Protein: SYIM
Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)

Gene: SYIM, IARS2
Organism: Homo sapiens
Interactions: 226
UniProt ID: Q9NSE4

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004822 - isoleucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

325418

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

6

High-throughput

0.643

High

374948

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

5

High-throughput

0.633

High

161721

GAK
Cyclin-G-associated kinase

2

3

High-throughput

0.628

High

258808

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

1

High-throughput

0.628

High

855326

STAT2
Signal transducer and activator of transcription 2

2

1

High-throughput

0.628

High

872717

EPHA4
Ephrin type-A receptor 4

2

4

High-throughput

0.628

High

1056818

ESPL1
Separin

2

1

High-throughput

0.628

High

1219042

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.628

High

1156330

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

0

High-throughput

0.602

High

1187951

RM21
Large ribosomal subunit protein bL21m

2

0

High-throughput

0.602

High

1220294

DHX40
Probable ATP-dependent RNA helicase DHX40

2

0

High-throughput

0.602

High

1242012

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

0

High-throughput

0.602

High

1244844

BBS1
Bardet-Biedl syndrome 1 protein

2

0

High-throughput

0.602

High

1291065

DDX11
ATP-dependent DNA helicase DDX11

2

0

High-throughput

0.602

High

1332864

ASB8
Ankyrin repeat and SOCS box protein 8

2

0

High-throughput

0.602

High

1344294

MBNL1
Muscleblind-like protein 1

2

0

High-throughput

0.602

High

1345561

MTO1
Protein MTO1 homolog, mitochondrial

2

0

High-throughput

0.602

High

1312723

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.585

High

228832

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

262990

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

525653

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

1

High-throughput

0.584

High

1018080

GRSF1
G-rich sequence factor 1

2

3

High-throughput

0.584

High

1086815

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

1334163

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

1224803

ASPM
Abnormal spindle-like microcephaly-associated protein

2

2

High-throughput

0.574

High

1062278

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

6

Small-scale

0.571

High

204065

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.554

High

1297474

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.554

High

388749

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

121537

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.536

High

201985

WDR62
WD repeat-containing protein 62

1

3

High-throughput

0.536

High

339034

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.536

High

438559

HS90B
Heat shock protein HSP 90-beta

1

9

Small-scale

0.536

High

815452

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

984666

CALD1
Caldesmon

1

3

High-throughput

0.536

High

1072610

EPHA7
Ephrin type-A receptor 7

1

4

High-throughput

0.536

High

1079166

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

1345562

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

147563

SOCS6
Suppressor of cytokine signaling 6

1

4

High-throughput

0.515

High

243630

DNJA2
DnaJ homolog subfamily A member 2

1

4

High-throughput

0.515

High

1287994

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.515

High

1290513

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.515

High

176646

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.513

High

275293

RNH2A
Ribonuclease H2 subunit A

1

0

High-throughput

0.513

High

344020

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

536554

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

725039

MYH9
Myosin-9

1

0

High-throughput

0.513

High

846714

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

High-throughput

0.513

High

1289705

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1304020

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1309241

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.513

High

1316971

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

1318332

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

1327963

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

1345557

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.513

High

1302857

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.506

High

395877

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

647315

1433T
14-3-3 protein theta

1

5

High-throughput

0.501

High

976520

ERCC6
DNA excision repair protein ERCC-6

1

3

High-throughput

0.501

High

208947

FOXS1
Forkhead box protein S1

1

14

High-throughput

0.489

High

1335306

IF122
Intraflagellar transport protein 122 homolog

1

3

High-throughput

0.489

High

1345554

HSFX1
Heat shock transcription factor, X-linked

1

2

High-throughput

0.489

High

59324

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

63464

MET15
12S rRNA N4-methylcytidine

1

1

High-throughput

0.479

High

173125

RT12
Small ribosomal subunit protein uS12m

1

2

High-throughput

0.479

High

265054

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

270134

RF1M
Peptide chain release factor 1, mitochondrial

1

6

High-throughput

0.479

High

298825

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

327579

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

2

High-throughput

0.479

High

336898

OTC
Ornithine transcarbamylase, mitochondrial

1

3

High-throughput

0.479

High

385584

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

387595

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

432295

HS90A
Heat shock protein HSP 90-alpha

1

9

Small-scale

0.479

High

440756

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

486652

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

500146

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

535581

GFAP
Glial fibrillary acidic protein

1

2

High-throughput

0.479

High

609566

FGFR3
Fibroblast growth factor receptor 3

1

14

High-throughput

0.479

High

675238

CLIP1
CAP-Gly domain-containing linker protein 1

1

3

High-throughput

0.479

High

737506

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

751852

GRP75
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

777761

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

780174

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

790026

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

799380

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

803249

IF2M
Translation initiation factor IF-2, mitochondrial

1

8

High-throughput

0.479

High

827621

EFTU
Elongation factor Tu, mitochondrial

1

10

High-throughput

0.479

High

836024

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

874250

DRG2
Developmentally-regulated GTP-binding protein 2

1

4

High-throughput

0.479

High

896834

ARP3
Actin-related protein 3

1

2

High-throughput

0.479

High

921745

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

951385

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

959065

TFAM
Transcription factor A, mitochondrial

1

2

High-throughput

0.479

High

981450

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

990344

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

994521

QOR
Quinone oxidoreductase

1

2

High-throughput

0.479

High

1014522

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1020583

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

1035015

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

4

High-throughput

0.479

High

1343667

ANLN
Anillin

1

2

High-throughput

0.479

High

1036123

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1042633

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1045881

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1051110

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

1066757

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1068096

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1072834

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.479

High

1074657

