Protein: PTN21
Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)

Gene: PTN21, PTPN21
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q16825

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1087943

RASD1
Dexamethasone-induced Ras-related protein 1

2

15

High-throughput

0.783

High

850743

BMX
Cytoplasmic tyrosine-protein kinase BMX

3

20

Small-scale

0.780

High

1087894

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

19

High-throughput

0.757

High

523010

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.754

High

904617

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

1076408

TRIP6
Thyroid receptor-interacting protein 6

3

18

High-throughput

0.656

High

1087910

KIBRA
Protein KIBRA

3

20

High-throughput

0.650

High

1070971

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

Small-scale

0.648

High

1087931

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

3

12

Small-scale

0.640

High

808660

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.624

High

1087899

WWC2
Protein WWC2

2

20

High-throughput

0.611

High

1087930

PAR6B
Partitioning defective 6 homolog beta

3

15

High-throughput

0.609

High

324429

BAG3
BAG family molecular chaperone regulator 3

2

3

High-throughput

0.606

High

1049053

TRI14
Tripartite motif-containing protein 14

2

9

High-throughput

0.606

High

1087906

MOB3C
MOB kinase activator 3C

2

11

High-throughput

0.606

High

1087917

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

20

High-throughput

0.606

High

1087922

FBX17
F-box only protein 17

2

8

High-throughput

0.606

High

1087935

NEK6
Serine/threonine-protein kinase Nek6

2

15

High-throughput

0.606

High

1087940

PAK5
Serine/threonine-protein kinase PAK 5

2

13

High-throughput

0.606

High

216933

KIF1C
Kinesin-like protein KIF1C

2

17

Small-scale

0.587

High

574361

RL35A
Large ribosomal subunit protein eL33

2

2

High-throughput

0.584

High

1087909

ARMC8
Armadillo repeat-containing protein 8

2

2

High-throughput

0.584

High

1087932

WDR26
WD repeat-containing protein 26

2

17

High-throughput

0.584

High

814462

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.580

High

1087903

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

2

0

High-throughput

0.580

High

1087913

RHPN1
Rhophilin-1

2

15

High-throughput

0.574

High

1087925

AJUBA
LIM domain-containing protein ajuba

2

18

High-throughput

0.574

High

1087920

LPP
Lipoma-preferred partner

2

19

High-throughput

0.558

High

994904

GOGA2
Golgin subfamily A member 2

2

11

High-throughput

0.553

High

1087912

CTSR1
Cation channel sperm-associated protein 1

2

13

High-throughput

0.553

High

1087921

MGN2
Protein mago nashi homolog 2

2

1

High-throughput

0.553

High

1087928

SNX18
Sorting nexin-18

2

2

High-throughput

0.553

High

1087936

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

7

High-throughput

0.553

High

1087937

PAR6A
Partitioning defective 6 homolog alpha

2

20

High-throughput

0.553

High

683381

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

901675

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.536

High

909614

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.536

High

927093

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

982052

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1087919

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

High-throughput

0.536

High

586782

CSK22
Casein kinase II subunit alpha'

2

9

High-throughput

0.533

High

934204

CSK21
Casein kinase II subunit alpha

2

13

High-throughput

0.533

High

171625

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.513

High

1087938

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.513

High

1087918

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

204497

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

1

High-throughput

0.479

High

216516

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

8

High-throughput

0.479

High

255827

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

515448

CDK4
Cyclin-dependent kinase 4

1

8

High-throughput

0.479

High

760091

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

806029

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

806542

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.479

High

951579

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.479

High

1087895

DUS7
Dual specificity protein phosphatase 7

1

7

High-throughput

0.479

High

1087897

AMOT
Angiomotin

1

20

High-throughput

0.479

High

1087898

DCAF8
DDB1- and CUL4-associated factor 8

1

12

High-throughput

0.479

High

1087900

ELP2
Elongator complex protein 2

1

3

High-throughput

0.479

High

1087902

RBP10
Ran-binding protein 10

1

7

High-throughput

0.479

High

1087908

MAEA
E3 ubiquitin-protein transferase MAEA

1

10

High-throughput

0.479

High

1087916

NEK7
Serine/threonine-protein kinase Nek7

1

17

High-throughput

0.479

High

1087924

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

3

High-throughput

0.479

High

1087927

DCAF5
DDB1- and CUL4-associated factor 5

1

14

High-throughput

0.479

High

1087929

RANB9
Ran-binding protein 9

1

8

High-throughput

0.479

High

1087933

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

8

High-throughput

0.479

High

1087939

GID8
Glucose-induced degradation protein 8 homolog

1

10

High-throughput

0.479

High

1087896

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

169859

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

215636

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.458

High

1087945

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.458

High

312284

IPO7
Importin-7

1

15

High-throughput

0.437

High

903265

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

1087901

CEP85
Centrosomal protein of 85 kDa

1

18

High-throughput

0.437

High

1087905

STXB4
Syntaxin-binding protein 4

1

20

High-throughput

0.437

High

1087914

DDX54
ATP-dependent RNA helicase DDX54

1

7

High-throughput

0.437

High

1087915

BPIB1
BPI fold-containing family B member 1

1

3

High-throughput

0.437

High

1087923

SAHH3
Adenosylhomocysteinase 3

1

8

High-throughput

0.437

High

1087926

TMX3
Protein disulfide-isomerase TMX3

1

13

High-throughput

0.437

High

1087941

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.437

High

1087942

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

161206

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.316

High

1087904

ZN497
Zinc finger protein 497

2

0

High-throughput

0.316

High

1087907

ATOSB
Atos homolog protein B

2

0

High-throughput

0.316

High

47929

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.249

Low

882888

NRG3
Pro-neuregulin-3, membrane-bound isoform

1

0

Small-scale

0.249

Low

1087648

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.249

Low

1087911

P20D2
Xaa-Arg dipeptidase

1

0

High-throughput

0.249

Low

1087934

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.249

Low

1087944

IFT52
Intraflagellar transport protein 52 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024