Protein: HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2 (Cardiovascular helix-loop-helix factor 1) (hCHF1) (Class B basic helix-loop-helix protein 32) (bHLHb32) (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (hHRT2) (Protein gridlock homolog)

Gene: HEY2
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q9UBP5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1354209

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

6

18

Small-scale

0.946

High

1136619

FHL5
Four and a half LIM domains protein 5

2

2

High-throughput

0.783

High

1344044

PDLI7
PDZ and LIM domain protein 7

2

0

High-throughput

0.742

High

1023832

TRAF1
TNF receptor-associated factor 1

3

3

High-throughput

0.675

High

330433

HAND1
Heart- and neural crest derivatives-expressed protein 1

1

17

Small-scale

0.647

High

1054249

HES1
Transcription factor HES-1

1

18

Small-scale

0.647

High

649169

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

7

Small-scale

0.621

High

1237807

ARL10
ADP-ribosylation factor-like protein 10

3

3

High-throughput

0.609

High

830044

HXA1
Homeobox protein Hox-A1

2

5

High-throughput

0.606

High

1313378

TRAF4
TNF receptor-associated factor 4

2

3

High-throughput

0.606

High

1336684

CHM1A
Charged multivesicular body protein 1a

2

0

High-throughput

0.602

High

867073

IST1
IST1 homolog

2

0

High-throughput

0.585

High

1204107

CARM1
Histone-arginine methyltransferase CARM1

2

0

High-throughput

0.585

High

792046

HD
Huntingtin

1

2

High-throughput

0.582

High

253221

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1289464

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

Small-scale

0.578

High

1274271

RBPMS
RNA-binding protein with multiple splicing

1

3

High-throughput

0.573

High

261602

NCOR1
Nuclear receptor corepressor 1

1

2

Small-scale

0.561

High

642176

KRA59
Keratin-associated protein 5-9

2

4

High-throughput

0.553

High

991685

KRA11
Keratin-associated protein 1-1

2

3

High-throughput

0.553

High

1109168

KRA61
Keratin-associated protein 6-1

2

3

High-throughput

0.553

High

1109277

KRA62
Keratin-associated protein 6-2

2

5

High-throughput

0.553

High

1216057

KRA81
Keratin-associated protein 8-1

2

1

High-throughput

0.553

High

1317328

KRA44
Keratin-associated protein 4-4

2

4

High-throughput

0.553

High

417442

ENOA
Alpha-enolase

1

1

High-throughput

0.541

High

868784

ATX1
Ataxin-1

1

2

High-throughput

0.541

High

271898

SPB7
Serpin B7

1

4

High-throughput

0.536

High

504894

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.536

High

1220830

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.529

High

170161

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

1038776

HDAC1
Histone deacetylase 1

1

6

Small-scale

0.501

High

259896

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

1

High-throughput

0.489

High

1218309

SPA12
Serpin A12

1

4

High-throughput

0.489

High

1229796

PGAM4
Probable phosphoglycerate mutase 4

1

1

High-throughput

0.489

High

472734

FBSP1
F-box/SPRY domain-containing protein 1

1

5

Small-scale

0.479

High

987007

SUH
Recombining binding protein suppressor of hairless

1

1

Small-scale

0.479

High

1198701

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

1302463

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

1354206

SE1L1
Protein sel-1 homolog 1

1

1

Small-scale

0.479

High

1354207

HDAC9
Histone deacetylase 9

1

7

Small-scale

0.479

High

1354208

FBW1A
F-box/WD repeat-containing protein 1A

1

7

Small-scale

0.479

High

788232

CASP3
Caspase-3

1

0

Small-scale

0.458

High

483808

HS71B
Heat shock 70 kDa protein 1B

1

5

High-throughput

0.445

High

1326106

DERL2
Derlin-2

1

1

Small-scale

0.437

High

47488

RPSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.426

High

67390

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1216028

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

1317383

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.316

High

836341

KLK7
Kallikrein-7

1

0

High-throughput

0.279

Low

1165496

SBSN
Suprabasin

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024