Protein: MKRN2
E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)

Gene: MKRN2
Organism: Homo sapiens
Interactions: 201
UniProt ID: Q9H000

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849442

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

14

Small-scale

0.905

High

1327018

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

14

High-throughput

0.871

High

442479

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

20

High-throughput

0.861

High

1308763

RBM4B
RNA-binding protein 4B

3

20

High-throughput

0.861

High

1326983

PAR12
Protein mono-ADP-ribosyltransferase PARP12

3

3

High-throughput

0.861

High

181249

NUP42
Nucleoporin NUP42

3

1

High-throughput

0.847

High

929651

RACK1
Small ribosomal subunit protein RACK1

3

3

High-throughput

0.845

High

128297

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

16

Small-scale

0.834

High

1020327

ELAV2
ELAV-like protein 2

2

19

High-throughput

0.811

High

1201660

ZCH18
Zinc finger CCCH domain-containing protein 18

2

3

High-throughput

0.811

High

228631

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.754

High

516684

PABP1
Polyadenylate-binding protein 1

2

11

High-throughput

0.754

High

1031454

PABP4
Polyadenylate-binding protein 4

2

11

High-throughput

0.754

High

1327004

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

8

High-throughput

0.754

High

1162376

ZC3HE
Zinc finger CCCH domain-containing protein 14

2

0

High-throughput

0.748

High

1326981

PAIP1
Polyadenylate-binding protein-interacting protein 1

4

3

High-throughput

0.694

High

62097

EPAB2
Embryonic polyadenylate-binding protein 2

1

18

High-throughput

0.691

High

71229

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

12

High-throughput

0.691

High

241362

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

12

High-throughput

0.691

High

432912

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

16

High-throughput

0.691

High

945346

PRR3
Proline-rich protein 3

1

2

High-throughput

0.691

High

952116

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.691

High

1073854

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

20

High-throughput

0.691

High

1201161

THOC4
THO complex subunit 4

1

10

High-throughput

0.691

High

1288624

PABP5
Polyadenylate-binding protein 5

1

11

High-throughput

0.691

High

1025957

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.665

High

932574

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

15

Small-scale

0.647

High

1233650

CARME
Carnosine N-methyltransferase

3

0

High-throughput

0.638

High

896373

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

18

High-throughput

0.621

High

919857

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

14

High-throughput

0.621

High

47858

RBM47
RNA-binding protein 47

1

16

High-throughput

0.618

High

162144

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

18

High-throughput

0.618

High

202275

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

15

High-throughput

0.618

High

209477

PLRG1
Pleiotropic regulator 1

1

3

High-throughput

0.618

High

236055

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

16

High-throughput

0.618

High

644322

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.618

High

668423

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

20

High-throughput

0.618

High

925122

TRA2B
Transformer-2 protein homolog beta

1

17

High-throughput

0.618

High

943898

RAE1L
mRNA export factor RAE1

1

3

High-throughput

0.618

High

1023557

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

8

High-throughput

0.618

High

1040409

TRA2A
Transformer-2 protein homolog alpha

1

14

High-throughput

0.618

High

1158122

DHX57
Putative ATP-dependent RNA helicase DHX57

1

5

High-throughput

0.618

High

1199044

PABP2
Polyadenylate-binding protein 2

1

17

High-throughput

0.618

High

1219232

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

1

High-throughput

0.618

High

1260902

DCAF4
DDB1- and CUL4-associated factor 4

1

2

High-throughput

0.618

High

1272093

CELF1
CUGBP Elav-like family member 1

1

19

High-throughput

0.618

High

1272477

DAZL
Deleted in azoospermia-like

1

15

High-throughput

0.618

High

1310851

TRI56
E3 ubiquitin-protein ligase TRIM56

1

3

High-throughput

0.618

High

1314615

RBM4
RNA-binding protein 4

1

20

Small-scale

0.618

High

1316868

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

19

High-throughput

0.618

High

1319044

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

15

High-throughput

0.618

High

1326988

RC3H2
Roquin-2

1

5

High-throughput

0.618

High

1326990

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

4

High-throughput

0.618

High

1327000

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

High-throughput

0.618

High

1327005

UBQL2
Ubiquilin-2

1

1

High-throughput

0.618

High

1327010

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.618

High

1327011

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.618

High

1327024

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

10

High-throughput

0.618

High

1304932

NECD
Necdin

2

3

High-throughput

0.613

High

1268162

LAR4B
La-related protein 4B

2

11

High-throughput

0.611

High

1327017

TR150
Thyroid hormone receptor-associated protein 3

