Protein: SPTC2
Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

Gene: SPTC2, SPTLC2
Organism: Homo sapiens
Interactions: 77
UniProt ID: O15270

Gene Ontology (top 5):
GO:0004758 - serine C-palmitoyltransferase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006686 - sphingomyelin biosynthetic process
GO:0017059 - serine palmitoyltransferase complex
GO:0030148 - sphingolipid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

174020

SPTC1
Serine palmitoyltransferase 1

2

10

Small-scale

0.783

High

174200

EVA1C
Protein eva-1 homolog C

3

1

High-throughput

0.609

High

174227

SPTSB
Serine palmitoyltransferase small subunit B

1

5

Small-scale

0.590

High

174230

SPTSA
Serine palmitoyltransferase small subunit A

1

5

Small-scale

0.590

High

174219

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

1

High-throughput

0.574

High

174186

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.536

High

174189

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

174196

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.536

High

174237

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.536

High

174181

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.533

High

174204

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

0

High-throughput

0.513

High

174206

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

174232

BSCL2
Seipin

1

0

High-throughput

0.513

High

174233

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

174201

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.489

High

174207

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

174220

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.489

High

174229

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.489

High

174238

TSN10
Tetraspanin-10

1

1

High-throughput

0.489

High

174240

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.489

High

174243

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

174250

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.489

High

174251

PCDGL
Protocadherin gamma-C4

1

1

High-throughput

0.489

High

174249

NOTC3
Neurogenic locus notch homolog protein 3

1

0

Small-scale

0.480

High

163668

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

174184

EGFR
Epidermal growth factor receptor

1

2

Small-scale

0.479

High

174216

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

174236

DERL1
Derlin-1

1

1

High-throughput

0.479

High

174194

CCNF
Cyclin-F

1

1

High-throughput

0.470

High

174198

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

0

High-throughput

0.458

High

174235

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

174212

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.445

High

174180

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

174185

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

174187

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

174188

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

174190

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

174191

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

174192

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

174197

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

174199

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

174205

CUL3
Cullin-3

1

2

High-throughput

0.437

High

174211

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

174215

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

174217

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

174218

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

174223

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.437

High

174226

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.437

High

174239

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

174241

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

174245

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.437

High

174247

UBQL2
Ubiquilin-2

1

3

High-throughput

0.437

High

47664

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

99519

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

174242

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.407

High

174179

SPIT2
Kunitz-type protease inhibitor 2

3

0

High-throughput

0.347

High

174210

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

2

0

High-throughput

0.318

High

174182

CSCL1
CSC1-like protein 1

1

0

High-throughput

0.279

Low

174195

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.279

Low

174213

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

174214

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

174221

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.279

Low

174224

MYCT1
Myc target protein 1

1

0

High-throughput

0.279

Low

174225

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.279

Low

174228

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.279

Low

174203

ROM1
Rod outer segment membrane protein 1

1

0

High-throughput

0.269

Low

174183

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.249

Low

174193

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

174202

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

0

High-throughput

0.249

Low

174208

EREP1
Endosomal transmembrane epsin interactor 1

1

0

High-throughput

0.249

Low

174209

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

174222

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

174231

WBP1
WW domain-binding protein 1

1

0

High-throughput

0.249

Low

174234

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.249

Low

174244

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

174246

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

High-throughput

0.249

Low

174248

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024