Protein: TGM2
Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)

Gene: TGM2
Organism: Homo sapiens
Interactions: 155
UniProt ID: P21980

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0003810 - protein-glutamine gamma-glutamyltransferase activity
GO:0005509 - calcium ion binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362813

FINC
Fibronectin

7

2

Small-scale

0.751

High

602796

TGM2
Protein-glutamine gamma-glutamyltransferase 2

2

2

Small-scale

0.744

High

528544

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.650

High

394120

A4
Amyloid-beta precursor protein

3

0

Small-scale

0.636

High

403785

ITB1
Integrin beta-1

2

3

Small-scale

0.595

High

602821

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

2

2

Small-scale

0.595

High

503429

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.586

High

358475

CO1A1
Collagen alpha-1(I) chain

2

4

Small-scale

0.585

High

602836

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

1

High-throughput

0.584

High

602868

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

Small-scale

0.578

High

602800

IKBA
NF-kappa-B inhibitor alpha

2

2

Small-scale

0.571

High

602809

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.564

High

602830

TF65
Transcription factor p65

2

0

Small-scale

0.559

High

602835

SQSTM
Sequestosome-1

2

0

Small-scale

0.559

High

602797

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.537

High

602802

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

Small-scale

0.537

High

602814

PAXI
Paxillin

1

0

Small-scale

0.537

High

434618

TSP1
Thrombospondin-1

1

1

Small-scale

0.536

High

200203

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

1

High-throughput

0.536

High

201213

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

237024

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

1

High-throughput

0.536

High

275489

CAN15
Calpain-15

1

3

High-throughput

0.536

High

409728

CO5A2

1

4

High-throughput

0.536

High

443040

ITA5
Integrin alpha-5

1

2

High-throughput

0.536

High

474921

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.536

High

596151

CO5A1

1

4

High-throughput

0.536

High

602818

RBM25
RNA-binding protein 25

1

1

High-throughput

0.536

High

602822

BLK
Tyrosine-protein kinase Blk

1

1

High-throughput

0.536

High

602873

WNK1
Serine/threonine-protein kinase WNK1

1

1

High-throughput

0.536

High

602886

MCM8
DNA helicase MCM8

1

4

High-throughput

0.536

High

602880

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.518

High

521721

CADH1
Cadherin-1

1

1

Small-scale

0.515

High

128438

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.515

High

231451

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.515

High

313686

SOX14
Transcription factor SOX-14

1

1

High-throughput

0.515

High

388226

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.515

High

602820

DYN2
Dynamin-2

1

3

High-throughput

0.515

High

602831

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.515

High

602857

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

602838

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.513

High

602839

MVP
Major vault protein

1

0

High-throughput

0.513

High

602840

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.513

High

602842

SF3B4
Splicing factor 3B subunit 4

1

0

High-throughput

0.513

High

602844

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

602845

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

602848

TIGD5
Tigger transposable element-derived protein 5

1

0

High-throughput

0.513

High

602850

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

0

High-throughput

0.513

High

602851

DEN4C
DENN domain-containing protein 4C

1

0

High-throughput

0.513

High

602853

BORA
Protein aurora borealis

1

0

High-throughput

0.513

High

602864

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.513

High

602872

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

602877

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

602878

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.513

High

602882

E2AK4
eIF-2-alpha kinase GCN2

1

0

High-throughput

0.513

High

602885

ENOPH
Enolase-phosphatase E1

1

0

High-throughput

0.513

High

449538

HMGB1
High mobility group protein B1

1

3

Small-scale

0.508

High

602828

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.508

High

602834

PAK1
Serine/threonine-protein kinase PAK 1

1

1

High-throughput

0.508

High

602843

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.508

High

358653

CO4A1

1

4

Small-scale

0.501

High

419156

ITAV
Integrin alpha-V

1

2

Small-scale

0.501

High

517902

COBA1

1

4

Small-scale

0.501

High

517923

CO6A1

1

3

Small-scale

0.501

High

602803

LYOX
Protein-lysine 6-oxidase

1

3

Small-scale

0.501

High

602808

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

4

Small-scale

0.501

High

602824

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.493

High

151967

TOR1A
Torsin-1A

1

0

High-throughput

0.493

High

281543

WFS1
Wolframin

1

0

High-throughput

0.493

High

363565

TTHY
Transthyretin

1

0

High-throughput

0.493

High

602805

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.493

High

602810

HD
Huntingtin

1

0

High-throughput

0.493

High

602826

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

602837

SEPT6
Septin-6

1

0

High-throughput

0.493

High

602849

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.493

High

602861

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

602847

