Protein: ECHP
Peroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]

Gene: ECHP, EHHADH
Organism: Homo sapiens
Interactions: 147
UniProt ID: Q08426

Gene Ontology (top 5):
GO:0003857 - 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004165 - delta(3)-delta(2)-enoyl-CoA isomerase activity
GO:0004300 - enoyl-CoA hydratase activity
GO:0005777 - peroxisome
GO:0005782 - peroxisomal matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

175674

TRI18
E3 ubiquitin-protein ligase Midline-1

3

17

High-throughput

0.654

High

995553

KCTD6
BTB/POZ domain-containing protein KCTD6

3

2

High-throughput

0.640

High

995558

TRI41
E3 ubiquitin-protein ligase TRIM41

4

4

High-throughput

0.622

High

536801

TRI27
Zinc finger protein RFP

2

4

High-throughput

0.611

High

569073

DESM
Desmin

2

2

High-throughput

0.611

High

664227

TPP2
Tripeptidyl-peptidase 2

2

2

High-throughput

0.596

High

891722

ACTB
Actin, cytoplasmic 1

2

4

High-throughput

0.596

High

929832

ACTG
Actin, cytoplasmic 2

2

4

High-throughput

0.596

High

995515

TNIP1
TNFAIP3-interacting protein 1

2

5

High-throughput

0.596

High

214717

SSNA1
Microtubule nucleation factor SSNA1

2

0

High-throughput

0.571

High

723970

CBS
Cystathionine beta-synthase

2

0

High-throughput

0.571

High

995565

ZBTB9
Zinc finger and BTB domain-containing protein 9

2

8

High-throughput

0.558

High

995524

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

3

High-throughput

0.544

High

995530

C102B
Coiled-coil domain-containing protein 102B

2

1

High-throughput

0.544

High

995535

KCTD9
BTB/POZ domain-containing protein KCTD9

2

2

High-throughput

0.544

High

207797

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

High-throughput

0.515

High

269709

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

3

High-throughput

0.515

High

584937

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

High-throughput

0.515

High

595817

CAN3
Calpain-3

1

1

High-throughput

0.515

High

889234

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.515

High

944754

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.515

High

981559

REL
Proto-oncogene c-Rel

1

4

High-throughput

0.515

High

995509

VAC14
Protein VAC14 homolog

1

2

High-throughput

0.515

High

995510

TRAF2
TNF receptor-associated factor 2

1

8

High-throughput

0.515

High

995511

TRAF1
TNF receptor-associated factor 1

1

5

High-throughput

0.515

High

995520

Q1KLZ0
Actin, cytoplasmic 1

1

4

High-throughput

0.515

High

995522

GRAP1
GRIP1-associated protein 1

1

1

High-throughput

0.515

High

995544

CCD13
Coiled-coil domain-containing protein 13

1

3

High-throughput

0.515

High

995552

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.515

High

995576

LZTS2
Leucine zipper putative tumor suppressor 2

1

6

High-throughput

0.515

High

995582

KR411
Keratin-associated protein 4-11

1

1

High-throughput

0.515

High

995585

TRIM5
Tripartite motif-containing protein 5

1

4

High-throughput

0.515

High

995602

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.515

High

995603

ARMX3
Armadillo repeat-containing X-linked protein 3

1

1

High-throughput

0.515

High

995612

CEP83
Centrosomal protein of 83 kDa

1

2

High-throughput

0.515

High

124398

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.493

High

153653

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.493

High

330073

DRC4
Dynein regulatory complex subunit 4

1

0

High-throughput

0.493

High

979288

UBXN1
UBX domain-containing protein 1

1

0

High-throughput

0.493

High

995519

SMN
Survival motor neuron protein

1

0

High-throughput

0.493

High

995542

HID1
Protein HID1

1

0

High-throughput

0.493

High

995579

HTAI2
Oxidoreductase HTATIP2

1

0

High-throughput

0.493

High

995593

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.493

High

995594

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.493

High

995595

PICK1
PRKCA-binding protein

1

0

High-throughput

0.493

High

995605

IKZF3
Zinc finger protein Aiolos

1

0

High-throughput

0.493

High

897038

ACTZ
Alpha-centractin

1

7

High-throughput

0.479

High

131312

CLD5
Claudin-5

1

2

High-throughput

0.470

High

213117

SNG1
Synaptogyrin-1

1

1

High-throughput

0.470

High

213267

SNG3
Synaptogyrin-3

1

1

High-throughput

0.470

High

258435

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.470

High

723032

OPRM
Mu-type opioid receptor

1

1

High-throughput

0.470

High

734605

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.470

High

738658

TNR3
Tumor necrosis factor receptor superfamily member 3

1

1

High-throughput

0.470

High

828103

CY561
Transmembrane ascorbate-dependent reductase CYB561

1

1

High-throughput

0.470

High

833872

CLK2
Dual specificity protein kinase CLK2

1

2

High-throughput

0.470

High

882100

CLD18
Claudin-18

1

2

High-throughput

0.470

High

940821

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.470

High

995525

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.470

High

995529

ARM12
Armadillo repeat-containing protein 12

1

1

High-throughput

0.470

High

995532

SCAR5
Scavenger receptor class A member 5

1

1

High-throughput

0.470

High

995545

AN36B
Ankyrin repeat domain-containing protein 36B

1

2

High-throughput

0.470

High

995546

RDHE2
Epidermal retinol dehydrogenase 2

1

3

High-throughput

0.470

High

995550

BOLL
Protein boule-like

1

1

High-throughput

0.470

High

995551

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

1

1

High-throughput

0.470

High

995554

PNMA1
Paraneoplastic antigen Ma1

1

2

High-throughput

0.470

High

995561

FGF14
Fibroblast growth factor 14

1

1

High-throughput

0.470

High

995562

TRI63
E3 ubiquitin-protein ligase TRIM63

1

14

High-throughput

0.470

High

995563

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.470

High

995564

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

