Protein: NEP
Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10)

Gene: NEP, MME
Organism: Homo sapiens
Interactions: 135
UniProt ID: P08473

Gene Ontology (top 5):
GO:0001786 - phosphatidylserine binding
GO:0001822 - kidney development
GO:0001890 - placenta development
GO:0004175 - endopeptidase activity
GO:0004222 - metalloendopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439793

EPHB4
Ephrin type-B receptor 4

2

2

High-throughput

0.628

High

439843

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

2

1

High-throughput

0.628

High

439871

TEN3
Teneurin-3

2

3

High-throughput

0.628

High

439874

MAN1
Inner nuclear membrane protein Man1

2

2

High-throughput

0.628

High

234768

ACSL4
Long-chain-fatty-acid--CoA ligase 4

2

0

High-throughput

0.602

High

439775

B4GT1
Beta-1,4-galactosyltransferase 1

2

0

High-throughput

0.602

High

439810

NTCP7
Sodium/bile acid cotransporter 7

2

0

High-throughput

0.602

High

439815

STAR3
StAR-related lipid transfer protein 3

2

0

High-throughput

0.602

High

439855

PXL2A
Peroxiredoxin-like 2A

2

0

High-throughput

0.602

High

439859

GL8D2
Glycosyltransferase 8 domain-containing protein 2

2

0

High-throughput

0.602

High

439867

PXMP2
Peroxisomal membrane protein 2

2

0

High-throughput

0.602

High

433527

LYN
Tyrosine-protein kinase Lyn

2

0

Small-scale

0.598

High

439803

CSK21
Casein kinase II subunit alpha

2

0

Small-scale

0.592

High

439765

NEP
Neprilysin

1

1

Small-scale

0.575

High

439826

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

1

High-throughput

0.574

High

439797

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

0

Small-scale

0.569

High

439780

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

1

High-throughput

0.536

High

439785

ARL1
ADP-ribosylation factor-like protein 1

1

1

Small-scale

0.536

High

439791

MOT1
Monocarboxylate transporter 1

1

1

Small-scale

0.536

High

439798

RAP2B
Ras-related protein Rap-2b

1

2

Small-scale

0.536

High

439820

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

Small-scale

0.536

High

439827

LTOR1
Ragulator complex protein LAMTOR1

1

1

Small-scale

0.536

High

439831

GALT7
N-acetylgalactosaminyltransferase 7

1

2

High-throughput

0.536

High

439841

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.536

High

439848

S22AI
Solute carrier family 22 member 18

1

6

High-throughput

0.536

High

439856

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

439861

CLC4M
C-type lectin domain family 4 member M

1

3

Small-scale

0.536

High

439870

DJB12
DnaJ homolog subfamily B member 12

1

4

Small-scale

0.536

High

439872

RUVB2
RuvB-like 2

1

1

Small-scale

0.536

High

439873

RUVB1
RuvB-like 1

1

1

Small-scale

0.536

High

153860

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

Small-scale

0.513

High

175554

TM9S1
Transmembrane 9 superfamily member 1

1

0

Small-scale

0.513

High

197878

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

0

Small-scale

0.513

High

231046

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.513

High

276412

FACE1
CAAX prenyl protease 1 homolog

1

0

Small-scale

0.513

High

311195

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

Small-scale

0.513

High

388162

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.513

High

439766

H2A1
Histone H2A type 1

1

0

Small-scale

0.513

High

439769

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.513

High

439770

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.513

High

439771

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.513

High

439772

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.513

High

439773

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.513

High

439774

K1C10
Keratin, type I cytoskeletal 10

1

0

Small-scale

0.513

High

439779

HEMH
Ferrochelatase, mitochondrial

1

0

Small-scale

0.513

High

439782

MYH9
Myosin-9

1

0

Small-scale

0.513

High

439783

ADDB
Beta-adducin

1

0

High-throughput

0.513

High

439784

LONM
Lon protease homolog, mitochondrial

1

0

Small-scale

0.513

High

439786

VDAC2
Voltage-dependent anion-selective channel protein 2

1

0

Small-scale

0.513

High

439787

RS10
Small ribosomal subunit protein eS10

1

0

Small-scale

0.513

High

439788

UTRN
Utrophin

1

0

Small-scale

0.513

High

439789

SSRD
Translocon-associated protein subunit delta

1

0

Small-scale

0.513

High

439790

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

Small-scale

0.513

High

439792

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

Small-scale

0.513

High

439799

RS23
Small ribosomal subunit protein uS12

1

0

Small-scale

0.513

High

439801

RL30
Large ribosomal subunit protein eL30

1

0

Small-scale

0.513

High

439802

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.513

High

439806

FOLH1
Glutamate carboxypeptidase 2

1

0

Small-scale

0.513

High

439811

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

Small-scale

0.513

High

439812

FLOT2
Flotillin-2

1

0

Small-scale

0.513

High

439816

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

Small-scale

0.513

High

439822

TBB8
Tubulin beta-8 chain

1

0

Small-scale

