Protein: ERCC8
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)

Gene: ERCC8
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q13216

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000109 - nucleotide-excision repair complex
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1028001

DDB1
DNA damage-binding protein 1

12

20

Small-scale

0.975

High

1027992

ERCC8
DNA excision repair protein ERCC-8

2

17

Small-scale

0.768

High

976442

ERCC6
DNA excision repair protein ERCC-6

13

20

Small-scale

0.760

High

1027994

CUL4A
Cullin-4A

13

20

Small-scale

0.757

High

1027995

CUL4B
Cullin-4B

7

20

Small-scale

0.750

High

1028008

CSN6
COP9 signalosome complex subunit 6

6

2

Small-scale

0.729

High

1028037

CSN3
COP9 signalosome complex subunit 3

6

7

Small-scale

0.728

High

1028014

CSN5
COP9 signalosome complex subunit 5

5

7

Small-scale

0.712

High

1028002

UVSSA
UV-stimulated scaffold protein A

6

0

Small-scale

0.692

High

215343

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

19

High-throughput

0.691

High

624883

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

5

Small-scale

0.680

High

1028022

CSN4
COP9 signalosome complex subunit 4

4

3

Small-scale

0.676

High

1028034

CSN7A
COP9 signalosome complex subunit 7a

4

3

Small-scale

0.676

High

1028029

PFD4
Prefoldin subunit 4

3

4

Small-scale

0.667

High

1028024

SKI8
Superkiller complex protein 8

1

18

High-throughput

0.665

High

1024152

CSN1
COP9 signalosome complex subunit 1

3

8

Small-scale

0.656

High

921242

RBX1
E3 ubiquitin-protein ligase RBX1

3

5

Small-scale

0.646

High

897238

CSN2
COP9 signalosome complex subunit 2

3

9

Small-scale

0.640

High

1028023

DDA1
DET1- and DDB1-associated protein 1

3

4

Small-scale

0.640

High

1028026

CSN7B
COP9 signalosome complex subunit 7b

3

3

Small-scale

0.640

High

153658

ANM5
Protein arginine N-methyltransferase 5

1

6

Small-scale

0.618

High

896061

UBC12
NEDD8-conjugating enzyme Ubc12

1

8

High-throughput

0.618

High

907884

RS16
Small ribosomal subunit protein uS9

1

9

High-throughput

0.618

High

929435

RACK1
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.618

High

1028000

SF3B3
Splicing factor 3B subunit 3

1

20

Small-scale

0.618

High

1028003

DCAF6
DDB1- and CUL4-associated factor 6

1

18

High-throughput

0.618

High

1028005

PRP8
Pre-mRNA-processing-splicing factor 8

1

6

Small-scale

0.618

High

1028009

COP1
E3 ubiquitin-protein ligase COP1

1

16

High-throughput

0.618

High

1028013

DDB2
DNA damage-binding protein 2

1

17

Small-scale

0.618

High

1028019

CSN8
COP9 signalosome complex subunit 8

3

0

Small-scale

0.613

High

943212

TCPB
T-complex protein 1 subunit beta

3

20

Small-scale

0.599

High

231510

KIF1B
Kinesin-like protein KIF1B

1

8

High-throughput

0.594

High

573241

TCPA
T-complex protein 1 subunit alpha

3

20

Small-scale

0.585

High

826641

TCPG
T-complex protein 1 subunit gamma

3

20

Small-scale

0.585

High

598096

FLNA
Filamin-A

2

15

Small-scale

0.584

High

842851

TCPQ
T-complex protein 1 subunit theta

2

20

Small-scale

0.584

High

1028018

PFD5
Prefoldin subunit 5

2

7

Small-scale

0.584

High

1028036

PFD2
Prefoldin subunit 2

2

4

Small-scale

0.584

High

1027996

TF2H2
General transcription factor IIH subunit 2

1

1

Small-scale

0.578

High

1028028

SYF1
Pre-mRNA-splicing factor SYF1

1

20

Small-scale

0.578

High

1028004

STXB5
Syntaxin-binding protein 5

1

15

High-throughput

0.553

High

1028015

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1028031

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

High-throughput

0.536

High

171615

PFD6
Prefoldin subunit 6

2

7

Small-scale

0.533

High

770812

TCPZ
T-complex protein 1 subunit zeta

2

20

Small-scale

0.533

High

821190

TCPE
T-complex protein 1 subunit epsilon

2

20

Small-scale

0.533

High

166506

NACAD
NAC-alpha domain-containing protein 1

1

20

High-throughput

0.515

High

278074

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.515

High

868470

ATX1
Ataxin-1

1

6

High-throughput

0.515

High

1028011

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

931615

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.508

High

203925

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

1028016

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.493

High

1028025

FBX44
F-box only protein 44

1

2

High-throughput

0.489

High

1027993

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

3

High-throughput

0.481

High

118727

AIP
AH receptor-interacting protein

1

12

High-throughput

0.479

High

128547

DNM1L
Dynamin-1-like protein

1

7

Small-scale

0.479

High

136014

ACACB
Acetyl-CoA carboxylase 2

1

19

High-throughput

0.479

High

272119

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

Small-scale

0.479

High

299364

UBXN7
