Protein: PAF1
RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)

Gene: PAF1
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q8N7H5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000993 - RNA polymerase II complex binding
GO:0001650 - fibrillar center
GO:0001711 - endodermal cell fate commitment
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158281

CDC73
Parafibromin

16

3

Small-scale

0.985

High

1237136

LEO1
RNA polymerase-associated protein LEO1

14

9

Small-scale

0.984

High

1160942

CTR9
RNA polymerase-associated protein CTR9 homolog

11

6

Small-scale

0.980

High

1161397

SKI3
Superkiller complex protein 3

2

5

Small-scale

0.789

High

1237151

SKI8
Superkiller complex protein 8

7

5

Small-scale

0.745

High

624961

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

2

Small-scale

0.711

High

1237139

RTF1
RNA polymerase-associated protein RTF1 homolog

5

2

Small-scale

0.709

High

612997

TCEA1
Transcription elongation factor A protein 1

3

1

Small-scale

0.676

High

124014

SPT5H
Transcription elongation factor SPT5

2

2

High-throughput

0.628

High

124517

TULP2
Tubby-related protein 2

2

1

High-throughput

0.628

High

974499

ENL
Protein ENL

2

2

Small-scale

0.624

High

1062582

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.618

High

844153

FXR2
RNA-binding protein FXR2

2

0

High-throughput

0.613

High

1138190

BRE1A
E3 ubiquitin-protein ligase BRE1A

2

2

Small-scale

0.611

High

881532

ARL4C
ADP-ribosylation factor-like protein 4C

2

0

High-throughput

0.602

High

1222192

YAF2
YY1-associated factor 2

2

0

High-throughput

0.602

High

1222468

SLX4
Structure-specific endonuclease subunit SLX4

2

2

High-throughput

0.601

High

975284

KMT2A
Histone-lysine N-methyltransferase 2A

1

1

Small-scale

0.597

High

841813

CDK9
Cyclin-dependent kinase 9

2

2

Small-scale

0.594

High

726932

FUS
RNA-binding protein FUS

2

0

High-throughput

0.585

High

228059

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

244667

BRD4
Bromodomain-containing protein 4

2

2

Small-scale

0.584

High

282964

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

3

High-throughput

0.584

High

347335

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.584

High

455659

PARP1
Poly [ADP-ribose] polymerase 1

2

3

High-throughput

0.584

High

985992

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

1

Small-scale

0.584

High

1237172

SP16H
FACT complex subunit SPT16

2

1

Small-scale

0.584

High

897573

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

Small-scale

0.576

High

1237138

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

1

High-throughput

0.574

High

851844

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

0

Small-scale

0.561

High

559833

H12
Histone H1.2

1

1

Small-scale

0.561

High

934985

H31
Histone H3.1

1

2

Small-scale

0.561

High

388595

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.558

High

850753

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

0

High-throughput

0.547

High

1031687

GRB10
Growth factor receptor-bound protein 10

2

0

High-throughput

0.547

High

262510

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

417357

ENOA
Alpha-enolase

1

1

High-throughput

0.541

High

335470

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.536

High

403285

LA
Lupus La protein

1

1

High-throughput

0.536

High

420858

H2B1J
Histone H2B type 1-J

1

2

High-throughput

0.536

High

449769

HMGB1
High mobility group protein B1

1

5

High-throughput

0.536

High

508617

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

513602

PYC
Pyruvate carboxylase, mitochondrial

1

4

High-throughput

0.536

High

586857

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

718990

PHB1
Prohibitin 1

1

2

High-throughput

0.536

High

818253

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

996775

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

1024049

ACACA
Acetyl-CoA carboxylase 1

1

4

High-throughput

0.536

High

1087262

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1237144

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1237153

SENP3
Sentrin-specific protease 3

1

2

High-throughput

0.536

High

1237160

AGO4
Protein argonaute-4

1

1

High-throughput

0.536

High

1237171

NGN3
Neurogenin-3

1

1

High-throughput

0.536

High

831494

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.527

High

123651

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

229961

NUAK1
NUAK family SNF1-like kinase 1

1

0

High-throughput

0.513

High

446707

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

448741

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

539059

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

601308

VDAC1
Voltage-dependent anion-selective channel protein 1

1

0

High-throughput

0.513

High

911898

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

913921

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

916695

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

943133

KC1G2
Casein kinase I isoform gamma-2

1

0

High-throughput

0.513

High

1022547

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.513

High

1084533

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1125669

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1192588

PXK
PX domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

1237134

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1237137

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

0

High-throughput

0.513

High

1237148

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1237156

CB39L
Calcium-binding protein 39-like

1

0

High-throughput

0.513

High

902674

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

976479

ERCC6
DNA excision repair protein ERCC-6

1

6

High-throughput

0.501

High

1235310

MS3L1
MSL complex subunit 3

1

1

Small-scale

0.501

High

236799

CCNT1
Cyclin-T1

1

1

Small-scale

0.500

High

277525

CCNK
Cyclin-K

1

1

Small-scale

0.500

High

1237163

CDK12
Cyclin-dependent kinase 12

1

2

Small-scale

0.500

High

398274

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

3

High-throughput

0.489

High

398373

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.489

High

1237147

