Protein: A4
Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]

Gene: A4, App
Organism: Mus musculus
Interactions: 189
UniProt ID: P12023

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000278 - mitotic cell cycle
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001774 - microglial cell activation
GO:0001878 - response to yeast

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

517625

APLP1
Amyloid beta precursor like protein 1

2

12

Small-scale

0.806

High

517626

APLP2
Amyloid beta precursor like protein 2

2

12

Small-scale

0.789

High

517723

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

13

Small-scale

0.776

High

517618

DAB1
Disabled homolog 1

2

17

Small-scale

0.743

High

517622

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

2

12

Small-scale

0.737

High

392755

PRIO
Major prion protein

4

3

Small-scale

0.689

High

517623

CBPE
Carboxypeptidase E

1

1

Small-scale

0.665

High

517713

APBB1
Amyloid beta precursor protein binding family B member 1

1

15

Small-scale

0.653

High

517621

DAB2
Disabled homolog 2

1

16

Small-scale

0.647

High

517574

A4
Amyloid-beta precursor protein

1

14

Small-scale

0.618

High

517640

SHC3
SHC-transforming protein 3

1

20

Small-scale

0.618

High

517715

NUMB
Protein numb homolog

1

16

Small-scale

0.618

High

517578

CALR
Calreticulin

2

3

Small-scale

0.601

High

517679

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

1

15

Small-scale

0.590

High

517702

APBB2
Amyloid beta precursor protein binding family B member 2

1

15

Small-scale

0.590

High

517705

CSTN1
Calsyntenin-1

2

3

Small-scale

0.588

High

517638

RELN
Reelin

2

5

Small-scale

0.584

High

517598

EPHB2
Ephrin type-B receptor 2

1

11

Small-scale

0.578

High

437588

APOE
Apolipoprotein E

2

4

Small-scale

0.571

High

291358

SORL
Sortilin-related receptor

2

15

Small-scale

0.566

High

517720

CHIP
E3 ubiquitin-protein ligase CHIP

2

3

Small-scale

0.563

High

517706

STX12
Syntaxin-12

2

5

Small-scale

0.553

High

193542

CALU
Calumenin

1

3

Small-scale

0.515

High

353354

THY1
Thy-1 membrane glycoprotein

1

1

Small-scale

0.515

High

435910

ENPL
Endoplasmin

1

3

Small-scale

0.515

High

517576

CNTN1
Contactin-1

1

8

Small-scale

0.515

High

517577

NCAM1
Neural cell adhesion molecule 1

1

11

Small-scale

0.515

High

517582

BIP
Endoplasmic reticulum chaperone BiP

1

5

Small-scale

0.515

High

517583

CYTC
Cystatin-C

1

5

Small-scale

0.515

High

517584

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

Small-scale

0.515

High

517588

OAT
Ornithine aminotransferase, mitochondrial

1

2

Small-scale

0.515

High

517589

CALX
Calnexin

1

3

Small-scale

0.515

High

517659

NFASC
Neurofascin

1

10

Small-scale

0.515

High

517669

RCN2
Reticulocalbin-2

1

3

Small-scale

0.515

High

517683

SPON1
Spondin-1

1

10

Small-scale

0.515

High

517690

PDIA6
Protein disulfide-isomerase A6

1

8

Small-scale

0.515

High

517691

CSTN3
Calsyntenin-3

1

7

Small-scale

0.515

High

517697

ERP44
Endoplasmic reticulum resident protein 44

1

8

Small-scale

0.515

High

517698

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

3

Small-scale

0.515

High

517704

IPP2
Protein phosphatase inhibitor 2

1

1

Small-scale

0.515

High

517711

HYOU1
Hypoxia up-regulated protein 1

1

6

Small-scale

0.515

High

517716

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

4

Small-scale

0.515

High

517721

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

Small-scale

0.515

High

517722

E41L3
Band 4.1-like protein 3

1

6

Small-scale

0.515

High

57059

A2AFG8
L1 cell adhesion molecule

1

8

Small-scale

