Protein: AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)

Gene: AAPK2, PRKAA2
Organism: Homo sapiens
Interactions: 240
UniProt ID: P54646

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004679 - AMP-activated protein kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

870991

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

15

19

Small-scale

0.985

High

212375

AAKB2
5'-AMP-activated protein kinase subunit beta-2

12

20

Small-scale

0.983

High

871508

AAKB1
5'-AMP-activated protein kinase subunit beta-1

8

20

High-throughput

0.971

High

871497

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

7

18

High-throughput

0.966

High

871462

LMBL3
Lethal(3)malignant brain tumor-like protein 3

4

2

High-throughput

0.904

High

871496

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

4

19

High-throughput

0.903

High

262244

ULK1
Serine/threonine-protein kinase ULK1

3

18

Small-scale

0.847

High

871465

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

2

19

High-throughput

0.811

High

679218

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

4

High-throughput

0.783

High

840652

DYN2
Dynamin-2

2

1

High-throughput

0.783

High

871377

IKZF1
DNA-binding protein Ikaros

2

3

High-throughput

0.783

High

871396

ZSC23
Zinc finger and SCAN domain-containing protein 23

2

1

High-throughput

0.783

High

871398

USH1G
pre-mRNA splicing regulator USH1G

2

5

High-throughput

0.783

High

871413

STAC2
SH3 and cysteine-rich domain-containing protein 2

2

6

High-throughput

0.783

High

871438

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

1

High-throughput

0.783

High

871464

KI16B
Kinesin-like protein KIF16B

2

3

High-throughput

0.783

High

871485

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

1

High-throughput

0.783

High

871495

ZN212
Zinc finger protein 212

2

2

High-throughput

0.783

High

871502

IKZF3
Zinc finger protein Aiolos

2

4

High-throughput

0.783

High

871372

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

18

Small-scale

0.776

High

226967

PRKN
E3 ubiquitin-protein ligase parkin

2

7

Small-scale

0.768

High

871360

BORG5
Cdc42 effector protein 1

2

0

High-throughput

0.742

High

871458

TIFA
TRAF-interacting protein with FHA domain-containing protein A

2

0

High-throughput

0.742

High

310390

EPM2A
Laforin

1

1

Small-scale

0.740

High

436692

GLI1
Zinc finger protein GLI1

1

3

High-throughput

0.740

High

871385

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.740

High

871407

KIF24
Kinesin-like protein KIF24

1

6

High-throughput

0.740

High

871453

RBPMS
RNA-binding protein with multiple splicing

1

1

High-throughput

0.740

High

871490

ABI2
Abl interactor 2

4

9

High-throughput

0.705

High

871420

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.702

High

871441

ZN397
Zinc finger protein 397

1

0

High-throughput

0.702

High

871400

FND3B
Fibronectin type III domain-containing protein 3B

2

1

High-throughput

0.700

High

871389

TRIP6
Thyroid receptor-interacting protein 6

3

2

Small-scale

0.695

High

871466

DCR1C
Protein artemis

4

2

High-throughput

0.694

High

230850

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

16

High-throughput

0.691

High

312787

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

19

High-throughput

0.691

High

411343

INSR
Insulin receptor

1

12

Small-scale

0.691

High

646025

AVR2A
Activin receptor type-2A

1

1

High-throughput

0.691

High

829440

PPM1F
Protein phosphatase 1F

1

15

Small-scale

0.691

High

835606

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.691

High

871361

SRSF2
Serine/arginine-rich splicing factor 2

1

1

High-throughput

0.691

High

871401

DJC21
DnaJ homolog subfamily C member 21

1

3

High-throughput

0.691

High

871467

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

19

High-throughput

0.691

High

871473

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.691

High

871509

C170B
Centrosomal protein of 170 kDa protein B

1

1

High-throughput

0.691

High

871366

TLE5
TLE family member 5

3

1

High-throughput

0.675

High

871410

LTOR1
Ragulator complex protein LAMTOR1

3

3

Small-scale

0.656

High

871373

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

3

14

High-throughput

0.653

High

871403

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

10

High-throughput

0.650

High

475524

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.647

High

871435

RPTOR
Regulatory-associated protein of mTOR

1

11

Small-scale

0.647

High

871471

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.640

High

871493

STIM2
Stromal interaction molecule 2

4

4

High-throughput

0.638

High

871432

HOMEZ
