*************Generated from HitPredict database (15Jul2024)************* List of interactions for Q9Y620|RA54B|Homo sapiens|Interactions:45 ************************************************************************ Interactor A ID Interactor B ID Interactor A Name Interactor B Name Interactor A Alias Interactor B Alias Interaction detection methods First author Publications Interactor A Taxonomy Interactor B Taxonomy Interaction type Source database Interaction identifier Confidence score uniprotkb:Q9Y620 uniprotkb:Q9Y620 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:RA54B_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:25416956|pubmed:16189514|pubmed:19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-759217 annotation-score:1.00|method-score:0.72|interaction-score:0.847 uniprotkb:Q9Y620 uniprotkb:Q06609 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:RAD51_HUMAN(gene name) - - psi-mi:MI:0096(pull down)|psi-mi:MI:0004(affinity chromatography technology) - pubmed:18718930|pubmed:10851248|pubmed:16428451 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:860149 annotation-score:0.60|method-score:0.74|interaction-score:0.667 uniprotkb:Q9Y620 uniprotkb:Q14191 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:WRN_HUMAN(gene name) - - psi-mi:MI:0047(far western blotting) - pubmed:17118963 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:554938 annotation-score:1.00|method-score:0.42|interaction-score:0.647 uniprotkb:Q9Y620 uniprotkb:P68431 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:H31_HUMAN(gene name) - - psi-mi:MI:1313(proximity labelling technology) - pubmed:36089195 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3517703 annotation-score:1.00|method-score:0.38|interaction-score:0.618 uniprotkb:Q9Y620 uniprotkb:Q8TBB1 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:LNX1_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:1356(validated two hybrid)|psi-mi:MI:0397(two hybrid array)|psi-mi:MI:1112(two hybrid prey pooling approach)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514|pubmed:32296183|pubmed:unassigned1304 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-759655 annotation-score:0.50|method-score:0.74|interaction-score:0.609 uniprotkb:Q9Y620 uniprotkb:P25786 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:PSA1_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514|pubmed:19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-755941 annotation-score:0.55|method-score:0.63|interaction-score:0.587 uniprotkb:Q9Y620 uniprotkb:P63165 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:SUMO1_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:25416956|pubmed:21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:1438728 annotation-score:0.60|method-score:0.57|interaction-score:0.584 uniprotkb:Q9Y620 uniprotkb:Q8N8B7 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:TEANC_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:25416956|pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:121352 annotation-score:0.60|method-score:0.57|interaction-score:0.584 uniprotkb:Q9Y620 uniprotkb:Q9H4K1 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:RIBC2_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0397(two hybrid array)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514|pubmed:31515488 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-758257 annotation-score:0.55|method-score:0.62|interaction-score:0.582 uniprotkb:Q9Y620 uniprotkb:O15151 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:MDM4_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0096(pull down) - pubmed:25384516 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:1054661 annotation-score:0.60|method-score:0.52|interaction-score:0.561 uniprotkb:Q9Y620 uniprotkb:Q9UJX2 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:CDC23_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:25416956|pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-755449 annotation-score:0.50|method-score:0.63|interaction-score:0.559 uniprotkb:Q9Y620 uniprotkb:Q9HCH3 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:CPNE5_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:28514442|pubmed:33961781 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-21757216 annotation-score:0.50|method-score:0.62|interaction-score:0.558 uniprotkb:Q9Y620 uniprotkb:P49674 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:KC1E_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-757558 annotation-score:0.60|method-score:0.49|interaction-score:0.541 uniprotkb:Q9Y620 uniprotkb:P63279 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:UBC9_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-757909 annotation-score:0.60|method-score:0.49|interaction-score:0.541 uniprotkb:Q9Y620 uniprotkb:Q92630 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:DYRK2_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-757351 annotation-score:0.60|method-score:0.49|interaction-score:0.541 uniprotkb:Q9Y620 uniprotkb:Q9UK33 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:ZN580_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-755269 annotation-score:0.60|method-score:0.49|interaction-score:0.541 uniprotkb:Q9Y620 uniprotkb:P17936 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:IBP3_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0397(two hybrid array) - pubmed:24412244 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0471(mint) mint:8434941 annotation-score:0.55|method-score:0.49|interaction-score:0.518 uniprotkb:Q9Y620 uniprotkb:Q96HF1 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:SFRP2_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0397(two hybrid array) - pubmed:24412244 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0471(mint) mint:8434941 annotation-score:0.55|method-score:0.49|interaction-score:0.518 uniprotkb:Q9Y620 uniprotkb:P54253 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:ATX1_HUMAN(gene name) - - psi-mi:MI:0397(two hybrid array)|psi-mi:MI:0398(two hybrid pooling approach)|psi-mi:MI:1356(validated two hybrid) - pubmed:32814053 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-26291438 annotation-score:0.60|method-score:0.44|interaction-score:0.515 uniprotkb:Q9Y620 uniprotkb:Q9H063 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:MAF1_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology)|psi-mi:MI:0007(anti tag coimmunoprecipitation) - pubmed:28514442 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association)|psi-mi:MI:0914(association) psi-mi:MI:0469(intact) intact:EBI-21704986 annotation-score:0.55|method-score:0.48|interaction-score:0.513 uniprotkb:Q9Y620 uniprotkb:P16885 