0.501

High

426889

TTHY
Transthyretin

1

1

Small-scale

0.501

High

517672

CRBN
Protein cereblon

1

1

Small-scale

0.501

High

517677

GGA1
ADP-ribosylation factor-binding protein GGA1

1

6

Small-scale

0.501

High

517665

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.493

High

517590

SYT1
Synaptotagmin-1

2

6

Small-scale

0.492

High

517591

SYT2
Synaptotagmin-2

2

6

Small-scale

0.492

High

517602

SNP25
Synaptosomal-associated protein 25

2

1

Small-scale

0.492

High

517612

VAMP2
Vesicle-associated membrane protein 2

2

3

Small-scale

0.492

High

517632

VGLU1
Vesicular glutamate transporter 1

2

4

Small-scale

0.492

High

517662

SV2B
Synaptic vesicle glycoprotein 2B

2

3

Small-scale

0.492

High

517709

SV2A
Synaptic vesicle glycoprotein 2A

2

3

Small-scale

0.492

High

192182

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

11

Small-scale

0.479

High

223024

SYUA
Alpha-synuclein

1

4

Small-scale

0.479

High

292577

ITM2B
Integral membrane protein 2B

1

4

Small-scale

0.479

High

345600

FOS
Protein c-Fos

1

10

Small-scale

0.479

High

351121

EGF
Pro-epidermal growth factor

1

15

Small-scale

0.479

High

404112

JUN
Transcription factor Jun

1

7

Small-scale

0.479

High

517575

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

1

High-throughput

0.479

High

517581

GNAO

1

6

Small-scale

0.479

High

517586

RGRF1
Ras-specific guanine nucleotide-releasing factor 1

1

7

Small-scale

0.479

High

517613

RANB9
Ran-binding protein 9

1

4

Small-scale

0.479

High

517614

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

Small-scale

0.479

High

517616

SPRL1
SPARC-like protein 1

1

2

Small-scale

0.479

High

517620

JDP2
Jun dimerization protein 2

1

6

Small-scale

0.479

High

517627

CLUS
Clusterin

1

2

Small-scale

0.479

High

517628

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

517635

Q3UH16
Kinesin-like protein KIF1A

1

9

Small-scale

0.479

High

517639

USF1
Upstream stimulatory factor 1

1

8

Small-scale

0.479

High

517641

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.479

High

517642

NBL1
Neuroblastoma suppressor of tumorigenicity 1

1

1

Small-scale

0.479

High

517643

DLG4
Disks large homolog 4

1

3

Small-scale

0.479

High

517647

USF2
Upstream stimulatory factor 2

1

8

Small-scale

0.479

High

517650

SORT
Sortilin

1

5

Small-scale

0.479

High

517660

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

4

Small-scale

0.479

High

517664

FLRT3
Leucine-rich repeat transmembrane protein FLRT3

1

6

Small-scale

0.479

High

517707

S40A1
Solute carrier family 40 member 1

1

1

Small-scale

0.479

High

517726

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

0

Small-scale

0.471

High

517687

METK1
S-adenosylmethionine synthase isoform type-1

1

1

Small-scale

0.470

High

292402

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

517609

RB11A
Ras-related protein Rab-11A

1

4

Small-scale

0.445

High

45694

A0A1I9GFB9
TGF-b1-induced anti-apoptotic factor 1

1

1

Small-scale

0.437

High

517634

Q3U2G2
Heat shock 70 kDa protein 4

1

4

Small-scale

0.437

High

56787

CUL4B
Cullin-4B

1

6

Small-scale

0.408

High

57457

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

Small-scale

0.408

High

58196

FXL16
F-box/LRR-repeat protein 16

1

3

Small-scale

0.408

High

139534

STXB1
Syntaxin-binding protein 1

1

3

Small-scale

0.408

High

192838

STX1A
Syntaxin-1A

1

6

Small-scale

0.408

High

193217

VIAAT
Vesicular inhibitory amino acid transporter

1

1

Small-scale

0.408

High

193513

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.408

High

223071

SNG1
