Protein: TDG
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG)

Gene: TDG
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q13569

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0003676 - nucleic acid binding
GO:0003677 - DNA binding
GO:0003684 - damaged DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

928090

SUMO1
Small ubiquitin-related modifier 1

7

2

Small-scale

0.967

High

902568

SUMO2
Small ubiquitin-related modifier 2

3

2

Small-scale

0.854

High

1039489

CBP
CREB-binding protein

6

1

Small-scale

0.735

High

879111

SUMO3
Small ubiquitin-related modifier 3

1

2

Small-scale

0.680

High

930201

UBC9
SUMO-conjugating enzyme UBC9

3

1

Small-scale

0.655

High

175872

P73
Tumor protein p73

2

2

Small-scale

0.633

High

386688

P53
Cellular tumor antigen p53

2

2

Small-scale

0.633

High

1039481

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.614

High

487965

RARA
Retinoic acid receptor alpha

2

3

Small-scale

0.595

High

1039493

P63
Tumor protein 63

1

2

Small-scale

0.573

High

346722

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.571

High

369552

ESR1
Estrogen receptor

1

5

Small-scale

0.561

High

1039495

DNM3B
DNA

1

1

Small-scale

0.561

High

776675

STAT3
Signal transducer and activator of transcription 3

2

0

High-throughput

0.551

High

802591

CRK
Adapter molecule crk

2

0

High-throughput

0.551

High

517241

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.537

High

668661

PML
Protein PML

1

0

Small-scale

0.537

High

1039491

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

1039494

DTL
Denticleless protein homolog

1

0

Small-scale

0.537

High

1039492

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.536

High

622946

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

Small-scale

0.515

High

967027

XPC
DNA repair protein complementing XP-C cells

1

0

Small-scale

0.504

High

377308

GCR
Glucocorticoid receptor

1

6

Small-scale

0.501

High

414501

PRGR
Progesterone receptor

1

5

Small-scale

0.501

High

487411

ANDR
Androgen receptor

1

5

Small-scale

0.501

High

500417

THA
Thyroid hormone receptor alpha

1

3

Small-scale

0.501

High

509946

VDR
Vitamin D3 receptor

1

4

Small-scale

0.501

High

587165

RXRA
Retinoic acid receptor RXR-alpha

1

2

Small-scale

0.501

High

998672

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.501

High

1039483

NCOA1
Nuclear receptor coactivator 1

1

0

Small-scale

0.493

High

231513

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

281618

WFS1
Wolframin

1

0

High-throughput

0.493

High

388422

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

422172

NFL
Neurofilament light polypeptide

1

0

High-throughput

0.493

High

660484

GRN
Progranulin

1

0

High-throughput

0.493

High

742281

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

893343

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

1039490

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1039496

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

521353

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

1035423

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.486

High

1039485

SETX
Probable helicase senataxin

1

0

Small-scale

0.486

High

566757

JUNB
Transcription factor JunB

1

1

High-throughput

0.481

High

238269

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.480

High

245901

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.480

High

165849

KDM6B
Lysine-specific demethylase 6B

1

1

Small-scale

0.479

High

1039484

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

1

High-throughput

0.479

High

1039497

DNM3A
DNA

1

1

Small-scale

0.479

High

310400

EPM2A
Laforin

1

0

Small-scale

0.460

High

594248

MX1
Interferon-induced GTP-binding protein Mx1

1

0

Small-scale

0.460

High

988070

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.460

High

1033634

IKZF1
DNA-binding protein Ikaros

1

0

High-throughput

0.460

High

1039486

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

Small-scale

0.460

High

1039487

SERB1
SERPINE1 mRNA-binding protein 1

1

0

Small-scale

0.460

High

176598

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

551141

ITF2
Transcription factor 4

1

0

Small-scale

0.458

High

579701

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

872264

RD23B
UV excision repair protein RAD23 homolog B

1

0

Small-scale

0.458

High

940871

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.458

High

1039482

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.438

High

1039488

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.438

High

47221

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

363594

TTHY
Transthyretin

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024