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1128267

SYAM
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

1152982

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1157986

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

1163879

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.479

High

1183236

COX15
Heme A synthase COX15

1

2

High-throughput

0.479

High

1185385

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

6

High-throughput

0.479

High

1200692

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1238971

POC5
Centrosomal protein POC5

1

1

High-throughput

0.479

High

1242998

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.479

High

1282277

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

6

High-throughput

0.479

High

1282855

FAKD4
FAST kinase domain-containing protein 4

1

6

High-throughput

0.479

High

1284534

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

1285771

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1286245

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

1286712

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

1286865

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

1288506

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

1289008

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1289144

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

1300399

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1301160

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

1305111

DNJC7
DnaJ homolog subfamily C member 7

1

3

High-throughput

0.479

High

1305283

PHB2
Prohibitin-2

1

4

High-throughput

0.479

High

1310174

LZTS2
Leucine zipper putative tumor suppressor 2

1

3

High-throughput

0.479

High

1311191

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1311739

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.479

High

1314215

TR61B
tRNA

1

1

High-throughput

0.479

High

1315034

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

1315511

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1317144

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1326528

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1326597

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

1327250

CLPB
Mitochondrial disaggregase

1

6

High-throughput

0.479

High

1329490

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1329811

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1330101

MTRFR
Mitochondrial translation release factor in rescue

1

6

High-throughput

0.479

High

1331134

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

1333102

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1333370

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

1342666

NGRN
Neugrin

1

1

High-throughput

0.479

High

1345545

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

1345547

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

2

High-throughput

0.479

High

1345548

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

1345549

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

1345552

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

6

High-throughput

0.479

High

1345553

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1345555

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

6

High-throughput

0.479

High

1345556

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1345563

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

446808

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.470

High

1345565

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.470

High

276893

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

296768

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.458

High

567293

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

913138

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

949178

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1036931

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1039335

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1101323

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1184058

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

1240323

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1266570

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

1268940

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1294351

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1313509

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

1344089

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1345564

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

1130637

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1145947

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.445

High

1345546

ATD3A
ATPase family AAA domain-containing protein 3A

1

3

High-throughput

0.445

High

1345560

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

1345566

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

47877

RBM47
RNA-binding protein 47

1

1

High-throughput

0.437

High

329968

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

354576

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

553832

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

652368

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

721560

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

781996

PERI
Peripherin

1

2

High-throughput

0.437

High

881682

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

993348

FOXM1
Forkhead box protein M1

1

15

High-throughput

0.437

High

1029925

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.437

High

1080389

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1103028

SMU1
WD40 repeat-containing protein SMU1

1

7

High-throughput

0.437

High

1158866

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.437

High

1171899

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1202465

HOOK3
Protein Hook homolog 3

1

2

High-throughput

0.437

High

1233618

ARL14
ADP-ribosylation factor-like protein 14

1

1

High-throughput

0.437

High

1237799

ARL10
ADP-ribosylation factor-like protein 10

1

1

High-throughput

0.437

High

1297260

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

5

High-throughput

0.437

High

1311333

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.437

High

1313072

DERL1
Derlin-1

1

1

High-throughput

0.437

High

1318808

UNK
RING finger protein unkempt homolog

1

1

High-throughput

0.437

High

1327119

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

1331399

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1342241

DNJC4
DnaJ homolog subfamily C member 4

1

6

High-throughput

0.437

High

1344490

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.437

High

1345558

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.437

High

1295603

NEUL4
Neuralized-like protein 4

1

1

High-throughput

0.407

High

1318864

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

1205559

TMM25
Transmembrane protein 25

3

0

High-throughput

0.347

High

885907

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.328

High

1236638

CELF5
CUGBP Elav-like family member 5

2

0

High-throughput

0.328

High

173526

RER1
Protein RER1

1

0

High-throughput

0.279

Low

1190572

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1285078

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.279

Low

1309934

LSMD1
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.279

Low

1345544

KLC4
Kinesin light chain 4

1

0

High-throughput

0.279

Low

1345551

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.279

Low

1345550

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.269

Low

157663

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.249

Low

279731

FLOT1
Flotillin-1

1

0

High-throughput

0.249

Low

352273

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1152131

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1289303

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.249

Low

1300793

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1335481

PLRKT
Plasminogen receptor

1

0

High-throughput

0.249

Low

1345559

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024