Protein: DRA
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)

Gene: DRA, HLA-DRA
Organism: Homo sapiens
Interactions: 168
UniProt ID: P01903

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001772 - immunological synapse
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002250 - adaptive immune response
GO:0002469 - myeloid dendritic cell antigen processing and presentation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

354676

DMB
HLA class II histocompatibility antigen, DM beta chain

4

18

Small-scale

0.895

High

354706

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

3

18

High-throughput

0.861

High

354652

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

3

18

Small-scale

0.834

High

354677

EPHA3
Ephrin type-A receptor 3

2

11

High-throughput

0.789

High

354686

EPHB4
Ephrin type-B receptor 4

2

12

High-throughput

0.789

High

354745

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

2

5

High-throughput

0.789

High

354779

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

2

5

High-throughput

0.789

High

354675

DMA
HLA class II histocompatibility antigen, DM alpha chain

2

18

Small-scale

0.767

High

179921

TLR3
Toll-like receptor 3

1

4

Small-scale

0.724

High

354797

KLK4
Kallikrein-4

2

12

High-throughput

0.705

High

354651

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

19

High-throughput

0.691

High

354653

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

20

High-throughput

0.691

High

354660

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.691

High

354670

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

18

High-throughput

0.691

High

354672

EPHA1
Ephrin type-A receptor 1

1

12

High-throughput

0.691

High

354691

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

18

High-throughput

0.691

High

354721

TM11B
Transmembrane protease serine 11B

1

10

High-throughput

0.691

High

354737

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

3

High-throughput

0.691

High

354786

BTNL2
Butyrophilin-like protein 2

1

11

High-throughput

0.691

High

354734

SCRB1
Scavenger receptor class B member 1

3

4

High-throughput

0.667

High

354759

CNTP3
Contactin-associated protein-like 3

3

4

High-throughput

0.667

High

354785

LCAP
Leucyl-cystinyl aminopeptidase

3

8

High-throughput

0.667

High

354655

C1QB
Complement C1q subcomponent subunit B

1

2

High-throughput

0.618

High

237451

TLR2
Toll-like receptor 2

1

5

Small-scale

0.618

High

354678

C2TA
MHC class II transactivator

1

2

Small-scale

0.618

High

354756

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

6

High-throughput

0.618

High

354656

HG2A
HLA class II histocompatibility antigen gamma chain

2

9

Small-scale

0.611

High

354682

MA2A2
Alpha-mannosidase 2x

2

3

High-throughput

0.611

High

354753

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

2

11

High-throughput

0.611

High

354767

PACC1
Proton-activated chloride channel

2

1

High-throughput

0.611

High

354773

CHSTC
Carbohydrate sulfotransferase 12

2

9

High-throughput

0.611

High

354777

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

2

1

High-throughput

0.611

High

354793

DD19B
ATP-dependent RNA helicase DDX19B

2

1

High-throughput

0.611

High

354780

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

3

9

High-throughput

0.609

High

354733

MARH1
E3 ubiquitin-protein ligase MARCHF1

2

1

Small-scale

0.595

High

354708

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.585

High

354654

MBP
Myelin basic protein

1

1

Small-scale

0.575

High

354669

GDC
Solute carrier family 25 member 16

2

11

High-throughput

0.558

High

354729

NETO2
Neuropilin and tolloid-like protein 2

2

5

High-throughput

0.558

High

354743

TECT2
Tectonic-2

2

6

High-throughput

0.558

High

354790

POMT2
Protein O-mannosyl-transferase 2

2

2

High-throughput

0.558

High

245470

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.536

High

260213

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

5

High-throughput

0.536

High

274893

RENR
Renin receptor

1

2

High-throughput

0.536

High

318335

ECEL1
Endothelin-converting enzyme-like 1

1

7

High-throughput

0.536

High

354665

ADT1
ADP/ATP translocase 1

1

8

High-throughput

0.536

High

354666

PERF
Perforin-1

1

1

High-throughput

0.536

High

354679

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

2

High-throughput

0.536

High

354680

SCNNA
Amiloride-sensitive sodium channel subunit alpha

1

12

High-throughput

0.536

High

354690

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.536

