Protein: ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)

Gene: ERF3A, GSPT1
Organism: Homo sapiens
Interactions: 229
UniProt ID: P15170

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0003747 - translation release factor activity
GO:0003924 - GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

545815

ERF1
Eukaryotic peptide chain release factor subunit 1

8

8

Small-scale

0.968

High

545882

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

4

11

High-throughput

0.903

High

545857

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

6

High-throughput

0.789

High

516347

PABP1
Polyadenylate-binding protein 1

5

8

Small-scale

0.720

High

545891

RENT1
Regulator of nonsense transcripts 1

5

7

Small-scale

0.716

High

545895

CRBN
Protein cereblon

1

0

Small-scale

0.708

High

398632

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

3

High-throughput

0.691

High

400734

RLA0
Large ribosomal subunit protein uL10

1

4

High-throughput

0.691

High

545755

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

1

High-throughput

0.691

High

545765

RL9
Large ribosomal subunit protein uL6

1

1

High-throughput

0.691

High

545774

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

8

High-throughput

0.691

High

545901

GNL3
Guanine nucleotide-binding protein-like 3

1

3

High-throughput

0.691

High

545920

DRG1
Developmentally-regulated GTP-binding protein 1

1

3

High-throughput

0.691

High

545809

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.656

High

322138

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

9

High-throughput

0.656

High

226427

PRKN
E3 ubiquitin-protein ligase parkin

3

13

High-throughput

0.640

High

545802

PFD3
Prefoldin subunit 3

2

1

High-throughput

0.628

High

545787

ATX1
Ataxin-1

2

3

High-throughput

0.625

High

545837

XIAP
E3 ubiquitin-protein ligase XIAP

2

6

Small-scale

0.624

High

545907

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.618

High

386028

P53
Cellular tumor antigen p53

2

3

High-throughput

0.611

High

545797

ABCE1
ATP-binding cassette sub-family E member 1

2

3

High-throughput

0.611

High

345834

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.584

High

436893

ACM4
Muscarinic acetylcholine receptor M4

2

3

High-throughput

0.574

High

545912

RHG23
Rho GTPase-activating protein 23

2

3

High-throughput

0.571

High

545849

BIRC2
Baculoviral IAP repeat-containing protein 2

1

7

Small-scale

0.561

High

545762

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.541

High

78270

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

1

High-throughput

0.536

High

124751

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

7

High-throughput

0.536

High

128013

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

11

High-throughput

0.536

High

161954

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

13

High-throughput

0.536

High

165389

SR140
U2 snRNP-associated SURP motif-containing protein

1

10

High-throughput

0.536

High

172818

CASC3
Protein CASC3

1

2

High-throughput

0.536

High

176111

PPM1G
Protein phosphatase 1G

1

2

High-throughput

0.536

High

176936

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

11

High-throughput

0.536

High

202044

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

8

High-throughput

0.536

High

203336

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

4

High-throughput

0.536

High

235692

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

8

High-throughput

0.536

High

275790

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

12

High-throughput

0.536

High

283377

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

335042

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

2

High-throughput

0.536

High

400223

RLA1
Large ribosomal subunit protein P1

1

2

High-throughput

0.536

High

416928

IF4E
Eukaryotic translation initiation factor 4E

1

2

High-throughput

0.536

High

444062

RS17
Small ribosomal subunit protein eS17

1

2

High-throughput

0.536

High

445270

RSSA
Small ribosomal subunit protein uS2

1

3

High-throughput

0.536

High

453123

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

9

High-throughput

0.536

High

496223

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

533776

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.536

High

545751

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.536

High

545753

PYRG1
CTP synthase 1

1

3

High-throughput

0.536

High

545754

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.536

High

545756

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.536

High

545758

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.536

High

545760

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

545763

T2EB
Transcription initiation factor IIE subunit beta

1

1

High-throughput

0.536

High

545768

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

545769

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

545770

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.536

High

545772

RL13A
Large ribosomal subunit protein uL13

1

4

High-throughput

0.536

High

545775

RS27
Small ribosomal subunit protein eS27

1

4

High-throughput

0.536

High

545779

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.536

High

545780

RS5
Small ribosomal subunit protein uS7

1

3

High-throughput

0.536

High

545781

PRC2A
Protein PRRC2A

1

8

High-throughput

0.536

High

545785

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.536

High

545788

GEM
GTP-binding protein GEM

1

1

High-throughput

0.536

High

545790

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

3

High-throughput

0.536

High

545793

IF4A1
Eukaryotic initiation factor 4A-I

1

4

High-throughput

0.536

High

545794

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.536

High

545795

SRP54