7

High-throughput

0.470

High

995566

ZBT10
Zinc finger and BTB domain-containing protein 10

1

5

High-throughput

0.470

High

995571

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.470

High

995572

PNMA5
Paraneoplastic antigen-like protein 5

1

2

High-throughput

0.470

High

995574

NACC1
Nucleus accumbens-associated protein 1

1

8

High-throughput

0.470

High

995583

TRI54
Tripartite motif-containing protein 54

1

14

High-throughput

0.470

High

995591

HM20A
High mobility group protein 20A

1

3

High-throughput

0.470

High

995608

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.470

High

995609

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.470

High

995604

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

16

High-throughput

0.457

High

820896

PRC2A
Protein PRRC2A

1

3

High-throughput

0.445

High

995514

MAP7
Ensconsin

1

4

High-throughput

0.445

High

995586

LSG1
Large subunit GTPase 1 homolog

1

1

High-throughput

0.445

High

995597

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.445

High

995601

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.445

High

995606

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

1

High-throughput

0.445

High

995610

WBP11
WW domain-binding protein 11

1

1

High-throughput

0.445

High

995575

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

995526

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.426

High

995533

CENPU
Centromere protein U

1

0

High-throughput

0.426

High

995536

CENPQ
Centromere protein Q

1

0

High-throughput

0.426

High

995537

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.426

High

995541

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.426

High

995581

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.426

High

47155

A0A6Q8KRG2
Golgin subfamily A member 2

1

1

High-throughput

0.417

High

267493

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

2

High-throughput

0.407

High

346622

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.407

High

596744

CD11B
Cyclin-dependent kinase 11B

1

4

High-throughput

0.407

High

995512

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.407

High

995513

ELOA1
Elongin-A

1

1

High-throughput

0.407

High

995528

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

3

High-throughput

0.407

High

995567

RMXL1
RNA binding motif protein, X-linked-like-1

1

3

High-throughput

0.407

High

995577

DIDO1
Death-inducer obliterator 1

1

1

High-throughput

0.407

High

995587

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.407

High

995598

DDX18
ATP-dependent RNA helicase DDX18

1

1

High-throughput

0.407

High

995613

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

2

High-throughput

0.407

High

995538

NECA2
N-terminal EF-hand calcium-binding protein 2

2

0

High-throughput

0.311

High

995543

FUND1
FUN14 domain-containing protein 1

2

0

High-throughput

0.311

High

146486

BHE40
Class E basic helix-loop-helix protein 40

1

0

High-throughput

0.268

Low

152538

PTGES
Prostaglandin E synthase

1

0

High-throughput

0.268

Low

307699

LERL1
Leptin receptor overlapping transcript-like 1

1

0

High-throughput

0.268

Low

873237

EMP1
Epithelial membrane protein 1

1

0

High-throughput

0.268

Low

890927

SYCY2
Syncytin-2

1

0

High-throughput

0.268

Low

945661

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.268

Low

995516

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.268

Low

995517

UT2
Urea transporter 2

1

0

High-throughput

0.268

Low

995518

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.268

Low

995523

NACHO
Novel acetylcholine receptor chaperone

1

0

High-throughput

0.268

Low

995531

LYPD5
Ly6/PLAUR domain-containing protein 5

1

0

High-throughput

0.268

Low

995534

SMIM5
Small integral membrane protein 5

1

0

High-throughput

0.268

Low

995539

CDR2L
Cerebellar degeneration-related protein 2-like

1

0

High-throughput

0.268

Low

995540

TMM17
Transmembrane protein 17

1

0

High-throughput

0.268

Low

995547

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.268

Low

995548

JAGN1
Protein jagunal homolog 1

1

0

High-throughput

0.268

Low

995549

MB213
Protein mab-21-like 3

1

0

High-throughput

0.268

Low

995556

PAQR8
Membrane progestin receptor beta

1

0

High-throughput

0.268

Low

995557

SFT2A
Vesicle transport protein SFT2A

1

0

High-throughput

0.268

Low

995560

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.268

Low

995569

RUSF1
RUS family member 1

1

0

High-throughput

0.268

Low

995570

REEP6
Receptor expression-enhancing protein 6

1

0

High-throughput

0.268

Low

995573

DERL3
Derlin-3

1

0

High-throughput

0.268

Low

995578

TM121
Transmembrane protein 121

1

0

High-throughput

0.268

Low

995580

CA050
Uncharacterized protein C1orf50

1

0

High-throughput

0.268

Low

995584

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

0

High-throughput

0.268

Low

995589

ZBT26
Zinc finger and BTB domain-containing protein 26

1

0

High-throughput

0.268

Low

995590

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.268

Low

995592

S39A2
Zinc transporter ZIP2

1

0

High-throughput

0.268

Low

995596

RPRM
Protein reprimo

1

0

High-throughput

0.268

Low

995599

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.268

Low

995600

ORML1
ORM1-like protein 1

1

0

High-throughput

0.268

Low

995607

COF2
Cofilin-2

1

0

High-throughput

0.268

Low

995521

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.232

Low

995527

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.232

Low

995555

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.232

Low

995559

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

995568

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.232

Low

995588

ESF1
ESF1 homolog

1

0

High-throughput

0.232

Low

995611

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024