Protein: IF2B
Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta)

Gene: IF2B, EIF2S2
Organism: Homo sapiens
Interactions: 194
UniProt ID: P20042

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001731 - formation of translation preinitiation complex
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0002176 - male germ cell proliferation
GO:0002183 - cytoplasmic translational initiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

588849

IF2G
Eukaryotic translation initiation factor 2 subunit 3

9

6

Small-scale

0.971

High

398640

IF2A
Eukaryotic translation initiation factor 2 subunit 1

6

6

Small-scale

0.733

High

275306

CD123
Translation initiation factor eIF2 assembly protein

4

2

Small-scale

0.694

High

588951

ANM7
Protein arginine N-methyltransferase 7

4

2

Small-scale

0.694

High

588876

CSK21
Casein kinase II subunit alpha

3

4

Small-scale

0.692

High

545755

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.691

High

394094

A4
Amyloid-beta precursor protein

3

2

High-throughput

0.660

High

368971

ESR1
Estrogen receptor

3

1

Small-scale

0.641

High

588867

IF5
Eukaryotic translation initiation factor 5

2

3

Small-scale

0.619

High

588898

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.618

High

496277

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.601

High

386076

P53
Cellular tumor antigen p53

2

0

Small-scale

0.588

High

401402

JUN
Transcription factor Jun

2

3

High-throughput

0.588

High

226499

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

345904

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

588839

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.584

High

557598

NCK1
SH2/SH3 adapter protein NCK1

1

1

Small-scale

0.573

High

588875

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.564

High

408552

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

588924

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

2

0

High-throughput

0.547

High

588881

TLE1
Transducin-like enhancer protein 1

1

2

High-throughput

0.541

High

275795

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

4

High-throughput

0.536

High

283388

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

528524

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

588854

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

588855

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

588868

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

5

High-throughput

0.536

High

588870

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

588872

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.536

High

588874

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.536

High

588880

TIE2
Angiopoietin-1 receptor

1

4

High-throughput

0.536

High

588893

RBM39
RNA-binding protein 39

1

2

High-throughput

0.536

High

588920

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.536

High

588935

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

588959

CSN7A
COP9 signalosome complex subunit 7a

1

1

High-throughput

0.536

High

588966

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

588877

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

5

Small-scale

0.534

High

243919

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.533

High

551922

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.533

High

588844

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.533

High

564796

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.527

High

588882

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.518

High

588886

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

588890

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.518

High

588956

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

588973

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

High-throughput

0.518

High

588910

KTN1
Kinectin

1

1

High-throughput

0.515

High

588835

RAB6A
Ras-related protein Rab-6A

1

1

High-throughput

0.515

High

588851

HD
Huntingtin

1

2

High-throughput

0.515

High

447847

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

508818

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

588852

DCC
Netrin receptor DCC

1

0

Small-scale

0.513

High

588857

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

588861

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

588892

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

588901

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

588912

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

588915

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

588923

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.513

High

588931

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

588944

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.513

High

588945

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.513

High

588961

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

588968

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

588971

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.513

High

588972

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

174616

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

588975

5MP1
eIF5-mimic protein 1

1

6

Small-scale

0.501

High

588863

APLP1
Amyloid beta precursor like protein 1

1

2

High-throughput

0.494

High

588896

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

588963

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

351490

NGF
Beta-nerve growth factor

1

0

High-throughput

0.493

High

583933

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.493

High

588853

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.493

High

588865

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

588925

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

588932

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

0

High-throughput

0.493

High

152077

TOR1B
Torsin-1B

1

4

High-throughput

0.489

High

588841

LTK
Leukocyte tyrosine kinase receptor

1

7

High-throughput

0.489

High

148387

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

162400

XPO1
Exportin-1

1

5

High-throughput

0.479

High

230842

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

4

High-throughput

0.479

High

294354

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

322173

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

441878

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

455080

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

507846

FGFR1
Fibroblast growth factor receptor 1

1

9

High-throughput

0.479

High

569167

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

588837

DDX6
Probable ATP-dependent RNA helicase DDX6

1

1

High-throughput

0.479

High

588838

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.479

High

588845

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

588860

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

588862

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

588871

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

588879

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

8

High-throughput

0.479

High

588883

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

588884

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

588885

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

588887

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

588891

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

High-throughput

0.479

High

588894

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

588897

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

588903

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

588904

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

588908

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

588914

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

588917

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

2

High-throughput

0.479

High

588921

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

588926

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

588928

LMTK3
Serine/threonine-protein kinase LMTK3

1

8

High-throughput

0.479

High

588933

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

588942

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

588948

ANLN
Anillin

1

1

High-throughput

0.479

High

588957

HDAC6
Histone deacetylase 6

1

2

High-throughput

0.479

High

588958

KS6B2
Ribosomal protein S6 kinase beta-2

1

2

High-throughput

0.479

High

588960

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

588965

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

588967

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.479

High

588969

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.479

High

588974

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.479

High

233212

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

282523

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.458

High

298142

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

447223

HXB5
Homeobox protein Hox-B5

1

0

High-throughput

0.458

High

588840

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

High-throughput

0.458

High

588843

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

588848

SPB5
Serpin B5

1

0

High-throughput

0.458

High

588850

NAA10
N-alpha-acetyltransferase 10

1

0

Small-scale

0.458

High

588864

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.458

High

588866

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

588873

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

588889

CUL3
Cullin-3

1

0

High-throughput

0.458

High

588895

CUL7
Cullin-7

1

0

High-throughput

0.458

High

588899

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

588902

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

588906

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

588907

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

588909

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

588911

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

588916

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

588918

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

588927

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

588929

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

588930

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

588934

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

588938

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.458

High

588940

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

588946

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

588947

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

588950

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

588962

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

588964

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.458

High

588970

KLH20
Kelch-like protein 20

1

0

High-throughput

0.458

High

373664

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.445

High

100466

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

351932

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

379007

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

384246

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

435532

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.437

High

445821

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

6

High-throughput

0.437

High

572584

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.437

High

588836

FGFR3
Fibroblast growth factor receptor 3

1

8

High-throughput

0.437

High

588842

UFO
Tyrosine-protein kinase receptor UFO

1

5

High-throughput

0.437

High

588846

VGFR2
Vascular endothelial growth factor receptor 2

1

5

High-throughput

0.437

High

588847

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

588869

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

588913

LMTK2
Serine/threonine-protein kinase LMTK2

1

7

High-throughput

0.437

High

588936

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

High-throughput

0.437

High

330849

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

588878

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.426

High

588888

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

588939

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

588859

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

588941

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.282

High

555289

H2AX
Histone H2AX

1

0

High-throughput

0.279

Low

588858

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.279

Low

47197

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

588922

SORL
Sortilin-related receptor

1

0

High-throughput

0.268

Low

169383

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

262368

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

329343

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

388854

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.249

Low

533405

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

588856

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

588900

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

588905

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.249

Low

588937

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

588943

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

588949

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

588952

ANO10
Anoctamin-10

1

0

High-throughput

0.249

Low

588953

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

588954

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

588955

MBD5
Methyl-CpG-binding domain protein 5

1

0

High-throughput

0.249

Low

588919

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024