Protein: EXOS8
Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)

Gene: EXOS8, EXOSC8
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q96B26

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001650 - fibrillar center

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1284980

EXOS5
Exosome complex component RRP46

13

19

Small-scale

0.984

High

1285000

EXOS1
Exosome complex component CSL4

9

20

High-throughput

0.974

High

1284978

EXOS4
Exosome complex component RRP41

6

19

Small-scale

0.953

High

1257149

DI3L1
DIS3-like exonuclease 1

6

19

Small-scale

0.952

High

1046319

EXOS2
Exosome complex component RRP4

6

20

Small-scale

0.945

High

986709

EXOS9
Exosome complex component RRP45

5

18

High-throughput

0.927

High

1063750

EXOS7
Exosome complex component RRP42

5

18

High-throughput

0.923

High

1284945

EXOS8
Exosome complex component RRP43

4

16

High-throughput

0.900

High

1130042

EXOS6
Exosome complex component MTR3

3

19

Small-scale

0.828

High

1284999

RRP44
Exosome complex exonuclease RRP44

2

19

Small-scale

0.806

High

1284981

EXOS3
Exosome complex component RRP40

7

11

Small-scale

0.749

High

966453

EXOSX
Exosome complex component 10

7

11

Small-scale

0.745

High

1284955

MPH6
M-phase phosphoprotein 6

5

5

Small-scale

0.716

High

1285003

RBM7
RNA-binding protein 7

5

5

High-throughput

0.715

High

1284961

DUS23
Dual specificity protein phosphatase 23

4

2

High-throughput

0.709

High

1285001

HBS1L
HBS1-like protein

4

4

Small-scale

0.696

High

1157890

ZCHC8
Zinc finger CCHC domain-containing protein 8

4

3

High-throughput

0.694

High

539091

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

4

1

High-throughput

0.690

High

448769

RU1C
U1 small nuclear ribonucleoprotein C

4

1

High-throughput

0.686

High

823467

PAXI
Paxillin

5

0

High-throughput

0.682

High

147277

TXND9
Thioredoxin domain-containing protein 9

3

1

High-throughput

0.675

High

966618

OTUD4
OTU domain-containing protein 4

3

1

High-throughput

0.675

High

1047034

C1D
Nuclear nucleic acid-binding protein C1D

3

3

High-throughput

0.667

High

966274

TFAP4
Transcription factor AP-4

3

0

High-throughput

0.646

High

1284958

TXD17
Thioredoxin domain-containing protein 17

3

0

High-throughput

0.646

High

1242216

SLAI1
SLAIN motif-containing protein 1

3

0

High-throughput

0.626

High

1242404

MORN4
MORN repeat-containing protein 4

3

0

High-throughput

0.626

High

271164

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

5

High-throughput

0.606

High

326740

SNAI1
Zinc finger protein SNAI1

2

1

High-throughput

0.606

High

567871

HXB9
Homeobox protein Hox-B9

2

1

High-throughput

0.606

High

1054788

CASL
Enhancer of filamentation 1

2

1

High-throughput

0.606

High

1144740

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

2

High-throughput

0.606

High

1252381

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

1284984

FX4L1
Forkhead box protein D4-like 1

2

3

High-throughput

0.606

High

476166

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

High-throughput

0.595

High

1075718

SF01
Splicing factor 1

1

0

High-throughput

0.589

High

1219811

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.589

High

210191

PRC1
Protein regulator of cytokinesis 1

2

1

High-throughput

0.586

High

553383

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

651899

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

721108

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

786996

MTREX
Exosome RNA helicase MTR4

2

12

High-throughput

0.584

High

1056925

MDC1
Mediator of DNA damage checkpoint protein 1

2

2

High-throughput

0.584

High

715082

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

1

High-throughput

0.584

High

1284963

PDIP3
Polymerase delta-interacting protein 3

2

1

High-throughput

0.584

High

146693

SOCS7
Suppressor of cytokine signaling 7

2

0

High-throughput

0.580

High

278316

PIAS2
E3 SUMO-protein ligase PIAS2

2

0

High-throughput

0.580

High

303806

RPP14
Ribonuclease P protein subunit p14

2

0

High-throughput

0.580

High

777903

RFC5
Replication factor C subunit 5

2

0

High-throughput

0.580

High

874316

GEM
GTP-binding protein GEM

2

0

High-throughput

0.580

High

1012303

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1242823

CNNM3
Metal transporter CNNM3

2

0

High-throughput

0.580

High

1284946

PF21A
PHD finger protein 21A

2

0

High-throughput

0.580

High

1284948

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1284949

MACIR
Macrophage immunometabolism regulator

2

0

High-throughput

0.580

High

1284950

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1284962

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1284977

MYOZ1
Myozenin-1

2

0

High-throughput

0.580

High

1284998

RASD1
Dexamethasone-induced Ras-related protein 1

2

0

High-throughput

0.580

High

1285002

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

0

High-throughput

0.580

High

547840

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

3

High-throughput

0.573

High

1075150

TCEA2
Transcription elongation factor A protein 2

1

1

High-throughput

0.573

High

370165

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

903765

LMO4
LIM domain transcription factor LMO4

2

1

High-throughput

0.553

High

981680

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

1053344

FRG1
Protein FRG1

1

0

High-throughput

0.549

High

1259377

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.549

High

659731

RXRB
Retinoic acid receptor RXR-beta

1

8

High-throughput

0.541

High

1050882

DPYL1
Dihydropyrimidinase-related protein 1

1

3

High-throughput

0.541

High

585522

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

2

High-throughput

0.536

High

796622

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

806112

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

983648

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

1284966

AICDA
Single-stranded DNA cytosine deaminase

1

3

Small-scale

0.536

High

1135769

Q5TAL4
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.515

High

1201520

Q86VL0
TCEA2 protein

1

1

High-throughput

0.515

High

418527

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

786070

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

1254746

BRSK1
Serine/threonine-protein kinase BRSK1

1

0

High-throughput

0.513

High

1284971

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

1284979

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

1284995

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

127121

FOXN3
Forkhead box protein N3

1

3

High-throughput

0.508

High

167710

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

3

High-throughput

0.508

High

1284968

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.508

High

1284973

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.508

High

1284975

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

