Protein: SPRE2
Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)

Gene: SPRE2, SPRED2
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q7Z698

Gene Ontology (top 5):
GO:0005173 - stem cell factor receptor binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0010719 - negative regulation of epithelial to mesenchymal transition
GO:0010801 - negative regulation of peptidyl-threonine phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1191413

SPG21
Maspardin

4

1

High-throughput

0.698

High

1036696

SQSTM
Sequestosome-1

3

3

Small-scale

0.670

High

1191392

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

15

High-throughput

0.665

High

1191393

DPP9
Dipeptidyl peptidase 9

2

1

High-throughput

0.628

High

1056067

NBR1
Next to BRCA1 gene 1 protein

2

2

Small-scale

0.624

High

850676

KS6A3
Ribosomal protein S6 kinase alpha-3

2

7

High-throughput

0.621

High

670358

AQP1
Aquaporin-1

2

3

High-throughput

0.606

High

887387

KR122
Keratin-associated protein 12-2

2

20

High-throughput

0.606

High

906770

NCS1
Neuronal calcium sensor 1

2

8

High-throughput

0.606

High

917030

VISL1
Visinin-like protein 1

2

8

High-throughput

0.606

High

1191406

TSNAX
Translin-associated protein X

2

1

High-throughput

0.606

High

1191414

KCIP1
Kv channel-interacting protein 1

2

8

High-throughput

0.606

High

1191416

KS6A6
Ribosomal protein S6 kinase alpha-6

2

7

High-throughput

0.606

High

929167

GBG5

2

0

High-throughput

0.602

High

1191396

ZDH17
Palmitoyltransferase ZDHHC17

2

14

High-throughput

0.591

High

350297

RASK
GTPase KRas

2

9

High-throughput

0.584

High

814481

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.580

High

1191415

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

2

1

High-throughput

0.574

High

150451

LCE2B
Late cornified envelope protein 2B

2

1

High-throughput

0.553

High

549189

ZN250
Zinc finger protein 250

2

2

High-throughput

0.553

High

568462

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

1

High-throughput

0.553

High

1134354

KPRP
Keratinocyte proline-rich protein

2

2

High-throughput

0.553

High

1134491

LCE1C
Late cornified envelope protein 1C

2

7

High-throughput

0.553

High

1136398

LCE5A
Late cornified envelope protein 5A

2

1

High-throughput

0.553

High

1191394

ZN575
Zinc finger protein 575

2

11

High-throughput

0.553

High

1191399

ZN417
Zinc finger protein 417

2

9

High-throughput

0.553

High

1191403

ZN837
Zinc finger protein 837

2

7

High-throughput

0.553

High

1191404

ZN414
Zinc finger protein 414

2

2

High-throughput

0.553

High

1191407

MDFI
MyoD family inhibitor

2

2

High-throughput

0.553

High

1191410

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

0

Small-scale

0.537

High

119723

AP4M1
AP-4 complex subunit mu-1

1

1

High-throughput

0.536

High

1071654

KS6A2
Ribosomal protein S6 kinase alpha-2

1

7

High-throughput

0.536

High

1191412

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

1

High-throughput

0.536

High

360095

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.515

High

535448

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.515

High

609383

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.515

High

657948

CLAT
Choline O-acetyltransferase

1

2

High-throughput

0.515

High

660593

GRN
Progranulin

1

4

High-throughput

0.515

High

667703

NOS3
Nitric oxide synthase 3

1

1

High-throughput

0.515

High

791710

HD
Huntingtin

1

3

High-throughput

0.515

High

840745

DYN2
Dynamin-2

1

3

High-throughput

0.515

High

893393

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.515

High

1121063

GLE1
mRNA export factor GLE1

1

1

High-throughput

0.515

High

1191408

KRA24
Keratin-associated protein 2-4

1

20

High-throughput

0.515

High

646213

STOM
Stomatin

1

0

High-throughput

0.513

High

837622

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

High-throughput

0.513

High

1191398

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.513

High

1191402

F162A
Protein FAM162A

1

0

High-throughput

0.513

High

1191409

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

1

0

High-throughput

0.513

High

1191411

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.513

High

1043917

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.494

High

653640

CALR
Calreticulin

1

0

High-throughput

0.493

High

739176

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

296458

ACL6B
Actin-like protein 6B

1

10

High-throughput

0.489

High

620674

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

2

High-throughput

0.489

High

1191395

ZDH13
Palmitoyltransferase ZDHHC13

1

14

High-throughput

0.489

High

473309

KRA23
Keratin-associated protein 2-3

1

20

High-throughput

0.481

High

793370

MUC18
Cell surface glycoprotein MUC18

1

9

High-throughput

0.479

High

915793

RHOB
Rho-related GTP-binding protein RhoB

1

12

High-throughput

0.479

High

1075276

TESK1
Dual specificity testis-specific protein kinase 1

1

6

Small-scale

0.479

High

1191397

FBXW8
F-box/WD repeat-containing protein 8

1

1

High-throughput

0.479

High

47253

A0A6Q8PF08
Peripheral myelin protein 22

1

2

High-throughput

0.470

High

103774

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

231590

KIF1B
Kinesin-like protein KIF1B

1

7

High-throughput

0.470

High

281717

WFS1
Wolframin

1

3

High-throughput

0.470

High

584005

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.470

High

1191400

NEK7
Serine/threonine-protein kinase Nek7

1

5

High-throughput

0.470

High

1191401

APBB2
Amyloid beta precursor protein binding family B member 2

1

4

High-throughput

0.470

High

1191405

MY15B
Unconventional myosin-XVB

1

2

High-throughput

0.470

High

1191417

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

427096

CATD
Cathepsin D

1

3

Small-scale

0.457

High

500829

CLUS
Clusterin

1

1

High-throughput

0.457

High

610447

CBL
E3 ubiquitin-protein ligase CBL

1

10

Small-scale

0.445

High

328883

TOP3B
DNA topoisomerase 3-beta-1

2

0

High-throughput

0.327

High

1130076

RBM48
RNA-binding protein 48

2

0

High-throughput

0.316

High

62951

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.279

Low

1086636

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024