Homeobox and leucine zipper protein Homez

2

3

High-throughput

0.633

High

871499

CTNA3
Catenin alpha-3

2

1

High-throughput

0.628

High

871363

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.622

High

431689

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.618

High

438026

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.618

High

636288

DNJB1
DnaJ homolog subfamily B member 1

1

5

High-throughput

0.618

High

779088

CCNF
Cyclin-F

1

1

High-throughput

0.618

High

844838

RAB7A
Ras-related protein Rab-7a

1

10

High-throughput

0.618

High

871376

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

Small-scale

0.618

High

871392

STK11
Serine/threonine-protein kinase STK11

1

18

Small-scale

0.618

High

871414

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.618

High

871447

DNJA4
DnaJ homolog subfamily A member 4

1

4

High-throughput

0.618

High

871448

PPM1E
Protein phosphatase 1E

1

18

Small-scale

0.618

High

871494

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.618

High

871399

AMOT
Angiomotin

2

14

High-throughput

0.614

High

871358

PRKDC
DNA-dependent protein kinase catalytic subunit

2

4

Small-scale

0.611

High

871408

SPD2A
SH3 and PX domain-containing protein 2A

2

5

High-throughput

0.611

High

871417

SYPM
Probable proline--tRNA ligase, mitochondrial

2

1

High-throughput

0.611

High

871472

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

4

High-throughput

0.611

High

871487

SMYD2
N-lysine methyltransferase SMYD2

2

1

High-throughput

0.611

High

125279

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

8

High-throughput

0.606

High

150339

CDX4
Homeobox protein CDX-4

2

1

High-throughput

0.606

High

208336

SPY1
Protein sprouty homolog 1

2

1

High-throughput

0.606

High

264285

GGYF1
GRB10-interacting GYF protein 1

2

1

High-throughput

0.606

High

275182

GRAP2
GRB2-related adapter protein 2

2

7

High-throughput

0.606

High

445022

K1C16
Keratin, type I cytoskeletal 16

2

2

High-throughput

0.606

High

519708

MYCL
Protein L-Myc

2

6

High-throughput

0.606

High

781873

PERI
Peripherin

2

7

High-throughput

0.606

High

871351

KR109
Keratin-associated protein 10-9

2

3

High-throughput

0.606

High

871367

GOGA2
Golgin subfamily A member 2

2

13

High-throughput

0.606

High

871387

SKI2
Superkiller complex protein 2

2

3

High-throughput

0.606

High

871388

PCH2
Pachytene checkpoint protein 2 homolog

2

5

High-throughput

0.606

High

871416

KCTD9
BTB/POZ domain-containing protein KCTD9

2

1

High-throughput

0.606

High

871426

RASL3
RAS protein activator like-3

2

3

High-throughput

0.606

High

871429

KRA13
Keratin-associated protein 1-3

2

2

High-throughput

0.606

High

871434

ABI1
Abl interactor 1

2

8

High-throughput

0.606

High

871451

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

10

High-throughput

0.606

High

871455

ARRD3
Arrestin domain-containing protein 3

2

4

High-throughput

0.606

High

871469

LZTS2
Leucine zipper putative tumor suppressor 2

2

10

High-throughput

0.606

High

871477

SLAP2
Src-like-adapter 2

2

8

High-throughput

0.606

High

871479

VP37B
Vacuolar protein sorting-associated protein 37B

2

1

High-throughput

0.606

High

871491

APC11
Anaphase-promoting complex subunit 11

2

1

High-throughput

0.606

High

871492

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

2

10

High-throughput

0.606

High

871505

AMOL2
Angiomotin-like protein 2

2

9

High-throughput

0.606

High

871513

EMIL1
EMILIN-1

2

8

High-throughput

0.606

High

871514

USH1C
Harmonin

2

3

High-throughput

0.606

High

871483

CIP1
E3 ubiquitin-protein ligase CCNB1IP1

2

0

High-throughput

0.601

High

871352

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.589

High

871395

ZXDC
Zinc finger protein ZXDC

1

0

High-throughput

0.586

High

683920

1433S
14-3-3 protein sigma

2

20

High-throughput

0.584

High

307517

EPN2
Epsin-2

2

0

High-throughput

0.580

High

473613

CC172
Coiled-coil domain-containing protein 172

2

0

High-throughput

0.580

High

871362

CDR2
Cerebellar degeneration-related protein 2

2

0

High-throughput

0.580

High

871369

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.580

High

871390

NAB2
NGFI-A-binding protein 2

2

0

High-throughput

0.580

High

871405

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.580

High

871412

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.580

High

871419

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.580

High

871460

NRBF2
Nuclear receptor-binding factor 2

2

0

High-throughput

0.580

High

871474

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.580

High

871484

DAAF6
Dynein axonemal assembly factor 6