Signal recognition particle subunit SRP54

1

1

High-throughput

0.536

High

545803

RS7
Small ribosomal subunit protein eS7

1

2

High-throughput

0.536

High

545804

RS8
Small ribosomal subunit protein eS8

1

3

High-throughput

0.536

High

545805

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.536

High

545806

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

545808

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.536

High

545810

RS18
Small ribosomal subunit protein uS13

1

2

High-throughput

0.536

High

545811

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.536

High

545812

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.536

High

545814

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.536

High

545816

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.536

High

545817

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.536

High

545818

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.536

High

545819

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.536

High

545820

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.536

High

545827

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

545828

RL10A
Large ribosomal subunit protein uL1

1

2

High-throughput

0.536

High

545830

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.536

High

545832

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.536

High

545834

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.536

High

545838

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

High-throughput

0.536

High

545841

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

High-throughput

0.536

High

545842

DHX9
ATP-dependent RNA helicase A

1

7

High-throughput

0.536

High

545844

ILF2
Interleukin enhancer-binding factor 2

1

4

High-throughput

0.536

High

545845

ILF3
Interleukin enhancer-binding factor 3

1

12

High-throughput

0.536

High

545846

PABP4
Polyadenylate-binding protein 4

1

8

High-throughput

0.536

High

545847

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

2

High-throughput

0.536

High

545850

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

545852

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

4

High-throughput

0.536

High

545856

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

High-throughput

0.536

High

545858

ELAV1
ELAV-like protein 1

1

8

High-throughput

0.536

High

545860

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.536

High

545861

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.536

High

545865

LARP1
La-related protein 1

1

5

High-throughput

0.536

High

545870

RS27L
Ribosomal protein eS27-like

1

4

High-throughput

0.536

High

545871

MARK2
Serine/threonine-protein kinase MARK2

1

4

High-throughput

0.536

High

545873

DHX30
ATP-dependent RNA helicase DHX30

1

7

High-throughput

0.536

High

545877

DHX29
ATP-dependent RNA helicase DHX29

1

11

High-throughput

0.536

High

545879

KTN1
Kinectin

1

3

High-throughput

0.536

High

545884

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

1

High-throughput

0.536

High

545885

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

1

High-throughput

0.536

High

545893

ZFR
Zinc finger RNA-binding protein

1

4

High-throughput

0.536

High

545896

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.536

High

545898

ATX2
Ataxin-2

1

4

High-throughput

0.536

High

545899

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

9

High-throughput

0.536

High

545904

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

5

High-throughput

0.536

High

545909

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.536

High

545916

SRP68
Signal recognition particle subunit SRP68

1

2

High-throughput

0.536

High

545919

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.536

High

545921

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.536

High

545925

SRPRB
Signal recognition particle receptor subunit beta

1

6

High-throughput

0.536

High

545928

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

10

High-throughput

0.536

High

172349

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.513

High

176713

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

400445

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.513

High

521458

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.513

High

545767

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

545776

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

545778

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

545783

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.513

High

545791

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

545801

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.513

High

545821

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.513

High

545822

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.513

High

545823

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.513

High

545825

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

545829

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

545831

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.513

High

545833

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.513

High

545835

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.513

High

545836

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

545851

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.513

High

545854

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

545855

BECN1
Beclin-1

1

0

High-throughput

0.513

High

545874

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.513

High

545876

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.513

High

545878

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

545881

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

545886

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

