Protein: PEO1
Twinkle mtDNA helicase (EC 5.6.2.3) (Progressive external ophthalmoplegia 1 protein) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Twinkle protein, mitochondrial)

Gene: PEO1, TWNK
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q96RR1

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0003678 - DNA helicase activity
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1297507

PRIPO
DNA-directed primase/polymerase protein

2

0

High-throughput

0.602

High

1051049

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

161867

ZN263
Zinc finger protein 263

2

1

High-throughput

0.574

High

262925

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

449799

HMGB1
High mobility group protein B1

1

2

High-throughput

0.536

High

1036828

SQSTM
Sequestosome-1

1

1

High-throughput

0.536

High

370254

ESR1
Estrogen receptor

2

1

High-throughput

0.521

High

537004

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.513

High

942886

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.513

High

1109061

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.513

High

1288617

PABP5
Polyadenylate-binding protein 5

1

0

High-throughput

0.513

High

432874

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.489

High

1084376

SRSF7
Serine/arginine-rich splicing factor 7

1

1

High-throughput

0.489

High

476239

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

265001

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

270098

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

803199

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

827536

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

959012

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

981383

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1014463

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1128218

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1269417

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1282256

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

1301107

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

1301320

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1301335

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

59270

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

63427

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.458

High

173089

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

327529

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

440680

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

486612

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

777687

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

789936

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

799327

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

990255

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1045832

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1086741

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1135832

DCAF8
DDB1- and CUL4-associated factor 8

1

0

High-throughput

0.458

High

1218919

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

1282796

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1285733

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1286832

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1287970

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.458

High

1288494

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1288964

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1289092

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1300372

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1301311

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1301314

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1301315

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1301317

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1301318

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1301321

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1301323

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1301324

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1301328

NGRN
Neugrin

1

0

High-throughput

0.458

High

1301330

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1301333

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1301340

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

435158

SP1
Transcription factor Sp1

1

1

High-throughput

0.457

High

1301316

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

171435

SMAD9
Mothers against decapentaplegic homolog 9

1

1

High-throughput

0.439

High

451305

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.437

High

1301312

RAD9A
Cell cycle checkpoint control protein RAD9A

1

1

High-throughput

0.437

High

1301339

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

1

Small-scale

0.437

High

387343

P53
Cellular tumor antigen p53

1

0

Small-scale

0.426

High

1044078

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.426

High

99730

F5H4F1
RAD9 checkpoint clamp component A

1

1

High-throughput

0.407

High

110804

H7BYY1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.407

High

303433

HEXI1
Protein HEXIM1

4

0

High-throughput

0.362

High

745273

RBMX
RNA-binding motif protein, X chromosome

3

0

High-throughput

0.347

High

1040394

TRA2A
Transformer-2 protein homolog alpha

3

0

High-throughput

0.347

High

814655

CDX1
Homeobox protein CDX-1

2

0

High-throughput

0.328

High

848108

MECP2
Methyl-CpG-binding protein 2

2

0

High-throughput

0.328

High

1060259

ZN169
Zinc finger protein 169

2

0

High-throughput

0.328

High

1201613

ZCH18
Zinc finger CCCH domain-containing protein 18

2

0

High-throughput

0.328

High

995425

LG3BP
Galectin-3-binding protein

2

0

High-throughput

0.319

High

1153901

IFIX
Pyrin and HIN domain-containing protein 1

2

0

High-throughput

0.318

High

818374

SOX2
Transcription factor SOX-2

2

0

High-throughput

0.310

High

1301325

AKTIP
AKT-interacting protein

1

0

High-throughput

0.282

High

49220

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.279

Low

64496

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.279

Low

316131

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.279

Low

451538

CLCA
Clathrin light chain A

1

0

High-throughput

0.279

Low

612499

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.279

Low

642532

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.279

Low

654036

MAP4
Microtubule-associated protein 4

1

0

High-throughput

0.279

Low

659667

MZF1
Myeloid zinc finger 1

1

0

High-throughput

0.279

Low

736669

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.279

Low

892757

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

0

High-throughput

0.279

Low

982409

1433F
14-3-3 protein eta

1

0

High-throughput

0.279

Low

1029047

SRSF6
Serine/arginine-rich splicing factor 6

1

0

High-throughput

0.279

Low

1052137

MAP7
Ensconsin

1

0

High-throughput

0.279

Low

1148953

CYTSA
Cytospin-A

1

0

High-throughput

0.279

Low

1193020

ZN467
Zinc finger protein 467

1

0

High-throughput

0.279

Low

1197826

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.279

Low

1217308

LYSM2
LysM and putative peptidoglycan-binding domain-containing protein 2

1

0

High-throughput

0.279

Low

1262657

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1264756

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.279

Low

1286399

ZN524
Zinc finger protein 524

1

0

High-throughput

0.279

Low

1301313

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

0

High-throughput

0.279

Low

1301319

FOXP1
Forkhead box protein P1

1

0

High-throughput

0.279

Low

1301322

ACTL8
Actin-like protein 8

1

0

High-throughput

0.279

Low

1301326

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.279

Low

1301327

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.279

Low

1301329

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.279

Low

1301331

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.279

Low

1301334

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.279

Low

1301336

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

1301338

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

679159

TLX1
T-cell leukemia homeobox protein 1

1

0

High-throughput

0.261

Low

985250

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.261

Low

122951

MEN1
Menin

1

0

High-throughput

0.249

Low

210216

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

326756

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.249

Low

591060

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

718125

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.249

Low

951250

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

1255665

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.249

Low

1256345

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1301337

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

902724

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.238

Low

1233158

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

1256720

ARH40
Rho guanine nucleotide exchange factor 40

1

0

High-throughput

0.232

Low

1301332

GRHL1
Grainyhead-like protein 1 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024