Synaptogyrin-1

1

1

Small-scale

0.408

High

291844

CSN3
COP9 signalosome complex subunit 3

1

4

Small-scale

0.408

High

291854

CSN4
COP9 signalosome complex subunit 4

1

1

Small-scale

0.408

High

291864

CSN6
COP9 signalosome complex subunit 6

1

3

Small-scale

0.408

High

292462

SYN1
Synapsin-1

1

2

Small-scale

0.408

High

292713

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

1

Small-scale

0.408

High

497912

TAU
Microtubule-associated protein tau

1

4

Small-scale

0.408

High

517579

AP2A1
AP-2 complex subunit alpha-1

1

4

Small-scale

0.408

High

517580

AP2A2
AP-2 complex subunit alpha-2

1

4

Small-scale

0.408

High

517592

NSF
Vesicle-fusing ATPase

1

2

Small-scale

0.408

High

517593

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.408

High

517594

VATA
V-type proton ATPase catalytic subunit A

1

1

Small-scale

0.408

High

517595

VATE1
V-type proton ATPase subunit E 1

1

1

Small-scale

0.408

High

517597

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.408

High

517603

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.408

High

517604

CSN2
COP9 signalosome complex subunit 2

1

5

Small-scale

0.408

High

517605

STX1B
Syntaxin-1B

1

6

Small-scale

0.408

High

517606

PRS4
26S proteasome regulatory subunit 4

1

5

Small-scale

0.408

High

517607

PRS8
26S proteasome regulatory subunit 8

1

5

Small-scale

0.408

High

517611

RAB3A
Ras-related protein Rab-3A

1

8

Small-scale

0.408

High

517615

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

Small-scale

0.408

High

517617

AP2M1
AP-2 complex subunit mu

1

1

Small-scale

0.408

High

517619

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

1

1

Small-scale

0.408

High

517624

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

4

Small-scale

0.408

High

517629

CUL4A
Cullin-4A

1

6

Small-scale

0.408

High

517630

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.408

High

517636

UBR3
E3 ubiquitin-protein ligase UBR3

1

1

Small-scale

0.408

High

517637

GRB2
Growth factor receptor-bound protein 2

1

11

Small-scale

0.408

High

517644

SYPH
Synaptophysin

1

2

Small-scale

0.408

High

517645

VAMP1
Vesicle-associated membrane protein 1

1

3

Small-scale

0.408

High

517646

SYN2
Synapsin-2

1

2

Small-scale

0.408

High

517648

SV2C
Synaptic vesicle glycoprotein 2C

1

3

Small-scale

0.408

High

517649

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

Small-scale

0.408

High

517651

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O

1

5

Small-scale

0.408

High

517652

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

Small-scale

0.408

High

517654

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

Small-scale

0.408

High

517655

OTUB1
Ubiquitin thioesterase OTUB1

1

2

Small-scale

0.408

High

517656

DCAF5
DDB1- and CUL4-associated factor 5

1

5

Small-scale

0.408

High

517657

UBR5
E3 ubiquitin-protein ligase UBR5

1

6

Small-scale

0.408

High

517658

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

3

Small-scale

0.408

High

517663

SYNPR
Synaptoporin

1

2

Small-scale

0.408

High

517666

MAL2
Protein MAL2

1

1

Small-scale

0.408

High

517668

VGLU2
Vesicular glutamate transporter 2

1

4

Small-scale

0.408

High

517670

CSN7B
COP9 signalosome complex subunit 7b

1

4

Small-scale

0.408

High

517673

TRI32
E3 ubiquitin-protein ligase TRIM32

1

4

Small-scale

0.408

High

517674

SCAM1
Secretory carrier-associated membrane protein 1

1

3

Small-scale

0.408

High

517675

HECW1
E3 ubiquitin-protein ligase HECW1

1

4

Small-scale

0.408

High

517676

DCAF8
DDB1- and CUL4-associated factor 8

1

4

Small-scale