2

0

High-throughput

0.580

High

871500

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.580

High

871501

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.580

High

871503

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

871512

MOFA1
MORF4 family-associated protein 1

2

0

High-throughput

0.580

High

871383

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

Small-scale

0.578

High

871349

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

17

High-throughput

0.575

High

871433

ULK2
Serine/threonine-protein kinase ULK2

1

19

High-throughput

0.575

High

871475

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

8

Small-scale

0.573

High

871386

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.573

High

871411

HMBX1
Homeobox-containing protein 1

1

3

High-throughput

0.573

High

871418

NT2NA
Notch homolog 2 N-terminal-like protein A

1

3

High-throughput

0.573

High

871427

RFX6
DNA-binding protein RFX6

1

1

High-throughput

0.573

High

871436

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.573

High

871439

USBP1
Harmonin-binding protein USHBP1

1

9

High-throughput

0.573

High

871449

APBP2
Amyloid protein-binding protein 2

1

1

High-throughput

0.573

High

871456

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

1

High-throughput

0.573

High

871507

T22D4
TSC22 domain family protein 4

1

1

High-throughput

0.573

High

403611

AP2A
Transcription factor AP-2-alpha

1

0

Small-scale

0.554

High

871359

NGAL
Neutrophil gelatinase-associated lipocalin

2

1

High-throughput

0.553

High

871397

PKHN1
Pleckstrin homology domain-containing family N member 1

2

1

High-throughput

0.553

High

871489

GOG6A
Golgin subfamily A member 6A

2

12

High-throughput

0.553

High

353394

PIGR
Polymeric immunoglobulin receptor

1

1

High-throughput

0.553

High

871486

MXRA5
Matrix-remodeling-associated protein 5

1

2

High-throughput

0.553

High

121713

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

Small-scale

0.552

High

749280

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.552

High

871504

PPR3C
Protein phosphatase 1 regulatory subunit 3C

1

1

Small-scale

0.552

High

551098

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

871374

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.549

High

871415

KCTD1
BTB/POZ domain-containing protein KCTD1

1

0

High-throughput

0.549

High

871425

NUTM1
NUT family member 1

1

0

High-throughput

0.549

High

124291

DFFA
DNA fragmentation factor subunit alpha

1

1

High-throughput

0.536

High

135411

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

9

High-throughput

0.536

High

298316

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.536

High

396334

APOD
Apolipoprotein D

1

1

High-throughput

0.536

High

724640

GDE
Glycogen debranching enzyme

1

1

High-throughput

0.536

High

822536

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

1

High-throughput

0.536

High

871353

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.536

High

871365

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

2

High-throughput

0.536

High

871382

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.536

High

871402

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

6

High-throughput

0.536

High

871442

FLCN
Folliculin

1

1

High-throughput

0.536

High

871443

RBCC1
RB1-inducible coiled-coil protein 1

1

9

High-throughput

0.536

High

871445

PARD3
Partitioning defective 3 homolog

1

6

High-throughput

0.536

High

871446

FNIP1
Folliculin-interacting protein 1

1

2

High-throughput

0.536

High

871482

M1IP1
Mid1-interacting protein 1

1

1

High-throughput

0.536

High

871498

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

1

High-throughput

0.536

High

871409

Q6FG41
Protein c-Fos

1

2

High-throughput

0.515

High

261982

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.513

High

312222

IPO7
Importin-7

1

0

High-throughput

0.513

High

533658

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.513

High

809854

GLYG
Glycogenin-1

1

0

High-throughput

0.513

High

871391

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.513

High

871430

MGAP
MAX gene-associated protein

1

0

High-throughput

0.513

High

871431

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

871450

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.513

High

871393

RBBP7
Histone-binding protein RBBP7

1

5

Small-scale

0.501

High

281581

WFS1
Wolframin

1

0

High-throughput

0.493

High

660442

GRN
Progranulin

1

0

High-throughput

0.493

High

871506

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

871379

STIM1
Stromal interaction molecule 1

1

4

High-throughput

