Protein: CRBN
Protein cereblon

Gene: CRBN
Organism: Homo sapiens
Interactions: 202
UniProt ID: Q96SW2

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082348

DDB1
DNA damage-binding protein 1

22

1

Small-scale

0.987

High

1033715

IKZF1
DNA-binding protein Ikaros

14

1

Small-scale

0.982

High

1302571

SALL4
Sal-like protein 4

7

2

Small-scale

0.966

High

1302573

IKZF3
Zinc finger protein Aiolos

6

1

Small-scale

0.947

High

822134

KC1A
Casein kinase I isoform alpha

5

0

Small-scale

0.898

High

1295661

ZFP91
E3 ubiquitin-protein ligase ZFP91

3

1

Small-scale

0.840

High

1302565

PAK5
Serine/threonine-protein kinase PAK 5

2

0

High-throughput

0.769

High

1043178

CUL4A
Cullin-4A

16

2

Small-scale

0.762

High

1025205

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

0

Small-scale

0.759

High

374735

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

2

Small-scale

0.754

High

1043531

CUL4B
Cullin-4B

7

2

Small-scale

0.747

High

921403

RBX1
E3 ubiquitin-protein ligase RBX1

8

0

Small-scale

0.714

High

545895

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

Small-scale

0.708

High

984012

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

Small-scale

0.708

High

849418

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

1

Small-scale

0.688

High

1272551

CSN5
COP9 signalosome complex subunit 5

3

1

Small-scale

0.656

High

1184951

CSN6
COP9 signalosome complex subunit 6

4

0

Small-scale

0.649

High

169730

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

3

Small-scale

0.647

High

312087

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

6

Small-scale

0.647

High

575548

EGR1
Early growth response protein 1

1

1

Small-scale

0.647

High

781424

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.647

High

983531

EGR4
Early growth response protein 4

1

2

Small-scale

0.647

High

1055106

HIC1
Hypermethylated in cancer 1 protein

1

1

Small-scale

0.647

High

1230262

BCL6B
B-cell CLL/lymphoma 6 member B protein

1

1

Small-scale

0.647

High

1231773

OSR2
Protein odd-skipped-related 2

1

1

Small-scale

0.647

High

1251825

OSR1
Protein odd-skipped-related 1

1

1

Small-scale

0.647

High

1294996

HIC2
Hypermethylated in cancer 2 protein

1

4

Small-scale

0.647

High

1302554

SALL3
Sal-like protein 3

1

2

Small-scale

0.647

High

1302562

SALL1
Sal-like protein 1

1

2

Small-scale

0.647

High

158010

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.630

High

1216195

TF2LY
Homeobox protein TGIF2LY

2

1

High-throughput

0.628

High

861900

PLK1
Serine/threonine-protein kinase PLK1

1

1

Small-scale

0.618

High

1302551

ZN692
Zinc finger protein 692

1

1

Small-scale

0.618

High

1302555

GZF1
GDNF-inducible zinc finger protein 1

1

0

Small-scale

0.614

High

1139257

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

0

High-throughput

0.602

High

1157601

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.602

High

154518

MEIS2
Homeobox protein Meis2

2

1

Small-scale

0.595

High

160729

AURKA
Aurora kinase A

1

0

High-throughput

0.586

High

835958

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.586

High

1069640

STK38
Serine/threonine-protein kinase 38

1

0

Small-scale

0.586

High

1302545

CSN8
COP9 signalosome complex subunit 8

2

0

Small-scale

0.585

High

432185

HS90A
Heat shock protein HSP 90-alpha

2

1

Small-scale

0.584

High

1302576

CSN3
COP9 signalosome complex subunit 3

2

2

Small-scale

0.584

High

1243511

DP13B
DCC-interacting protein 13-beta

2

1

High-throughput

0.576

High

656519

PSB4
Proteasome subunit beta type-4

1

1

Small-scale

0.573

High

904094

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

0

Small-scale

0.569

High

924807

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.569

High

395550

A4
Amyloid-beta precursor protein

2

1

Small-scale

0.563

High

387355

P53
Cellular tumor antigen p53

1

2

Small-scale

0.561

High

542911

BRAF
Serine/threonine-protein kinase B-raf

1

2

Small-scale

0.561

High

1302572

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.560

High

402374

JUN
Transcription factor Jun

2

0

Small-scale

0.559

High

1302550

CSN4
COP9 signalosome complex subunit 4

2

0

Small-scale

0.559

High

1302582

FBX7
F-box only protein 7

2

0

Small-scale

0.559

High

1068051

PDK1
[Pyruvate dehydrogenase

2

1

High-throughput

0.558

High

1267422

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

0

High-throughput

0.551

High

1274202

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.549

High

513756

CP19A
Aromatase

1

0

Small-scale

0.537

High

543059

GLNA
Glutamine synthetase

1

0

Small-scale

0.537

High

681570

DNJA1
DnaJ homolog subfamily A member 1

1

0

Small-scale

0.537

High

726370

BASI
Basigin

1

0

Small-scale

0.537

High

866991

MOT1
Monocarboxylate transporter 1

1

0

Small-scale

0.537

High

871745

HSP72
Heat shock-related 70 kDa protein 2

1

0

Small-scale

0.537

High

1036833

SQSTM
Sequestosome-1

1

0

Small-scale

0.537

High

1302567

ZMYM2
Zinc finger MYM-type protein 2

1

0

