Protein: KAD2
Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]

Gene: KAD2, AK2
Organism: Homo sapiens
Interactions: 122
UniProt ID: P54819

Gene Ontology (top 5):
GO:0004017 - adenylate kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

325106

AIFM1
Apoptosis-inducing factor 1, mitochondrial

5

4

High-throughput

0.714

High

873030

CUL3
Cullin-3

2

1

High-throughput

0.611

High

873040

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.571

High

873077

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

153108

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

5

High-throughput

0.536

High

157309

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

4

High-throughput

0.536

High

270389

KS6A5
Ribosomal protein S6 kinase alpha-5

1

3

High-throughput

0.536

High

440434

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.536

High

452696

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

515388

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.536

High

873027

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.536

High

873032

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

2

High-throughput

0.536

High

873036

PDK4
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

873042

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.536

High

873054

STK35
Serine/threonine-protein kinase 35

1

4

High-throughput

0.536

High

873055

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

873062

AURKB
Aurora kinase B

1

3

High-throughput

0.536

High

873065

TSSK3
Testis-specific serine/threonine-protein kinase 3

1

3

High-throughput

0.536

High

873070

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

4

High-throughput

0.536

High

873080

LATS2
Serine/threonine-protein kinase LATS2

1

2

High-throughput

0.536

High

873081

NRBP2
Nuclear receptor-binding protein 2

1

4

High-throughput

0.536

High

496641

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.515

High

557446

PECA1
Platelet endothelial cell adhesion molecule

1

1

High-throughput

0.515

High

568598

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.515

High

868391

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

201281

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

336427

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

848335

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

873038

PKDCC
Extracellular tyrosine-protein kinase PKDCC

1

0

High-throughput

0.513

High

873049

CDK20
Cyclin-dependent kinase 20

1

0

High-throughput

0.513

High

873057

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.513

High

873083

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.513

High

317552

ADCY5
Adenylate cyclase type 5

1

0

High-throughput

0.493

High

873037

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.493

High

443423

VIME
Vimentin

1

0

High-throughput

0.493

High

739931

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

538754

HXB1
Homeobox protein Hox-B1

1

1

High-throughput

0.489

High

873088

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.489

High

179397

MRP5
ATP-binding cassette sub-family C member 5

1

1

High-throughput

0.481

High

309790

MRP6
ATP-binding cassette sub-family C member 6

1

1

High-throughput

0.481

High

873072

TRI54
Tripartite motif-containing protein 54

1

8

High-throughput

0.481

High

166684

CE290
Centrosomal protein of 290 kDa

1

1

High-throughput

0.479

High

203896

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

373935

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

384559

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

569459

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

616773

JAK1
Tyrosine-protein kinase JAK1

1

1

High-throughput

0.479

High

617488

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.479

High

790720

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

5

High-throughput

0.479

High

790919

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

4

High-throughput

0.479

High

790961

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

6

High-throughput

0.479

High

835292

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

835608

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

873022

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

7

High-throughput

0.479

High

873025

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

873029

PAK2
Serine/threonine-protein kinase PAK 2

1

3

High-throughput

0.479

High

873033

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

873041

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

873044

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

873046

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

873058

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

873059

OPTN
Optineurin

1

1

High-throughput

0.479

High

873064

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

873074

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

873079

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

873082

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.479

High

873084

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

873085

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.479

High

873087

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

380943

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

117376

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

274516

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

276806

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

324299

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

607616

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

779091

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

873023

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

873024

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

873026

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

873031

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

873035

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

873048

MTMRD
Myotubularin-related protein 13

1

0

High-throughput

0.458

High

873050

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

873056

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

873060

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

873063

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

873067

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

873068

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

873069

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

873073

ARP6
Actin-related protein 6

1

0

High-throughput

0.458

High

873075

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

873076

Q9H4D1
Protein kinase

1

0

High-throughput

0.458

High

517153

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.457

High

239540

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.437

High

329538

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

641685

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

High-throughput

0.437

High

720066

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

873034

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.437

High

873043

BCOR
BCL-6 corepressor

1

2

High-throughput

0.437

High

873053

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.437

High

873066

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

581574

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

873051

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

Small-scale

0.426

High

873061

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

401698

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

873039

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.279

Low

873071

UBP26
Ubiquitin carboxyl-terminal hydrolase 26

1

0

High-throughput

0.269

Low

47205

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

834954

PSN2
Presenilin-2

1

0

High-throughput

0.268

Low

839557

SERPH
Serpin H1

1

0

High-throughput

0.268

Low

205218

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

351734

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

505592

EPB41
Protein 4.1

1

0

High-throughput

0.249

Low

552333

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

650778

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

781331

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

873028

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.249

Low

873045

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

873047

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

873052

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

873078

PLRKT
Plasminogen receptor

1

0

High-throughput

0.249

Low

873086

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024