0.489

High

871461

CERS2
Ceramide synthase 2

1

2

High-throughput

0.489

High

871470

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.489

High

345378

FOS
Protein c-Fos

1

2

High-throughput

0.481

High

657475

TMOD1
Tropomodulin-1

1

2

Small-scale

0.481

High

871350

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.481

High

871357

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.481

High

871423

NRAP
Nebulin-related-anchoring protein

1

3

Small-scale

0.481

High

871454

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

Small-scale

0.481

High

158766

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.480

High

641175

DNMT1
DNA

1

0

Small-scale

0.480

High

217996

PEX1
Peroxisomal ATPase PEX1

1

7

High-throughput

0.479

High

322375

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

515824

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

4

High-throughput

0.479

High

552331

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

590743

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

617825

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.479

High

622238

ALAT1
Alanine aminotransferase 1

1

1

High-throughput

0.479

High

650775

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

683222

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

720063

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

740482

PPARG
Peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.479

High

862984

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

871354

1433E
14-3-3 protein epsilon

1

20

High-throughput

0.479

High

871355

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.479

High

871356

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

871364

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

871368

TRAF2
TNF receptor-associated factor 2

1

8

High-throughput

0.479

High

871370

TRAF1
TNF receptor-associated factor 1

1

5

High-throughput

0.479

High

871371

ACACA
Acetyl-CoA carboxylase 1

1

6

High-throughput

0.479

High

871380

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.479

High

871381

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

871384

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.479

High

871404

AMER1
APC membrane recruitment protein 1

1

1

High-throughput

0.479

High

871422

MGDP1
Magnesium-dependent phosphatase 1

1

1

High-throughput

0.479

High

871444

MORC4
MORC family CW-type zinc finger protein 4

1

2

High-throughput

0.479

High

871452

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

Small-scale

0.479

High

871459

OPTN
Optineurin

1

13

High-throughput

0.479

High

871463

SNX27
Sorting nexin-27

1

5

High-throughput

0.479

High

871476

TXNIP
Thioredoxin-interacting protein

1

4

Small-scale

0.479

High

871478

NOL11
Nucleolar protein 11

1

2

High-throughput

0.479

High

871515

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

2

High-throughput

0.479

High

57674

A2BDD9
AMOT protein

1

9

High-throughput

0.470

High

66270

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

871378

SNW1
SNW domain-containing protein 1

1

0

Small-scale

0.460

High

871440

CS047
Uncharacterized protein C19orf47

1

0

Small-scale

0.460

High

871481

MYOZ1
Myozenin-1

1

0

Small-scale

0.460

High

230593

KATIP
Katanin-interacting protein

1

0

High-throughput

0.458

High

265621

E2F6
Transcription factor E2F6

1

0

High-throughput

0.458

High

768502

TYRP2
L-dopachrome tautomerase

1

0

High-throughput

0.458

High

871375

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.458

High

871394

SMN
Survival motor neuron protein

1

0

High-throughput

0.458

High

871428

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.458

High

871480

MLXPL
Carbohydrate-responsive element-binding protein

1

0

Small-scale

0.458

High

871488

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.458

High

871510

RIPR2
Rho family-interacting cell polarization regulator 2

1

0

High-throughput

0.458

High

871511

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.458

High

47153

A0A6Q8KRG2
Golgin subfamily A member 2

1

12

High-throughput

0.457

High

871457

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

67021

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

271957

CTAG2
Cancer/testis antigen 2

2

0

High-throughput

0.316

High

871406

AVPI1
Arginine vasopressin-induced protein 1

2

0

High-throughput

0.316

High

871421

K1328
Protein hinderin

2

0

High-throughput

0.316

High

871468

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

871437

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

871424

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024