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.489

High

1237158

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.489

High

1148048

MSL1
Male-specific lethal 1 homolog

1

0

Small-scale

0.480

High

1237155

KAT8
Histone acetyltransferase KAT8

1

0

Small-scale

0.480

High

1237159

MSL2
E3 ubiquitin-protein ligase MSL2

1

0

Small-scale

0.480

High

46896

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.479

High

133567

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

151431

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

5

Small-scale

0.479

High

162998

XPO1
Exportin-1

1

2

High-throughput

0.479

High

179722

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

253752

AUXI
Auxilin

1

2

High-throughput

0.479

High

322883

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

490067

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

2

High-throughput

0.479

High

553192

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

569877

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

651692

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

665918

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

1

Small-scale

0.479

High

668830

PML
Protein PML

1

1

Small-scale

0.479

High

720919

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

788049

AF9
Protein AF-9

1

1

Small-scale

0.479

High

802461

ATRX
Transcriptional regulator ATRX

1

6

Small-scale

0.479

High

824190

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

826315

CDK8
Cyclin-dependent kinase 8

1

2

High-throughput

0.479

High

882430

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

917599

H4
Histone H4

1

2

High-throughput

0.479

High

971269

H11
Histone H1.1

1

1

Small-scale

0.479

High

998889

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1024490

CAF1A
Chromatin assembly factor 1 subunit A

1

2

Small-scale

0.479

High

1051986

ELOA1
Elongin-A

1

1

Small-scale

0.479

High

1055427

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.479

High

1056889

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1059737

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

1085823

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1116391

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

1153872

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

1170822

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1221567

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1237135

NUP43
Nucleoporin Nup43

1

5

High-throughput

0.479

High

1237140

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1237141

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1237142

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

1237145

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

1237146

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

1237150

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1237152

Q9H4D1
Protein kinase

1

3

High-throughput

0.479

High

1237154

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1237165

DNM3B
DNA

1

1

Small-scale

0.479

High

1237166

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1237168

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

1237173

DNM3A
DNA

1

1

Small-scale

0.479

High

149053

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

233542

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

295021

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

387108

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

637946

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

652920

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

659304

DUS1
Dual specificity protein phosphatase 1

1

0

Small-scale

0.458

High

737923

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

750354

COIL
Coilin

1

0

High-throughput

0.458

High

808775

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

922256

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

931737

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

974610

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

976241

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.458

High

986944

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

1064488

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1134058

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1200492

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1233889

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

1237143

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1237149

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1237162

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1237164

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1237170

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

883563

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1130324

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1237161

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

5

High-throughput

0.445

High

100951

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

385169

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

908823

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1074480

SKI2
Superkiller complex protein 2

1

1

High-throughput

0.437

High

1161714

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.437

High

1188563

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

295649

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.426

High

1237157

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1237169

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.426

High

71182

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

278642

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

537218

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.279

Low

579564

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.279

Low

594929

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

828833

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

872060

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.279

Low

1237133

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

62157

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1231774

FA43A
Protein FAM43A

1

0

Small-scale

0.249

Low

1237167

TES
Testin

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024