HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: FXR1 (Q61584)
RNA-binding protein FXR1 (FXR1P) (mFxr1p)
Gene: FXR1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0043197 - dendritic spine GO:0048170 - positive regulation of long-term neuronal synaptic plasticity and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 677
+	Hs
		843887 SHAN3_HUMAN (1-1730): 0: 601: 95.21		FXR1_HUMAN (1-677): 0: 995: 88.33
+	Hs
		844225 SHAN3_HUMAN (1-1730): 0: 601: 95.21		FXR2_HUMAN (4-656): 0: 851: 64.06
+	Mm
		1116010 SHAN3_MOUSE (1-1730): 0: 626: 100.00		Q8BPK8_MOUSE (1-334): 0: 622: 73.65
+	Hs
		843981 SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37		FXR1_HUMAN (1-677): 0: 995: 88.33
+	Mm
		1160647 CSKI1_MOUSE (55-1397): 7.52e-114: 397: 15.53		Q8BPK8_MOUSE (1-334): 0: 622: 73.65
+	Mm
		729471 SHAN3_MOUSE (1-1730): 0: 626: 100.00		FMR1_MOUSE (219-461): 1.28e-49: 184: 42.80
+	Hs
		989099 SHAN3_HUMAN (1-1730): 0: 601: 95.21		FMR1_HUMAN (300-461): 3.4e-48: 181: 56.10
+	Mm
		729514 CSKI1_MOUSE (55-1397): 7.52e-114: 397: 15.53		FMR1_MOUSE (219-461): 1.28e-49: 184: 42.80