HitPredict

Interactor 1: SNX3 (O60493)
Sorting nexin-3 (Protein SDP3)
Gene: SNX3

Interactor 2: VPS35 (Q96QK1)
Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)
Gene: VPS35

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	24344282, 35271311, 33961781, 22673115
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0010008 - endosome membrane GO:0030904 - retromer complex GO:0032456 - endocytic recycling and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 162 Hs			1 796
+	Hs
		1300514 SNX12_HUMAN (5-161): 8.43e-52: 164: 80.26		VPS35_HUMAN (1-796): 0: 1191: 100.00
+	Mm
		1322295 SNX1_MOUSE (3-162): 1.7e-43: 152: 21.34		VPS35_MOUSE (1-796): 0: 1193: 99.37
+	Hs
		1040506 SNX1_HUMAN (3-162): 2.03e-43: 151: 21.95		VPS35_HUMAN (1-796): 0: 1191: 100.00
+	Dm
		1365832 Q9VG51_DROME (4-161): 4.5e-49: 157: 70.44		Q9W277_DROME (10-786): 0: 1090: 61.49
+	Ce
		1094069 Q9GYJ9_CAEEL (24-160): 5.33e-31: 117: 16.78		Q21053_CAEEL (11-781): 0: 1008: 48.73
+	Sc
		710076 SNX3_YEAST (19-150): 3.02e-35: 122: 42.66		VPS35_YEAST (17-766): 0: 754: 31.80
+	Sc
		710083 VPS5_YEAST (29-150): 2.56e-23: 97.1: 27.64		VPS35_YEAST (17-766): 0: 754: 31.80
+	Tt
		101891 G0SH11_CHATD (10-151): 1.49e-29: 114: 29.58		G0S709_CHATD (7-314): 3.19e-149: 460: 54.69