2

6

High-throughput

0.611

High

1156940

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

3

1

High-throughput

0.609

High

1327003

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.602

High

91651

E9KL35
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.594

High

1327020

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.586

High

256575

ZC11A
Zinc finger CCCH domain-containing protein 11A

2

0

High-throughput

0.585

High

1152530

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

2

11

High-throughput

0.584

High

1305687

ATX2
Ataxin-2

2

3

High-throughput

0.584

High

387473

P53
Cellular tumor antigen p53

1

1

Small-scale

0.578

High

1172886

NKAP1
Uncharacterized protein NKAPD1

2

2

High-throughput

0.574

High

791961

HD
Huntingtin

2

0

High-throughput

0.571

High

989109

FMR1
Fragile X messenger ribonucleoprotein 1

2

0

High-throughput

0.559

High

1121113

GLE1
mRNA export factor GLE1

2

0

High-throughput

0.559

High

1326997

AIRIM
AFG2-interacting ribosome maturation factor

1

0

High-throughput

0.549

High

1317078

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

High-throughput

0.541

High

978890

TF65
Transcription factor p65

1

0

Small-scale

0.537

High

230425

ZC3H1
Zinc finger C3H1 domain-containing protein

1

3

High-throughput

0.536

High

321196

PTBP3
Polypyrimidine tract-binding protein 3

1

14

High-throughput

0.536

High

1080317

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.536

High

1092904

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

4

High-throughput

0.536

High

1167307

BCOR
BCL-6 corepressor

1

6

Small-scale

0.536

High

1326982

SHRPN
Sharpin

1

2

High-throughput

0.536

High

1327001

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.536

High

1327008

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

2

High-throughput

0.536

High

1295736

PDLI2
PDZ and LIM domain protein 2

1

0

Small-scale

0.529

High

72163

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

16

High-throughput

0.528

High

607159

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

0

High-throughput

0.513

High

1245174

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

833815

CLK1
Dual specificity protein kinase CLK1

1

3

High-throughput

0.501

High

1266802

TM9S4
Transmembrane 9 superfamily member 4

1

1

High-throughput

0.489

High

163248

XPO1
Exportin-1

1

1

High-throughput

0.479

High

257405

CNOT3
CCR4-NOT transcription complex subunit 3

1

1

High-throughput

0.479

High

269057

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.479

High

272705

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.479

High

298785

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

379846

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

431043

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

455849

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

509115

TOP2A
DNA topoisomerase 2-alpha

1

2

High-throughput

0.479

High

626245

APC
Adenomatous polyposis coli protein

1

4

High-throughput

0.479

High

725008

MYH9
Myosin-9

1

1

High-throughput

0.479

High

725240

MYH10
Myosin-10

1

1

High-throughput

0.479

High

749848

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

783109

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

821035

PRC2A
Protein PRRC2A

1

4

High-throughput

0.479

High

893151

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

966642

OTUD4
OTU domain-containing protein 4

1

2

High-throughput

0.479

High

988802

PAX8
Paired box protein Pax-8

1

2

Small-scale

0.479

High

991876

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

High-throughput

0.479

High

1022201

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

1042499

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1049885

UBP2L
Ubiquitin-associated protein 2-like

1

2

High-throughput

0.479

High

1056740

PUM1
Pumilio homolog 1

1

4

High-throughput

0.479

High

1065022

R3HD1
R3H domain-containing protein 1

1

4

High-throughput

0.479

High

1089561

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

14

High-throughput

0.479

High

1119481

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.479

High

1123131

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.479

High

1127694

PRC2B
Protein PRRC2B

1

3

High-throughput

0.479

High

1136281

RC3H1
Roquin-1

1

2

High-throughput

0.479

High

1139517

TUT7
Terminal uridylyltransferase 7

1

1

High-throughput

0.479

High

1145705

LAR1B
La-related protein 1B

1

11

High-throughput

0.479

High

1148209

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

1162679

LARP1
La-related protein 1

1

11

High-throughput

0.479

High

1174850

LARP4
La-related protein 4

1

11

High-throughput

0.479

High

1187768

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

5

High-throughput

0.479

High

1192373

YTHD3
YTH domain-containing family protein 3

1

2

High-throughput

0.479

High

1198384

PATL1
Protein PAT1 homolog 1

1

1

High-throughput

0.479

High

1217472

PKHH2
Pleckstrin homology domain-containing family H member 2

1

1

High-throughput

0.479

High

1232203

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

2

High-throughput

0.479

High

1238444

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

1

High-throughput

0.479