UBX domain-containing protein 7

1

2

Small-scale

0.479

High

381184

TBB4A
Tubulin beta-4A chain

1

19

Small-scale

0.479

High

386655

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

396729

S10A8
Protein S100-A8

1

4

Small-scale

0.479

High

416417

S10A9
Protein S100-A9

1

4

Small-scale

0.479

High

426632

H10
Histone H1.0

1

2

Small-scale

0.479

High

445387

RSSA
Small ribosomal subunit protein uS2

1

2

Small-scale

0.479

High

499726

CH60
60 kDa heat shock protein, mitochondrial

1

15

Small-scale

0.479

High

504013

HSP7C
Heat shock cognate 71 kDa protein

1

14

Small-scale

0.479

High

508975

TOP2A
DNA topoisomerase 2-alpha

1

8

High-throughput

0.479

High

517233

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.479

High

551690

DESP
Desmoplakin

1

20

High-throughput

0.479

High

563597

ZNF24
Zinc finger protein 24

1

3

Small-scale

0.479

High

566380

KPCA
Protein kinase C alpha type

1

8

Small-scale

0.479

High

579203

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

11

Small-scale

0.479

High

582266

NUCL
Nucleolin

1

5

Small-scale

0.479

High

656708

PSB5
Proteasome subunit beta type-5

1

6

Small-scale

0.479

High

658354

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.479

High

681425

DNJA1
DnaJ homolog subfamily A member 1

1

13

Small-scale

0.479

High

807345

RS10
Small ribosomal subunit protein eS10

1

6

Small-scale

0.479

High

809291

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

Small-scale

0.479

High

843181

TCPD
T-complex protein 1 subunit delta

1

20

Small-scale

0.479

High

871555

HSP72
Heat shock-related 70 kDa protein 2

1

12

Small-scale

0.479

High

874888

TERA
Transitional endoplasmic reticulum ATPase

1

7

Small-scale

0.479

High

882907

RBM11
Splicing regulator RBM11

1

8

High-throughput

0.479

High

901664

PFD3
Prefoldin subunit 3

1

6

High-throughput

0.479

High

919957

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.479

High

920764

RS28
Small ribosomal subunit protein eS28

1

1

Small-scale

0.479

High

933783

TBB4B
Tubulin beta-4B chain

1

19

Small-scale

0.479

High

962759

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.479

High

964915

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

967861

PO5F1
POU domain, class 5, transcription factor 1

1

5

High-throughput

0.479

High

970765

DSG1
Desmoglein-1

1

7

High-throughput

0.479

High

981227

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.479

High

994143

DHX9
ATP-dependent RNA helicase A

1

12

Small-scale

0.479

High

998643

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1027997

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

19

Small-scale

0.479

High

1027998

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

20

Small-scale

0.479

High

1027999

MVP
Major vault protein

1

1

Small-scale

0.479

High

1028006

BCOR
BCL-6 corepressor

1

11

High-throughput

0.479

High

1028010

HDAC7
Histone deacetylase 7

1

20

Small-scale

0.479

High

1028017

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

Small-scale

0.479

High

1028021

PCGF1
Polycomb group RING finger protein 1

1

19

High-throughput

0.479

High

1028027

NANOG
Homeobox protein NANOG

1

10

High-throughput

0.479

High

1028035

DNJB4
DnaJ homolog subfamily B member 4

1

12

Small-scale

0.479

High

1028038

RUVB2
RuvB-like 2

1

6

Small-scale

0.479

High

1028039

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

Small-scale

0.479

High

1028040

NUDC
Nuclear migration protein nudC

1

17

High-throughput

0.479

High

47220

A0A6Q8PF08
Peripheral myelin protein 22

1

1

High-throughput

0.470

High

535382

GFAP
Glial fibrillary acidic protein

1

8

High-throughput

0.470

High

893341

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.470

High

181955

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.458

High

396930

HMGN1
Non-histone chromosomal protein HMG-14

1

0

Small-scale

0.458

High

1028007

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1028030

F217B
Protein FAM217B

1

0

Small-scale

0.458

High

1028033

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

Small-scale

0.458

High

243386

DNJA2
DnaJ homolog subfamily A member 2

1

13

Small-scale

0.437

High

245970

PFD1
Prefoldin subunit 1

1

4

Small-scale

0.437

High

323729

BAG2
BAG family molecular chaperone regulator 2

1

2

Small-scale

0.437

High

612009

HEMH
Ferrochelatase, mitochondrial

1

1

Small-scale

0.437

High

1028020

TCPH
T-complex protein 1 subunit eta

1

20

Small-scale

0.437

High

556615

CBR1
Carbonyl reductase [NADPH] 1

1

2

High-throughput

0.417

High

508498

TOP1
DNA topoisomerase 1

1

4

Small-scale

0.408

High

1028012

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

1028032

IFNK
Interferon kappa

1

0

Small-scale

0.249

Low

159480

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024