545887

H1X
Histone H1.10

1

0

High-throughput

0.513

High

545914

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

545859

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.501

High

545923

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

Small-scale

0.501

High

545777

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.489

High

545900

HINFP
Histone H4 transcription factor

1

2

Small-scale

0.481

High

66259

WASH1
WASH complex subunit 1

1

1

High-throughput

0.479

High

149540

COPE
Coatomer subunit epsilon

1

1

High-throughput

0.479

High

162382

XPO1
Exportin-1

1

8

High-throughput

0.479

High

214071

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

275533

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

4

High-throughput

0.479

High

304016

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

Small-scale

0.479

High

337869

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

349849

RASK
GTPase KRas

1

3

High-throughput

0.479

High

545759

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.479

High

545764

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

545771

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

545773

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

545789

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

545792

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

10

High-throughput

0.479

High

545796

UBC12
NEDD8-conjugating enzyme Ubc12

1

6

High-throughput

0.479

High

545798

RS3A
Small ribosomal subunit protein eS1

1

4

High-throughput

0.479

High

545800

MGN
Protein mago nashi homolog

1

2

High-throughput

0.479

High

545807

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

545813

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

545826

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

545839

CAP1
Adenylyl cyclase-associated protein 1

1

1

High-throughput

0.479

High

545840

RL6
Large ribosomal subunit protein eL6

1

3

High-throughput

0.479

High

545848

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

545853

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

7

High-throughput

0.479

High

545868

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

545869

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

545883

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

545888

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

545889

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

545894

SMG1
Serine/threonine-protein kinase SMG1

1

1

Small-scale

0.479

High

545897

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

11

Small-scale

0.479

High

545902

RBM4
RNA-binding protein 4

1

11

High-throughput

0.479

High

545903

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.479

High

545906

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

545911

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

545915

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

545917

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

4

Small-scale

0.479

High

545918

RL26L
Ribosomal protein uL24-like

1

4

High-throughput

0.479

High

545922

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.479

High

545924

TRAF6
TNF receptor-associated factor 6

1

9

High-throughput

0.479

High

545927

RBM8A
RNA-binding protein 8A

1

10

Small-scale

0.479

High

127708

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

545757

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

545843

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

90060

D6RAT0
Small ribosomal subunit protein eS1

1

4

High-throughput

0.445

High

101622

F8VR69
Ribosomal protein L6

1

3

High-throughput

0.445

High

110710

H3BUK8
Large ribosomal subunit protein eL13

1

2

High-throughput

0.445

High

474004

PAB4L
Polyadenylate-binding protein 4-like

1

8

High-throughput

0.445

High

545799

RL26
Large ribosomal subunit protein uL24

1

4

High-throughput

0.445

High

545824

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

1

High-throughput

0.445

High

545862

R39L5
Putative ribosomal protein eL39-like 5

1

1

High-throughput

0.445

High

545910

WASH6
WAS protein family homolog 6

1

1

High-throughput

0.445

High

378981

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.437

High

384206

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

521703

CADH1
Cadherin-1

1

2

High-throughput

0.437

High

545752

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

545761

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

545766

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

545782

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

545875

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

545913

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

3

High-throughput

0.437

High

545926

MAFB
Transcription factor MafB

1

1

High-throughput

0.437

High

517033

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.417

High

545890

ESR2
Estrogen receptor beta

1

9

High-throughput

0.407

High

545784

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.373

High

545786

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.279

Low

545866

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

545880

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

545892

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

545905

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.279

Low

545908

SP30L
Histone deacetylase complex subunit SAP30L

1

0

High-throughput

0.279

Low

354275

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

545864

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

545872

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.249

Low

545863

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

Small-scale

0.232

Low

545867

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024