Protein: GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)

Gene: GNAI3
Organism: Homo sapiens
Interactions: 200
UniProt ID: P08754

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444705

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

7

20

Small-scale

0.966

High

207507

RGS14
Regulator of G-protein signaling 14

7

20

Small-scale

0.965

High

444752

GPSM1
G-protein-signaling modulator 1

5

15

Small-scale

0.935

High

444813

GPSM3
G-protein-signaling modulator 3

4

3

High-throughput

0.904

High

158599

RGS12
Regulator of G-protein signaling 12

4

20

Small-scale

0.902

High

444795

RIC8A
Synembryn-A

4

14

Small-scale

0.902

High

444706

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

4

20

Small-scale

0.899

High

444791

GBB4
Guanine nucleotide-binding protein subunit beta-4

4

20

Small-scale

0.899

High

444691

RGS19
Regulator of G-protein signaling 19

4

20

Small-scale

0.896

High

444707

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

4

11

High-throughput

0.895

High

444686

MTR1A
Melatonin receptor type 1A

3

20

Small-scale

0.866

High

391309

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

11

High-throughput

0.861

High

444650

GNAO

3

11

High-throughput

0.861

High

444661

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

3

11

High-throughput

0.861

High

444685

RPGP1
Rap1 GTPase-activating protein 1

3

4

High-throughput

0.861

High

444714

GPSM2
G-protein-signaling modulator 2

3

14

Small-scale

0.849

High

444753

PCP2
Purkinje cell protein 2 homolog

4

11

High-throughput

0.796

High

444688

MTR1B
Melatonin receptor type 1B

2

19

Small-scale

0.789

High

444800

RGS18
Regulator of G-protein signaling 18

2

20

Small-scale

0.778

High

180652

RGS16
Regulator of G-protein signaling 16

2

20

Small-scale

0.768

High

182442

RGS5
Regulator of G-protein signaling 5

2

20

Small-scale

0.768

High

444664

S1PR1
Sphingosine 1-phosphate receptor 1

1

20

Small-scale

0.740

High

444806

RGS17
Regulator of G-protein signaling 17

1

20

High-throughput

0.740

High

210409

RGS10
Regulator of G-protein signaling 10

1

20

Small-scale

0.724

High

444740

GRDN
Girdin

4

7

Small-scale

0.700

High

229234

GBG7

3

20

High-throughput

0.667

High

444694

GBG4

3

20

High-throughput

0.667

High

444695

GBG10

3

20

High-throughput

0.667

High

444701

GBG11

3

20

High-throughput

0.667

High

444710

GBG5

3

20

High-throughput

0.667

High

444751

AN13B
Ankyrin repeat domain-containing protein 13B

3

1

High-throughput

0.667

High

444768

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

3

5

High-throughput

0.667

High

444802

DAPLE
Protein Daple

3

8

Small-scale

0.664

High

444680

RGS2
Regulator of G-protein signaling 2

1

20

Small-scale

0.647

High

444779

ACE2
Angiotensin-converting enzyme 2

3

3

Small-scale

0.640

High

444697

CLH2
Clathrin heavy chain 2

3

0

High-throughput

0.638

High

444776

DCNL5
DCN1-like protein 5

3

0

High-throughput

0.638

High

444777

NDC1
Nucleoporin NDC1

3

0

High-throughput

0.638

High

444785

TM222
Transmembrane protein 222

3

0

High-throughput

0.638

High

337807

EGFR
Epidermal growth factor receptor

2

9

Small-scale

0.624

High

254146

FZD7
Frizzled-7

1

2

Small-scale

0.618

High

428884

ADRB2
Beta-2 adrenergic receptor

1

11

High-throughput

0.618

High

444660

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

20

Small-scale

0.618

High

444665

CNR1
Cannabinoid receptor 1

1

20

Small-scale

0.618

High

444682

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

444692

RGS3
Regulator of G-protein signaling 3

1

20

Small-scale

0.618

High

444693

RGS7
Regulator of G-protein signaling 7

1

20

Small-scale

0.618

High

444702

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.618

High

444790

ECT2
Protein ECT2

1

16

High-throughput

0.618

High

444797

AAAS
Aladin

1

2

High-throughput

0.618

High

444700

CD81
CD81 antigen

2

7

Small-scale

0.601

High

349815

RASK
GTPase KRas

2

13

High-throughput

0.584

High

384130

NTRK1
High affinity nerve growth factor receptor

2

7

High-throughput

0.584

High

444679

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

444796

ANLN
Anillin

2

9

High-throughput

0.584

High

444811

PHF24
PHD finger protein 24

2

0

High-throughput

0.580

High

444666

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

16

Small-scale

0.575

High

444672

CALX
Calnexin

2

1

High-throughput

0.571

High

444743

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

444676

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

2

Small-scale

0.561

High

444733

RASA3
Ras GTPase-activating protein 3

1

16

Small-scale

0.561

High

444744

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.553

High

303573

SOX30
Transcription factor SOX-30

1

3

High-throughput

0.541

High

444698

AT12A
Potassium-transporting ATPase alpha chain 2

1

6

High-throughput

0.541

High

444669

AVR2A
Activin receptor type-2A

1

3

High-throughput

0.536

High

444674

UFO
Tyrosine-protein kinase receptor UFO

1

10

High-throughput

0.536

High

444723

STK3
Serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

444750

PIM3
Serine/threonine-protein kinase pim-3

1

5

High-throughput

0.536

High

444755

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

444762

TBCK
TBC domain-containing protein kinase-like protein

1

4

High-throughput

0.536

High

444764

HASP
Serine/threonine-protein kinase haspin

1

4

High-throughput

0.536

High

444794

KC1G1
Casein kinase I isoform gamma-1

1

1

High-throughput

0.536

High

444803

PAK5
Serine/threonine-protein kinase PAK 5

1

10

High-throughput

0.536

High

444809

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.536

High

444670

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

444678

BASI
Basigin

1

3

High-throughput

0.515

High

362720

FINC
Fibronectin

1

0

High-throughput

0.513

High

444725

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

444746

RHDF2
Inactive rhomboid protein 2

1

0

High-throughput

0.513

High

444801

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

444659

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.500

High

444699

EPHA4
Ephrin type-A receptor 4

1

6

High-throughput

0.500

High

444736

NTRK2
BDNF/NT-3 growth factors receptor

1

7

High-throughput

0.500

High

157285

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

3

High-throughput

0.489

High

444683

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.481

High

444713

NUCB2
Nucleobindin-2

1

7

High-throughput

0.481

High

444719

NUCB1
Nucleobindin-1

1

7

High-throughput

0.481

High

119102

LEG9
Galectin-9

1

2

High-throughput

0.479

High

155249

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

167808

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

177795

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.479

High

179522

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

204955

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

212724

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

233161

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

308339