0.513

High

439825

TM164
Transmembrane protein 164

1

0

High-throughput

0.513

High

439833

LYRIC
Protein LYRIC

1

0

Small-scale

0.513

High

439834

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.513

High

439842

FA83F
Protein FAM83F

1

0

Small-scale

0.513

High

439846

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

0

Small-scale

0.513

High

439847

TNPO1
Transportin-1

1

0

Small-scale

0.513

High

439849

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

Small-scale

0.513

High

439851

PIGS
GPI transamidase component PIG-S

1

0

High-throughput

0.513

High

439854

CAB45
45 kDa calcium-binding protein

1

0

Small-scale

0.513

High

439857

HDAC8
Histone deacetylase 8

1

0

High-throughput

0.513

High

439858

F234A
Protein FAM234A

1

0

Small-scale

0.513

High

439860

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

Small-scale

0.513

High

439862

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

439863

TMT1A
Thiol S-methyltransferase TMT1A

1

0

Small-scale

0.513

High

439865

RM44
Large ribosomal subunit protein mL44

1

0

Small-scale

0.513

High

344359

ANGT
Angiotensinogen

1

2

Small-scale

0.501

High

439776

EZRI
Ezrin

1

1

Small-scale

0.501

High

439778

CD9
CD9 antigen

1

8

Small-scale

0.500

High

439844

NDRG1
Protein NDRG1

1

0

Small-scale

0.493

High

439868

SNRK
SNF-related serine/threonine-protein kinase

1

0

High-throughput

0.493

High

393962

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

439809

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.493

High

439813

RBM39
RNA-binding protein 39

1

1

Small-scale

0.489

High

439814

PDIA5
Protein disulfide-isomerase A5

1

1

Small-scale

0.489

High

439824

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

1

High-throughput

0.489

High

351512

ANF
Natriuretic peptides A

1

0

Small-scale

0.480

High

439767

POTEI
POTE ankyrin domain family member I

1

1

Small-scale

0.479

High

439768

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

439781

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

439795

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.479

High

439800

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

439807

FAK1
Focal adhesion kinase 1

1

1

Small-scale

0.479

High

439818

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

439819

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

439830

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

439836

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

439845

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

439817

T132D
Transmembrane protein 132D

1

0

Small-scale

0.460

High

353244

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

439805

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

439823

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

439838

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

439852

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

Small-scale

0.458

High

439864

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

354923

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

9

Small-scale

0.445

High

382271

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.445

High

439777

IGLL1
Immunoglobulin lambda-like polypeptide 1

1

3

Small-scale

0.445

High

439796

CD81
CD81 antigen

1

8

Small-scale

0.445

High

439837

CD177
CD177 antigen

1

1

Small-scale

0.445

High

436057

ANXA6
Annexin A6

1

0

Small-scale

0.426

High

439876

DAAM1
Disheveled-associated activator of morphogenesis 1

1

0

Small-scale

0.426

High

439829

POTEH
POTE ankyrin domain family member H

1

1

Small-scale

0.407

High

49121

TM223
Transmembrane protein 223

2

0

High-throughput

0.328

High

131801

FAAH1
Fatty-acid amide hydrolase 1

1

0

Small-scale

0.279

Low

306449

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

Small-scale

0.279

Low

359582

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.279

Low

439794

ATPK
ATP synthase subunit f, mitochondrial

1

0

Small-scale

0.279

Low

439804

RT25
Small ribosomal subunit protein mS25

1

0

Small-scale

0.279

Low

439808

SRS11
Serine/arginine-rich splicing factor 11

1

0

Small-scale

0.279

Low

439821

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

Small-scale

0.279

Low

439828

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

Small-scale

0.279

Low

439835

ARM10
Armadillo repeat-containing protein 10

1

0

Small-scale

0.279

Low

439839

KBTB3
Kelch repeat and BTB domain-containing protein 3

1

0

Small-scale

0.279

Low

439840

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

Small-scale

0.279

Low

439875

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.279

Low

439877

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

Small-scale

0.279

Low

100403

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

439866

ANLN
Anillin

1

0

High-throughput

0.249

Low

439832

NOP9
Nucleolar protein 9

1

0

Small-scale

0.232

Low

439850

GUCD1
Protein GUCD1

1

0

Small-scale

0.232

Low

439853

CMS1
Protein CMSS1

1

0

Small-scale

0.232

Low

439869

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024