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.489

High

602855

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

1

High-throughput

0.489

High

602863

GT251
Procollagen galactosyltransferase 1

1

1

High-throughput

0.489

High

602832

AKP13
A-kinase anchor protein 13

1

0

Small-scale

0.484

High

166883

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

1

High-throughput

0.481

High

344439

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.481

High

344640

CO3
Complement C3

1

1

High-throughput

0.481

High

586566

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.481

High

602823

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

3

High-throughput

0.481

High

602867

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

2

High-throughput

0.481

High

602798

LAMA1
Laminin subunit alpha-1

1

0

Small-scale

0.480

High

602819

MMP14
Matrix metalloproteinase-14

1

0

Small-scale

0.480

High

602841

PCOC1
Procollagen C-endopeptidase enhancer 1

1

0

Small-scale

0.480

High

226518

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

297034

TOM70
Mitochondrial import receptor subunit TOM70

1

2

Small-scale

0.479

High

345924

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

373682

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

386089

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

397271

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.479

High

448290

GSTP1
Glutathione S-transferase P

1

1

Small-scale

0.479

High

475334

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.479

High

501676

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

518251

ADT3
ADP/ATP translocase 3

1

2

Small-scale

0.479

High

522775

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.479

High

556412

ITB4
Integrin beta-4

1

3

Small-scale

0.479

High

602801

ITA3
Integrin alpha-3

1

2

Small-scale

0.479

High

602806

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

602807

GRP75
Stress-70 protein, mitochondrial

1

6

Small-scale

0.479

High

602811

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.479

High

602812

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

602817

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

602854

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

602875

ANLN
Anillin

1

1

High-throughput

0.479

High

602883

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

602887

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

103700

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

602879

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

2

High-throughput

0.470

High

602866

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.464

High

315238

ABCA1
Phospholipid-transporting ATPase ABCA1

1

0

High-throughput

0.460

High

341186

HPT
Haptoglobin

1

0

High-throughput

0.460

High

579242

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.460

High

602804

GRN
Progranulin

1

0

High-throughput

0.460

High

602813

GLR
Glucagon receptor

1

0

High-throughput

0.460

High

602816

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.460

High

602825

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

0

High-throughput

0.460

High

602827

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.460

High

602833

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

0

High-throughput

0.460

High

602874

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

0

Small-scale

0.460

High

602884

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

602888

CERT
Ceramide transfer protein

1

0

High-throughput

0.460

High

134834

IMA3
Importin subunit alpha-3

1

0

Small-scale

0.458

High

205041

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

233219

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

329355

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

414167

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

441092

CY1
Cytochrome c1, heme protein, mitochondrial

1

0

Small-scale

0.458

High

444314

K1C19
Keratin, type I cytoskeletal 19

1

0

Small-scale

0.458

High

537560

PA2GA
Phospholipase A2, membrane associated

1

0

Small-scale

0.458

High

566920

CXA1
Gap junction alpha-1 protein

1

0

Small-scale

0.458

High

590621

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

596716

CD11B
Cyclin-dependent kinase 11B

1

0

High-throughput

0.458

High

602799

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

Small-scale

0.458

High

602815

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

602829

VIGLN
Vigilin

1

0

High-throughput

0.458

High

602846

H31T
Histone H3.1t

1

0

Small-scale

0.458

High

602860

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

Small-scale

0.458

High

602862

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

602869

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

602870

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.458

High

602876

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

602856

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

548859

NDKA
Nucleoside diphosphate kinase A

1

0

Small-scale

0.426

High

602852

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.279

Low

47198

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

602858

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

602871

LACRT
Extracellular glycoprotein lacritin

1

0

Small-scale

0.261

Low

602865

T176A
Transmembrane protein 176A

1

0

High-throughput

0.251

Low

602881

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.251

Low

602859

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024