High

354694

NUCB1
Nucleobindin-1

1

2

High-throughput

0.536

High

354695

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

9

High-throughput

0.536

High

354697

S39A6
Zinc transporter ZIP6

1

7

High-throughput

0.536

High

354699

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

9

High-throughput

0.536

High

354701

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

4

High-throughput

0.536

High

354703

SGCB
Beta-sarcoglycan

1

2

High-throughput

0.536

High

354705

T132A
Transmembrane protein 132A

1

1

High-throughput

0.536

High

354707

ZACN
Ligand-gated cation channel ZACN

1

6

High-throughput

0.536

High

354712

AGRF1
Adhesion G-protein coupled receptor F1

1

5

High-throughput

0.536

High

354716

CNNM4
Metal transporter CNNM4

1

9

High-throughput

0.536

High

354719

CHST9
Carbohydrate sulfotransferase 9

1

9

High-throughput

0.536

High

354720

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

9

High-throughput

0.536

High

354726

ABD12
Lysophosphatidylserine lipase ABHD12

1

3

High-throughput

0.536

High

354730

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

1

8

High-throughput

0.536

High

354731

CNNM3
Metal transporter CNNM3

1

9

High-throughput

0.536

High

354736

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

3

High-throughput

0.536

High

354760

ABCA2
ATP-binding cassette sub-family A member 2

1

5

High-throughput

0.536

High

354762

CHST8
Carbohydrate sulfotransferase 8

1

9

High-throughput

0.536

High

354763

SEM6A
Semaphorin-6A

1

11

High-throughput

0.536

High

354764

SEM6B
Semaphorin-6B

1

10

High-throughput

0.536

High

354765

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

8

High-throughput

0.536

High

354770

AT132
Polyamine-transporting ATPase 13A2

1

16

High-throughput

0.536

High

354771

ITM2C
Integral membrane protein 2C

1

8

High-throughput

0.536

High

354775

CNNM1
Metal transporter CNNM1

1

9

High-throughput

0.536

High

354776

SEM4G
Semaphorin-4G

1

11

High-throughput

0.536

High

354778

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

5

High-throughput

0.536

High

354788

TM59L
Transmembrane protein 59-like

1

2

High-throughput

0.536

High

354789

TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

1

8

High-throughput

0.536

High

354791

DSE
Dermatan-sulfate epimerase

1

2

High-throughput

0.536

High

354792

S39AA
Zinc transporter ZIP10

1

7

High-throughput

0.536

High

354794

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

1

8

High-throughput

0.536

High

354798

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

5

High-throughput

0.536

High

354799

AGRG1
Adhesion G-protein coupled receptor G1

1

5

High-throughput

0.536

High

230109

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.513

High

276353

AP1G2
AP-1 complex subunit gamma-like 2

1

0

High-throughput

0.513

High

300654

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.513

High

352908

IFNG
Interferon gamma

1

0

High-throughput

0.513

High

354658

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.513

High

354684

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

354696

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

354717

KCIP4
Kv channel-interacting protein 4

1

0

High-throughput

0.513

High

354728

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

354742

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.513

High

354688

WDR4
tRNA

1

2

High-throughput

0.494

High

49118

TM223
Transmembrane protein 223

1

2

High-throughput

0.489

High

215720

GTPB6
Putative GTP-binding protein 6

1

2

High-throughput

0.489

High

305293

NXPH4
Neurexophilin-4

1

1

High-throughput

0.489

High

354673

COT2
COUP transcription factor 2

1

2

High-throughput

0.489

High

354685

NEK4
Serine/threonine-protein kinase Nek4

1

4

High-throughput

0.489

High

354687

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

3

High-throughput

0.489

High

354692

SSBP2
Single-stranded DNA-binding protein 2

1

3

High-throughput

0.489

High

354704

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

5

High-throughput

0.489

High

354709

MKS3
Meckelin

1

5

High-throughput

0.489

High

354710

TGO1
Transport and Golgi organization protein 1 homolog

1

2

High-throughput

0.489

High

354711

KMCP1
Kidney mitochondrial carrier protein 1

1

8

High-throughput

0.489

High

354713

MYORG
Myogenesis-regulating glycosidase

1

4

High-throughput

0.489

High

354714

TM214
Transmembrane protein 214

1

2

High-throughput

0.489

High

354722