2

High-throughput

0.508

High

1284994

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

3

High-throughput

0.508

High

1255155

CABL1
CDK5 and ABL1 enzyme substrate 1

1

0

High-throughput

0.493

High

644305

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.486

High

1284983

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.486

High

1284992

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.486

High

1285004

FHOD1
FH1/FH2 domain-containing protein 1

1

0

High-throughput

0.486

High

267041

SRS10
Serine/arginine-rich splicing factor 10

1

2

High-throughput

0.481

High

271607

ERAL1
GTPase Era, mitochondrial

1

4

High-throughput

0.481

High

300226

PRP6
Pre-mRNA-processing factor 6

1

5

High-throughput

0.481

High

446734

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.481

High

613545

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.481

High

927994

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

2

High-throughput

0.481

High

1039753

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.481

High

1133913

RM02
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.481

High

1224385

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.481

High

1235764

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

2

High-throughput

0.481

High

1262974

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

7

High-throughput

0.481

High

1284960

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

3

High-throughput

0.481

High

1284964

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.481

High

1284972

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

2

High-throughput

0.481

High

1284974

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.481

High

1284986

RBM22
Pre-mRNA-splicing factor RBM22

1

3

High-throughput

0.481

High

1284989

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.481

High

122925

MEN1
Menin

1

3

High-throughput

0.479

High

237287

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

3

High-throughput

0.479

High

295102

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

298706

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

322979

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

387263

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

801928

RECQ1
ATP-dependent DNA helicase Q1

1

4

High-throughput

0.479

High

857008

THOP1
Thimet oligopeptidase

1

3

High-throughput

0.479

High

908930

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

918592

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

952528

H33
Histone H3.3

1

1

High-throughput

0.479

High

1022170

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

1029712

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1080214

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

1085874

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

1167949

GGYF2
GRB10-interacting GYF protein 2

1

3

High-throughput

0.479

High

1171142

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1256321

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1267072

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1269316

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1284951

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1284956

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1284969

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1284982

ANLN
Anillin

1

3

High-throughput

0.479

High

1284985

DCA13
DDB1- and CUL4-associated factor 13

1

5

Small-scale

0.479

High

1284988

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.479

High

1284991

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1260499

Q8WUT1
POLDIP3 protein

1

1

High-throughput

0.470

High

1262018

Q8WVZ3
MORN repeat containing 4

1

1

High-throughput

0.470

High

401029

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.460

High

760220

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.460

High

920814

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.460

High

942857

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.460

High

948899

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.460

High

997844

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.460

High

1019588

ILF2
Interleukin enhancer-binding factor 2

1

0

High-throughput

0.460

High

1113901

TBRG1
Transforming growth factor beta regulator 1

1

0

High-throughput

0.460

High

1122399

SGO2
Shugoshin 2

1

0

High-throughput

0.460

High

1220026

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.460

High

1242421

CA131
Uncharacterized protein C1orf131

1

0

High-throughput

0.460

High

1284947

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.460

High

1284954

UIF
UAP56-interacting factor

1

0

High-throughput

0.460

High

1284957

PKP2
Plakophilin-2

1

0

High-throughput

0.460

High

1284970

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.460

High

1284990

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.460

High

1284997

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.460

High

309807

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.458

High

325843

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

749760

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

847596

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1063542

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1284959

MET22
Methyltransferase-like protein 22

1

0

High-throughput

0.458

High

1284987

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1284993

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1040943

MTMR3
Myotubularin-related protein 3

1

1

Small-scale

0.457

High

402328

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

1153327

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.445

High

945312

PRR3
Proline-rich protein 3

1

1

High-throughput

0.439

High

1201583

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.437

High

1284976

DNJC4
DnaJ homolog subfamily C member 4

1

2

High-throughput

0.437

High

1284996

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

1205596

F90A1
Protein FAM90A1

3

0

High-throughput

0.352

High

1056488

KCJ11
ATP-sensitive inward rectifier potassium channel 11

2

0

High-throughput

0.316

High

1160225

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

1284953

F161B
Protein FAM161B

2

0

High-throughput

0.316

High

1284965

HPLN2
Hyaluronan and proteoglycan link protein 2

2

0

High-throughput

0.316

High

1284967

SPC1L
Speriolin-like protein

2

0

High-throughput

0.316

High

594942

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.299

High

1205166

CONA1

1

0

High-throughput

0.299

High

1188

GVQW2
Putative uncharacterized protein CCDC28A-AS1

1

0

High-throughput

0.251

Low

1084286

CCL14
C-C motif chemokine 14

1

0

High-throughput

0.251

Low

1284952

DAA10
Dynein axonemal assembly factor 10

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024