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

324181

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

345741

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

429800

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

436127

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

444651

FURIN
Furin

1

2

High-throughput

0.479

High

444652

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

444654

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.479

High

444655

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

444656

IFM1
Interferon-induced transmembrane protein 1

1

5

High-throughput

0.479

High

444658

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

444663

NCF2
Neutrophil cytosol factor 2

1

2

Small-scale

0.479

High

444667

OSBP1
Oxysterol-binding protein 1

1

2

High-throughput

0.479

High

444671

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

444677

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

444681

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.479

High

444684

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

444687

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

444689

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

444696

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

444703

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

444708

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.479

High

444709

GBG3

1

20

High-throughput

0.479

High

444711

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.479

High

444712

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

444715

VIGLN
Vigilin

1

1

High-throughput

0.479

High

444716

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

444718

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

444721

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

10

High-throughput

0.479

High

444722

TFCP2
Alpha-globin transcription factor CP2

1

9

High-throughput

0.479

High

444726

GAB1
GRB2-associated-binding protein 1

1

9

Small-scale

0.479

High

444730

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

444734

TNIP1
TNFAIP3-interacting protein 1

1

11

High-throughput

0.479

High

444735

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

444737

FSCN1
Fascin

1

1

High-throughput

0.479

High

444739

DUS6
Dual specificity protein phosphatase 6

1

16

High-throughput

0.479

High

444741

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

444742

MIDN
Midnolin

1

3

High-throughput

0.479

High

444747

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

444756

NIN
Ninein

1

4

High-throughput

0.479

High

444757

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

444759

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

444760

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.479

High

444763

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

10

High-throughput

0.479

High

444765

CLC4D
C-type lectin domain family 4 member D

1

4

High-throughput

0.479

High

444767

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

444770

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

444771

OPTN
Optineurin

1

10

High-throughput

0.479

High

444774

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

7

High-throughput

0.479

High

444775

DUS9
Dual specificity protein phosphatase 9

1

16

High-throughput

0.479

High

444783

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

444784

SIK2
Serine/threonine-protein kinase SIK2

1

1

Small-scale

0.479

High

444786

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

444788

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

444789

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

444792

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

444793

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

9

High-throughput

0.479

High

444798

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

444799

DUS22
Dual specificity protein phosphatase 22

1

15

High-throughput

0.479

High

444804

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

444805

HDAC6
Histone deacetylase 6

1

7

High-throughput

0.479

High

444807

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

444810

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.479

High

444812

RNF6
E3 ubiquitin-protein ligase RNF6

1

3

High-throughput

0.479

High

444814

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

299307

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

444668

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

444673

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

444690

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

444704

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

444720

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

444724

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

444732

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

444754

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

444778

DERL1
Derlin-1

1

0

High-throughput

0.458

High

444780

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.458

High

444781

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

444808

SEPT9
Septin-9

1

0

Small-scale

0.458

High

444815

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

0

High-throughput

0.458

High

444816

ALG6
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.458

High

150667

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

10

Small-scale

0.457

High

239724

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

444653

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

444657

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.445

High

444717

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

444727

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

444728

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.445

High

444731

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

444745

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

444748

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.445

High

444758

CD177
CD177 antigen

1

5

Small-scale

0.445

High

444772

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

High-throughput

0.445

High

444773

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

444782

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

328709

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

444729

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

3

High-throughput

0.437

High

444738

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.437

High

444766

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

444769

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.437

High

444787

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

2

Small-scale

0.437

High

444662

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

47668

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

444749

PKHH3
Pleckstrin homology domain-containing family H member 3

1

0

High-throughput

0.279

Low

444675

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.249

Low

444761

RDH13
Retinol dehydrogenase 13

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024