Protein: RN138
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)

Gene: RN138, RNF138
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q8WVD3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus
GO:0010792 - DNA double-strand break processing involved in repair via single-strand annealing
GO:0016055 - Wnt signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

896344

UBE2K
Ubiquitin-conjugating enzyme E2 K

10

20

Small-scale

0.980

High

919801

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.698

High

1232886

LNX2
Ligand of Numb protein X 2

1

19

High-throughput

0.698

High

1261285

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1261313

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

262521

TULP3
Tubby-related protein 3

3

1

High-throughput

0.667

High

1082599

MK14
Mitogen-activated protein kinase 14

3

3

High-throughput

0.667

High

1261291

NP1L5
Nucleosome assembly protein 1-like 5

3

2

High-throughput

0.667

High

1261301

TRPV5
Transient receptor potential cation channel subfamily V member 5

3

2

High-throughput

0.667

High

228179

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.665

High

476111

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

935031

H31
Histone H3.1

1

15

Small-scale

0.647

High

274769

RA51D
DNA repair protein RAD51 homolog 4

2

1

Small-scale

0.643

High

883726

WDR4
tRNA

2

12

High-throughput

0.628

High

1157347

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

8

High-throughput

0.628

High

1261310

LEF1
Lymphoid enhancer-binding factor 1

2

14

Small-scale

0.624

High

896161

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.618

High

1119570

MIDN
Midnolin

1

1

High-throughput

0.618

High

1183799

5MP2
eIF5-mimic protein 2

3

2

High-throughput

0.609

High

1261289

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

3

High-throughput

0.606

High

1261295

CSN8
COP9 signalosome complex subunit 8

2

0

High-throughput

0.602

High

584437

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

20

High-throughput

0.574

High

1261302

TF7L2
Transcription factor 7-like 2

1

13

Small-scale

0.561

High

328024

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

6

High-throughput

0.553

High

884390

PCBP4
Poly(rC)-binding protein 4

1

15

High-throughput

0.541

High

1261292

QKI
KH domain-containing RNA-binding protein QKI

1

8

High-throughput

0.541

High

1261298

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

19

High-throughput

0.541

High

617615

CRCM
Colorectal mutant cancer protein

1

8

High-throughput

0.536

High

672707

CD6
T-cell differentiation antigen CD6

1

6

High-throughput

0.536

High

970721

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

12

High-throughput

0.536

High

1184919

CSN6
COP9 signalosome complex subunit 6

1

5

High-throughput

0.536

High

1261284

CSN5
COP9 signalosome complex subunit 5

1

11

High-throughput

0.536

High

1261303

DPOE3
DNA polymerase epsilon subunit 3

1

1

High-throughput

0.536

High

1261305

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

7

High-throughput

0.536

High

1261308

RBX2
RING-box protein 2

1

2

High-throughput

0.536

High

1261312

PHF8
Histone lysine demethylase PHF8

1

7

High-throughput

0.536

High

1261315

ARI1
E3 ubiquitin-protein ligase ARIH1

1

16

High-throughput

0.536

High

72148

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1083681

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.518

High

204003

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.515

High

360207

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.515

High

429093

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.515

High

719561

MERL
Merlin

1

6

High-throughput

0.515

High

742427

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

1025868

TADBP
TAR DNA-binding protein 43

1

20

High-throughput

0.515

High

1191491

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

8

High-throughput

0.515

High

1261314

RNF11
RING finger protein 11

1

3

High-throughput

0.515

High

1238565

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

1261288

CPNE2
Copine-2

1

0

High-throughput

0.513

High

387188

P53
Cellular tumor antigen p53

1

9

Small-scale

0.501

High

217042

PRIC3
Prickle planar cell polarity protein 3

1

13

High-throughput

0.489

High

253130

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.489

High

280057

MPDZ
Multiple PDZ domain protein

1

19

High-throughput

0.489

High

1219667

RHG12
Rho GTPase-activating protein 12

1

1

High-throughput

0.489

High

1244883

GP156
Probable G-protein coupled receptor 156

1

1

High-throughput

0.489

High

1261293

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

161416

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