0.408

High

517678

SNG3
Synaptogyrin-3

1

1

Small-scale

0.408

High

517680

UBQL1
Ubiquilin-1

1

8

Small-scale

0.408

High

517681

MIB2
E3 ubiquitin-protein ligase MIB2

1

1

Small-scale

0.408

High

517686

RAB14
Ras-related protein Rab-14

1

6

Small-scale

0.408

High

517688

SYT17
Synaptotagmin-17

1

6

Small-scale

0.408

High

517689

SYT12
Synaptotagmin-12

1

6

Small-scale

0.408

High

517692

PARK7
Parkinson disease protein 7 homolog

1

1

Small-scale

0.408

High

517693

UBQL4
Ubiquilin-4

1

9

Small-scale

0.408

High

517699

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

5

Small-scale

0.408

High

517700

SNAA
Alpha-soluble NSF attachment protein

1

3

Small-scale

0.408

High

517703

FBX3
F-box only protein 3

1

1

Small-scale

0.408

High

517708

RNF14
E3 ubiquitin-protein ligase RNF14

1

4

Small-scale

0.408

High

517710

SCAM5
Secretory carrier-associated membrane protein 5

1

3

Small-scale

0.408

High

517712

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.408

High

517714

UBQL2
Ubiquilin-2

1

9

Small-scale

0.408

High

517717

SYT5
Synaptotagmin-5

1

6

Small-scale

0.408

High

517718

VINEX
Vinexin

1

5

Small-scale

0.408

High

517727

ARI1
E3 ubiquitin-protein ligase ARIH1

1

4

Small-scale

0.408

High

517596

VA0D1
V-type proton ATPase subunit d 1

1

0

Small-scale

0.391

High

517601

VATD
V-type proton ATPase subunit D

1

0

Small-scale

0.391

High

517610

VATB2
V-type proton ATPase subunit B, brain isoform

1

0

Small-scale

0.391

High

517633

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.391

High

517667

S6A17
Sodium-dependent neutral amino acid transporter SLC6A17

1

0

Small-scale

0.391

High

517671

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.391

High

517682

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.391

High

517696

VATF
V-type proton ATPase subunit F

1

0

Small-scale

0.391

High

517725

VATC1
V-type proton ATPase subunit C 1

1

0

Small-scale

0.391

High

102345

G3UXW9
G protein pathway suppressor 1

1

3

Small-scale

0.373

High

192427

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.373

High

192887

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

Small-scale

0.373

High

193113

SCAM3
Secretory carrier-associated membrane protein 3

1

3

Small-scale

0.373

High

517585

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

4

Small-scale

0.373

High

517587

SNAB
Beta-soluble NSF attachment protein

1

3

Small-scale

0.373

High

517599

PRS6B
26S proteasome regulatory subunit 6B

1

5

Small-scale

0.373

High

517600

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

5

Small-scale

0.373

High

517608

PRS10
26S proteasome regulatory subunit 10B

1

5

Small-scale

0.373

High

517631

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

Small-scale

0.373

High

517653

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

2

Small-scale

0.373

High

517661

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

4

Small-scale

0.373

High

517685

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

Small-scale

0.373

High

517695

CSN7A
COP9 signalosome complex subunit 7a

1

4

Small-scale

0.373

High

517701

AP2B1
AP-2 complex subunit beta

1

6

Small-scale

0.373

High

517719

VATG2
V-type proton ATPase subunit G 2

1

1

Small-scale

0.373

High

517724

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

4

Small-scale

0.373

High

517684

FBX21
F-box only protein 21

1

0

Small-scale

0.213

Low

517694

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

Small-scale

0.213

Low


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Last updated: 15 Jul 2024