Small-scale

0.537

High

724040

CLCN1
Chloride channel protein 1

2

3

Small-scale

0.533

High

529609

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

642985

S10A4
Protein S100-A4

1

0

High-throughput

0.513

High

1273387

GLMN
Glomulin

1

0

High-throughput

0.513

High

871056

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

1

Small-scale

0.501

High

895888

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

1

Small-scale

0.501

High

908266

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

2

Small-scale

0.501

High

47297

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.493

High

203771

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.486

High

232449

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.486

High

321817

WIZ
Protein Wiz

1

0

Small-scale

0.480

High

643391

HMGB2
High mobility group protein B2

1

0

Small-scale

0.480

High

927436

1433Z
14-3-3 protein zeta/delta

1

0

Small-scale

0.480

High

1060884

IMB1
Importin subunit beta-1

1

0

Small-scale

0.480

High

1302566

HDAC6
Histone deacetylase 6

1

0

Small-scale

0.480

High

1302575

ELF5
ETS-related transcription factor Elf-5

1

0

Small-scale

0.480

High

241356

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

1

Small-scale

0.479

High

335169

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

Small-scale

0.479

High

415458

ATPB
ATP synthase subunit beta, mitochondrial

1

1

Small-scale

0.479

High

420788

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.479

High

432878

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

2

Small-scale

0.479

High

438456

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.479

High

488786

ARAF
Serine/threonine-protein kinase A-Raf

1

2

Small-scale

0.479

High

515928

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

Small-scale

0.479

High

539117

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

Small-scale

0.479

High

541119

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

Small-scale

0.479

High

573432

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.479

High

610013

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

Small-scale

0.479

High

637026

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.479

High

641902

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

Small-scale

0.479

High

727002

FUS
RNA-binding protein FUS

1

2

Small-scale

0.479

High

745274

RBMX
RNA-binding motif protein, X chromosome

1

3

Small-scale

0.479

High

749803

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

770994

TCPZ
T-complex protein 1 subunit zeta

1

1

Small-scale

0.479

High

794086

MATR3
Matrin-3

1

1

Small-scale

0.479

High

805555

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

1

Small-scale

0.479

High

821373

TCPE
T-complex protein 1 subunit epsilon

1

1

Small-scale

0.479

High

836766

DNLI3
DNA ligase 3

1

1

Small-scale

0.479

High

836868

DNLI4
DNA ligase 4

1

1

Small-scale

0.479

High

843002

TCPQ
T-complex protein 1 subunit theta

1

2

Small-scale

0.479

High

853041

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

Small-scale

0.479

High

893458

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

Small-scale

0.479

High

896188

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

897298

CSN2
COP9 signalosome complex subunit 2

1

2

Small-scale

0.479

High

898716

RL26
Large ribosomal subunit protein uL24

1

1

Small-scale

0.479

High

911942

RUXF
Small nuclear ribonucleoprotein F

1

1

Small-scale

0.479

High

912362

SMD1
Small nuclear ribonucleoprotein Sm D1

1

2

Small-scale

0.479

High

912712

SMD3
Small nuclear ribonucleoprotein Sm D3

1

2

Small-scale

0.479

High

928003

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

Small-scale

0.479

High

1024209

CSN1
COP9 signalosome complex subunit 1

1

1

Small-scale

0.479

High

1041157

CUL1
Cullin-1

1

2

Small-scale

0.479

High

1262276

SPRY4
SPRY domain-containing protein 4

1

1

Small-scale

0.479

High

1302546

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

Small-scale

0.479

High

1302549

PCGF1
Polycomb group RING finger protein 1

1

1

High-throughput

0.479

High

1302556

P63
Tumor protein 63

1

2

Small-scale

0.479

High

1302559

CSN7B
COP9 signalosome complex subunit 7b

1

1

Small-scale

0.479

High

1302568

CSN7A
COP9 signalosome complex subunit 7a

1

1

Small-scale

0.479

High

1302570

RABX5
Rab5 GDP/GTP exchange factor

1

1

Small-scale

0.479

High

1302578

RUVB2
RuvB-like 2

1

1

Small-scale

0.479

High

1302579

RUVB1
RuvB-like 1

1

1

Small-scale

0.479

High

1302584

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

61982

FA83G
Protein FAM83G

1

0

Small-scale

0.458

High

170704

AXIN1
Axin-1

1

0

Small-scale

0.458

High

201404

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

207483

LAT
Linker for activation of T-cells family member 1

1

0

Small-scale

0.458

High

228443

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

314379

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

323980

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.458