13

High-throughput

0.479

High

163057

XPO1
Exportin-1

1

10

High-throughput

0.479

High

168956

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

244699

BRD4
Bromodomain-containing protein 4

1

11

High-throughput

0.479

High

299432

UBXN7
UBX domain-containing protein 7

1

5

High-throughput

0.479

High

303747

ZO3
Tight junction protein ZO-3

1

10

High-throughput

0.479

High

391439

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

High-throughput

0.479

High

433918

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.479

High

616426

RS3
Small ribosomal subunit protein uS3

1

4

Small-scale

0.479

High

717236

CTNB1
Catenin beta-1

1

11

High-throughput

0.479

High

725985

ADDA
Alpha-adducin

1

2

High-throughput

0.479

High

779807

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

832142

PSB2
Proteasome subunit beta type-2

1

7

Small-scale

0.479

High

932797

EF1A1
Elongation factor 1-alpha 1

1

8

Small-scale

0.479

High

997828

RBBP4
Histone-binding protein RBBP4

1

14

Small-scale

0.479

High

1038572

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

1042147

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1261297

RBM4
RNA-binding protein 4

1

15

Small-scale

0.479

High

1261300

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1261304

LYAR
Cell growth-regulating nucleolar protein

1

2

Small-scale

0.479

High

1261309

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1261311

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

1

High-throughput

0.479

High

1261316

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

9

High-throughput

0.479

High

103810

G5E9A7
DM1 locus, WD repeat containing

1

16

High-throughput

0.470

High

231651

KIF1B
Kinesin-like protein KIF1B

1

8

High-throughput

0.470

High

349529

RASH
GTPase HRas

1

9

High-throughput

0.470

High

609447

FGFR3
Fibroblast growth factor receptor 3

1

10

High-throughput

0.470

High

1261282

JPH3
Junctophilin-3

1

1

High-throughput

0.470

High

786040

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

1261296

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

395325

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.457

High

275453

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

1222483

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.445

High

534206

CD59
CD59 glycoprotein

1

1

High-throughput

0.437

High

615798

GCSP
Glycine dehydrogenase

1

2

High-throughput

0.437

High

647139

1433T
14-3-3 protein theta

1

14

High-throughput

0.437

High

813631

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.437

High

926698

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

4

High-throughput

0.437

High

1045465

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

8

High-throughput

0.437

High

1164571

NHS
Actin remodeling regulator NHS

1

10

High-throughput

0.437

High

1167390

MPRIP
Myosin phosphatase Rho-interacting protein

1

15

High-throughput

0.437

High

1201343

SERC5
Serine incorporator 5

1

4

Small-scale

0.437

High

1252158

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1261283

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

1

High-throughput

0.437

High

1261299

Q9H4D1
Protein kinase

1

15

High-throughput

0.437

High

1261306

TMOD3
Tropomodulin-3

1

11

High-throughput

0.437

High

1261307

RAI14
Ankycorbin

1

17

High-throughput

0.437

High

883577

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.407

High

300494

FRYL
Protein furry homolog-like

2

0

High-throughput

0.328

High

1223583

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.328

High

1238227

NECA1
N-terminal EF-hand calcium-binding protein 1

2

0

High-throughput

0.328

High

1261286

F136A
Protein FAM136A

2

0

High-throughput

0.328

High

1223468

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.282

High

1136830

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1261281

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.279

Low

1261290

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.279

Low

47276

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

414012

GELS
Gelsolin

1

0

High-throughput

0.268

Low

660642

GRN
Progranulin

1

0

High-throughput

0.268

Low

1060477

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

1083718

FRDA
Frataxin, mitochondrial

1

0

High-throughput

0.268

Low

1135027

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

0

High-throughput

0.268

Low

1203615

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1261317

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1261287

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.249

Low

1261294

TPPC9
Trafficking protein particle complex subunit 9

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024