597576 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:O74448 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:PIN1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:33410907 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3377162 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:O74954 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CBF11_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:22540037 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:664870 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:O74957 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:AGO1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:29237752 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2574737 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:O94603 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:JHD1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:24013502 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1026188 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:P13681 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:PP11_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:24945319 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1023516 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:Q09704 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:RRP4_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:30321377 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2592348 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:Q09892 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:HOG1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:33410907 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3377161 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:Q10103 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CHP1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:29237752 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2574738 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:Q9HGP4 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:YK82_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:24013502 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1025995 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:Q9P376 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:FCP1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:11839823 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:248960 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:Q9Y7R4 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:SET1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:26098123 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2594223 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:Q9Y812 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:CENPA_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:30503616 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2611565 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:P36594 uniprotkb:O14140 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:SEM1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:30355493 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2529983 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:P36594 uniprotkb:Q9P7X2 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:ELL1_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:17150956 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:250673 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:P36594 uniprotkb:Q9UTR1 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:MMS19_SCHPO(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:21725325 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:592875 annotation-score:0.55|method-score:0.38|interaction-score:0.458 uniprotkb:P36594 uniprotkb:Q10477 uniprotkb:RPB1_SCHPO(gene name) uniprotkb:MED27_SCHPO(gene name) - - psi-mi:MI:0401(biochemical) - pubmed:11572939 taxid:284812(Schizosaccharomyces pombe 972h-) taxid:284812(Schizosaccharomyces pombe 972h-) psi-mi:MI:0914(association) psi-mi:MI:0463(biogrid) biogrid:250780 annotation-score:0.55|method-score:0.33|interaction-score:0.426 *************Service provided by Combinatics****************************