High

1242127

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.479

High

1242648

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

4

High-throughput

0.479

High

1245983

TDRD7
Tudor domain-containing protein 7

1

1

High-throughput

0.479

High

1252120

PUM2
Pumilio homolog 2

1

4

High-throughput

0.479

High

1255206

BRX1
Ribosome biogenesis protein BRX1 homolog

1

6

High-throughput

0.479

High

1266675

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

1272343

RENT1
Regulator of nonsense transcripts 1

1

7

High-throughput

0.479

High

1294247

FUBP3
Far upstream element-binding protein 3

1

11

High-throughput

0.479

High

1300076

SMG1
Serine/threonine-protein kinase SMG1

1

1

High-throughput

0.479

High

1303727

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.479

High

1308699

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

2

High-throughput

0.479

High

1326984

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1326987

AGO3
Protein argonaute-3

1

3

High-throughput

0.479

High

1326989

MOV10
Helicase MOV-10

1

7

High-throughput

0.479

High

1326992

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

1

High-throughput

0.479

High

1326995

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

1

High-throughput

0.479

High

1326996

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

10

High-throughput

0.479

High

1326998

BCLF1
Bcl-2-associated transcription factor 1

1

5

High-throughput

0.479

High

1326999

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

2

High-throughput

0.479

High

1327002

SYLC
Leucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

1327006

AGO2
Protein argonaute-2

1

3

High-throughput

0.479

High

1327007

AGO1
Protein argonaute-1

1

3

High-throughput

0.479

High

1327009

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.479

High

1327013

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

High-throughput

0.479

High

1327014

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

High-throughput

0.479

High

1327016

R3HD2
R3H domain-containing protein 2

1

3

High-throughput

0.479

High

1327019

LC7L2
Putative RNA-binding protein Luc7-like 2

1

3

High-throughput

0.479

High

1327021

PRC2C
Protein PRRC2C

1

2

High-throughput

0.479

High

1327022

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

61460

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

328950

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

685015

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

1051675

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1053981

CAPR1
Caprin-1

1

0

High-throughput

0.458

High

1058295

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

High-throughput

0.458

High

1076288

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1100928

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1109630

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

1168833

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.458

High

1240979

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1242046

RN214
RING finger protein 214

1

0

High-throughput

0.458

High

1260243

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

1267864

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1300332

UIF
UAP56-interacting factor

1

0

High-throughput

0.458

High

1302663

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.458

High

1326985

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1326986

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

1326991

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.458

High

1326994

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

70198

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

11

High-throughput

0.445

High

1284316

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

11

High-throughput

0.445

High

317349

PCNT
Pericentrin

1

2

High-throughput

0.437

High

632395

TNR6
Tumor necrosis factor receptor superfamily member 6

1

3

High-throughput

0.437

High

1075869

TRIPB
Thyroid receptor-interacting protein 11

1

2

High-throughput

0.437

High

1159089

CEP85
Centrosomal protein of 85 kDa

1

3

High-throughput

0.437

High

1253997

ALMS1
Centrosome-associated protein ALMS1

1

1

High-throughput

0.437

High

1255686

RBCC1
RB1-inducible coiled-coil protein 1

1

2

High-throughput

0.437

High

1327012

CP131
Centrosomal protein of 131 kDa

1

3

High-throughput

0.437

High

1327015

ANR26
Ankyrin repeat domain-containing protein 26

1

4

High-throughput

0.437

High

968653

TAGL
Transgelin

1

0

High-throughput

0.426

High

124938

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.316

High

966196

NC2B
Protein Dr1

1

0

High-throughput

0.268

Low

1327023

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.268

Low

166307

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

819596

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.249

Low

1239730

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1242006

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.249

Low

1252203

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1297637

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

1298668

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

1326993

ANLN
Anillin

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024