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

12

High-throughput

0.489

High

354723

S2542
Mitochondrial coenzyme A transporter SLC25A42

1

11

High-throughput

0.489

High

354727

S2529
Mitochondrial basic amino acids transporter

1

11

High-throughput

0.489

High

354732

S2540
Mitochondrial glutathione transporter SLC25A40

1

13

High-throughput

0.489

High

354739

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.489

High

354740

TTC28
Tetratricopeptide repeat protein 28

1

2

High-throughput

0.489

High

354741

SARAF
Store-operated calcium entry-associated regulatory factor

1

4

High-throughput

0.489

High

354744

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.489

High

354747

FACR2
Fatty acyl-CoA reductase 2

1

1

High-throughput

0.489

High

354748

CLP1L
Lipid scramblase CLPTM1L

1

1

High-throughput

0.489

High

354749

SFXN2
Sideroflexin-2

1

4

High-throughput

0.489

High

354750

F210A
Protein FAM210A

1

1

High-throughput

0.489

High

354755

S2533
Solute carrier family 25 member 33

1

10

High-throughput

0.489

High

354757

T106C
Transmembrane protein 106C

1

15

High-throughput

0.489

High

354758

SFXN3
Sideroflexin-3

1

4

High-throughput

0.489

High

354766

MTG2
Mitochondrial ribosome-associated GTPase 2

1

3

High-throughput

0.489

High

354769

S38AA
Solute carrier family 38 member 10

1

5

High-throughput

0.489

High

354772

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.489

High

354774

D39U1
Epimerase family protein SDR39U1

1

2

High-throughput

0.489

High

354781

EXTL2
Exostosin-like 2

1

6

High-throughput

0.489

High

354782

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.489

High

354784

SE1L1
Protein sel-1 homolog 1

1

2

High-throughput

0.489

High

354796

RN115
E3 ubiquitin-protein ligase RNF115

1

6

High-throughput

0.489

High

58778

T131L
Transmembrane protein 131-like

1

7

High-throughput

0.479

High

354657

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

8

Small-scale

0.479

High

354659

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

354661

HS90B
Heat shock protein HSP 90-beta

1

7

Small-scale

0.479

High

354662

CD63
CD63 antigen

1

8

Small-scale

0.479

High

354663

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

354664

CD20
B-lymphocyte antigen CD20

1

3

Small-scale

0.479

High

354667

KPYM
Pyruvate kinase PKM

1

3

Small-scale

0.479

High

354674

CD82
CD82 antigen

1

8

Small-scale

0.479

High

354683

ANX11
Annexin A11

1

4

Small-scale

0.479

High

354689

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

354693

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

1

High-throughput

0.479

High

354700

STIM1
Stromal interaction molecule 1

1

3

High-throughput

0.479

High

354761

TOLIP
Toll-interacting protein

1

1

Small-scale

0.479

High

354787

PLXA1
Plexin-A1

1

11

High-throughput

0.479

High

258365

TM127
Transmembrane protein 127

1

0

Small-scale

0.458

High

354768

PKHA2
Pleckstrin homology domain-containing family A member 2

1

0

Small-scale

0.458

High

354718

BRWD3
Bromodomain and WD repeat-containing protein 3

1

2

High-throughput

0.437

High

354751

CNT3B
Contactin-associated protein-like 3B

1

4

High-throughput

0.407

High

354752

MIA2
Melanoma inhibitory activity protein 2

1

3

High-throughput

0.407

High

64408

RTL8C
Retrotransposon Gag-like protein 8C

1

0

High-throughput

0.279

Low

224259

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.279

Low

266087

ERLN1
Erlin-1

1

0

High-throughput

0.279

Low

323511

CER1
Cerberus

1

0

High-throughput

0.279

Low

354671

TBP
TATA-box-binding protein

1

0

High-throughput

0.279

Low

354698

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

354702

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.279

Low

354715

CC033
Protein C3orf33

1

0

High-throughput

0.279

Low

354724

MICU2
Calcium uptake protein 2, mitochondrial

1

0

High-throughput

0.279

Low

354725

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

354738

NXPE3
NXPE family member 3

1

0

High-throughput

0.279

Low

354746

SRAC1
Protein SERAC1

1

0

High-throughput

0.279

Low

354754

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

354783

FA8A1
Protein FAM8A1

1

0

High-throughput

0.279

Low

354795

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

354735

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.269

Low

354668

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.249

Low

354681

RFX5
DNA-binding protein RFX5

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024