High

417836

DPOLB
DNA polymerase beta

1

0

Small-scale

0.458

High

437450

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

445499

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

495596

THIO
Thioredoxin

1

0

Small-scale

0.458

High

518745

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.458

High

534138

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.458

High

571561

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

579731

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

585043

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

602569

COMT
Catechol O-methyltransferase

1

0

Small-scale

0.458

High

611493

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

0

Small-scale

0.458

High

626235

APC
Adenomatous polyposis coli protein

1

0

Small-scale

0.458

High

637731

PSA2
Proteasome subunit alpha type-2

1

0

Small-scale

0.458

High

717296

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

790519

RL35
Large ribosomal subunit protein uL29

1

0

Small-scale

0.458

High

855711

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.458

High

867462

ICLN
Methylosome subunit pICln

1

0

Small-scale

0.458

High

875245

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

898444

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.458

High

899824

RL27
Large ribosomal subunit protein eL27

1

0

Small-scale

0.458

High

907464

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.458

High

920536

RS25
Small ribosomal subunit protein eS25

1

0

Small-scale

0.458

High

929040

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

952092

SRSF3
Serine/arginine-rich splicing factor 3

1

0

Small-scale

0.458

High

959623

VIGLN
Vigilin

1

0

High-throughput

0.458

High

962300

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

Small-scale

0.458

High

967948

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

984116

SRS11
Serine/arginine-rich splicing factor 11

1

0

Small-scale

0.458

High

1016472

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

0

Small-scale

0.458

High

1018858

SF3A3
Splicing factor 3A subunit 3

1

0

Small-scale

0.458

High

1019606

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.458

High

1032140

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

Small-scale

0.458

High

1047222

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

Small-scale

0.458

High

1067803

PDIA6
Protein disulfide-isomerase A6

1

0

Small-scale

0.458

High

1164459

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

Small-scale

0.458

High

1183757

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1187466

APTX
Aprataxin

1

0

Small-scale

0.458

High

1260148

TM263
Transmembrane protein 263

1

0

Small-scale

0.458

High

1288189

CMBL
Carboxymethylenebutenolidase homolog

1

0

Small-scale

0.458

High

1302547

MEP50
Methylosome protein WDR77

1

0

Small-scale

0.458

High

1302548

RIOK1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.458

High

1302552

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

1

0

Small-scale

0.458

High

1302557

BOLA2
BolA-like protein 2

1

0

Small-scale

0.458

High

1302558

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1302560

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1302561

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1302563

PIHD1
PIH1 domain-containing protein 1

1

0

Small-scale

0.458

High

1302564

DJB12
DnaJ homolog subfamily B member 12

1

0

Small-scale

0.458

High

1302574

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

1302581

RTCB
RNA-splicing ligase RtcB homolog

1

0

Small-scale

0.458

High

1302583

3BP1
SH3 domain-binding protein 1

1

0

Small-scale

0.458

High

1302585

SPIN1
Spindlin-1

1

0

Small-scale

0.458

High

1302586

NS1BP
Influenza virus NS1A-binding protein

1

0

Small-scale

0.458

High

828161

DHE4
Glutamate dehydrogenase 2, mitochondrial

1

1

Small-scale

0.437

High

850294

CLCN2
Chloride channel protein 2

1

3

Small-scale

0.437

High

1054523

RBM39
RNA-binding protein 39

1

3

Small-scale

0.437

High

1289238

RMXL1
RNA binding motif protein, X-linked-like-1

1

4

Small-scale

0.437

High

1302569

PUF60
Poly(U)-binding-splicing factor PUF60

1

3

Small-scale

0.437

High

1302577

RL26L
Ribosomal protein uL24-like

1

1

Small-scale

0.437

High

497473

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1301367

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

81556

B7Z207
Protein-serine/threonine kinase

1

1

High-throughput

0.407

High

351795

CALC
Calcitonin [Cleaved into: Calcitonin; Katacalcin

1

1

High-throughput

0.407

High

655094

PROP
Properdin

2

0

High-throughput

0.328

High

1217886

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.316

High

1283716

COQA1
Collagen alpha-1(XXVI) chain

1

0

High-throughput

0.268

Low

1169372

KRBA2
KRAB-A domain-containing protein 2

1

0

Small-scale

0.249

Low

1302553

DDA1
DET1- and DDB1-associated protein 1

1

0

Small-scale

0.249

Low

1302580

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024