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:PLCG2_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0004(affinity chromatography technology) - pubmed:25814554 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1416578 annotation-score:0.50|method-score:0.51|interaction-score:0.504 uniprotkb:Q9Y620 uniprotkb:Q9NP31 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:SH22A_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0004(affinity chromatography technology) - pubmed:25814554 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1416579 annotation-score:0.50|method-score:0.51|interaction-score:0.504 uniprotkb:Q9Y620 uniprotkb:Q14565 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:DMC1_HUMAN(gene name) - - psi-mi:MI:0096(pull down) - pubmed:18718930 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:2595931 annotation-score:0.60|method-score:0.42|interaction-score:0.501 uniprotkb:Q9Y620 uniprotkb:Q9H8Y8 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:GORS2_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-755800 annotation-score:0.50|method-score:0.49|interaction-score:0.494 uniprotkb:Q9Y620 uniprotkb:Q13131 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:AAPK1_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:25416956 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:1041048 annotation-score:0.60|method-score:0.39|interaction-score:0.481 uniprotkb:Q9Y620 uniprotkb:Q96IK5 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:GMCL1_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:25416956 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:1046716 annotation-score:0.60|method-score:0.39|interaction-score:0.481 uniprotkb:Q9Y620 uniprotkb:O95400 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:CD2B2_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:242458 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:Q9Y620 uniprotkb:P35637 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:FUS_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:25192599 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1031697 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:Q9Y620 uniprotkb:Q00987 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:MDM2_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:25384516 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:1054659 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:Q9Y620 uniprotkb:Q13618 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:CUL3_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:35563538 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3408286 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:Q9Y620 uniprotkb:Q7L5N1 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:CSN6_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:690049 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:Q9Y620 uniprotkb:Q7Z3E1 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:PARPT_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:35439318 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3503962 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:Q9Y620 uniprotkb:Q9H6Z9 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:EGLN3_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:26972000 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:2465835 annotation-score:0.60|method-score:0.38|interaction-score:0.479 uniprotkb:Q9Y620 uniprotkb:Q9GZT8 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:NIF3L_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:838836 annotation-score:0.55|method-score:0.39|interaction-score:0.460 uniprotkb:Q9Y620 uniprotkb:Q14241 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:ELOA1_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:838886 annotation-score:0.50|method-score:0.39|interaction-score:0.439 uniprotkb:Q9Y620 uniprotkb:Q13451 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:FKBP5_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:35271311 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:3356134 annotation-score:0.50|method-score:0.38|interaction-score:0.437 uniprotkb:Q9Y620 uniprotkb:Q9P2P5 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:HECW2_HUMAN(gene name) - - psi-mi:MI:0004(affinity chromatography technology) - pubmed:24163370 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0915(physical association) psi-mi:MI:0463(biogrid) biogrid:914806 annotation-score:0.50|method-score:0.38|interaction-score:0.437 uniprotkb:Q9Y620 uniprotkb:Q8N5M1 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:ATPF2_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:25416956|pubmed:25910212 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:2207242 annotation-score:0.16|method-score:0.57|interaction-score:0.304 uniprotkb:Q9Y620 uniprotkb:O75865 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:TPC6A_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-758779 annotation-score:0.16|method-score:0.49|interaction-score:0.282 uniprotkb:Q9Y620 uniprotkb:Q14032 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:BAAT_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0397(two hybrid array) - pubmed:24412244 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0471(mint) mint:8434941 annotation-score:0.16|method-score:0.49|interaction-score:0.282 uniprotkb:Q9Y620 uniprotkb:Q8N5R6 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:CCD33_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0398(two hybrid pooling approach) - pubmed:16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0469(intact) intact:EBI-752749 annotation-score:0.16|method-score:0.49|interaction-score:0.282 uniprotkb:Q9Y620 uniprotkb:Q9BU70 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:TRMO_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid)|psi-mi:MI:0397(two hybrid array) - pubmed:24412244 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction)|psi-mi:MI:0915(physical association) psi-mi:MI:0471(mint) mint:8434941 annotation-score:0.16|method-score:0.49|interaction-score:0.282 uniprotkb:Q9Y620 uniprotkb:Q6ZVK8 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:NUD18_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:838880 annotation-score:0.16|method-score:0.39|interaction-score:0.251 uniprotkb:Q9Y620 uniprotkb:Q9H0I2 uniprotkb:RA54B_HUMAN(gene name) uniprotkb:ENKD1_HUMAN(gene name) - - psi-mi:MI:0018(two hybrid) - pubmed:25416956 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) psi-mi:MI:0407(direct interaction) psi-mi:MI:0463(biogrid) biogrid:1046718 annotation-score:0.16|method-score:0.39|interaction-score:0.251 *************Service provided by Combinatics****************************