Protein: HECD3
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)

Gene: HECD3, HECTD3
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q5T447

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0016567 - protein ubiquitination
GO:0019905 - syntaxin binding
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048471 - perinuclear region of cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

919743

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.845

High

1133272

UBQL1
Ubiquilin-1

1

17

High-throughput

0.665

High

135939

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

20

Small-scale

0.647

High

829013

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

20

Small-scale

0.647

High

895807

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

1086902

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

20

Small-scale

0.647

High

1133215

HECD3
E3 ubiquitin-protein ligase HECTD3

1

16

Small-scale

0.647

High

1133244

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

3

Small-scale

0.647

High

1133249

ODAD4
Outer dynein arm-docking complex subunit 4

1

16

High-throughput

0.618

High

227698

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

803571

BAG6
Large proline-rich protein BAG6

1

20

Small-scale

0.618

High

534250

YJU2B
Probable splicing factor YJU2B

3

1

High-throughput

0.609

High

548308

FOSL2
Fos-related antigen 2

3

4

High-throughput

0.609

High

1101901

RSPO1
R-spondin-1

3

3

High-throughput

0.609

High

1133217

MRM1
rRNA methyltransferase 1, mitochondrial

3

2

High-throughput

0.609

High

1133224

TM10C
tRNA methyltransferase 10 homolog C

3

1

High-throughput

0.609

High

1133257

PAR6B
Partitioning defective 6 homolog beta

3

9

High-throughput

0.609

High

158075

WNT9B
Protein Wnt-9b

3

5

High-throughput

0.599

High

914994

RS4X
Small ribosomal subunit protein eS4, X isoform

3

8

High-throughput

0.593

High

67760

ZBBX
Zinc finger B-box domain-containing protein 1

2

2

High-throughput

0.574

High

168299

ANGP2
Angiopoietin-2

2

2

High-throughput

0.574

High

270872

CLC3A
C-type lectin domain family 3 member A

2

1

High-throughput

0.574

High

352389

GAST
Gastrin [Cleaved into: Gastrin-71

2

1

High-throughput

0.574

High

397661

IPSP
Plasma serine protease inhibitor

2

2

High-throughput

0.574

High

948268

RT34
Small ribosomal subunit protein mS34

2

1

High-throughput

0.574

High

1133219

CAVN1
Caveolae-associated protein 1

2

3

High-throughput

0.574

High

1133220

LYZL1
Lysozyme-like protein 1

2

3

High-throughput

0.574

High

1133226

LYZL2
Lysozyme-like protein 2

2

3

High-throughput

0.574

High

1133228

EGFL6
Epidermal growth factor-like protein 6

2

17

High-throughput

0.574

High

1133231

RBFA
Putative ribosome-binding factor A, mitochondrial

2

1

High-throughput

0.574

High

1133247

RT24
Small ribosomal subunit protein uS3m

2

2

High-throughput

0.574

High

1133253

GA2L1
GAS2-like protein 1

2

8

High-throughput

0.574

High

1133256

CRDL1
Chordin-like protein 1

2

8

High-throughput

0.574

High

1133260

WF10A
WAP four-disulfide core domain protein 10A

2

1

High-throughput

0.574

High

1133264

CSN7B
COP9 signalosome complex subunit 7b

2

7

High-throughput

0.574

High

319225

BRD1
Bromodomain-containing protein 1

2

10

High-throughput

0.558

High

1133236

PGLT1
Protein O-glucosyltransferase 1

2

1

High-throughput

0.558

High

1133237

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

2

1

High-throughput

0.558

High

1133251

ZN317
Zinc finger protein 317

2

7

High-throughput

0.558

High

234231

PEPL
Periplakin

2

20

High-throughput

0.553

High

1133269

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

15

Small-scale

0.552

High

1133261

TARA
TRIO and F-actin-binding protein

1

13

Small-scale

0.523

High

167562

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.512

High

455529

PARP1
Poly [ADP-ribose] polymerase 1

1

10

Small-scale

0.512

High

876986

CASP9
Caspase-9

1

5

Small-scale

0.512

High

1059308

CASP8
Caspase-8

1

5

Small-scale

0.512

High

1133227

ZDH17
Palmitoyltransferase ZDHHC17

1

11

High-throughput

0.494

High

49247

FEZF1
Fez family zinc finger protein 1

1

14

High-throughput

0.489

High

59200

VWA8
von Willebrand factor A domain-containing protein 8

1

4

High-throughput

0.489

High

131780

LAD1
Ladinin-1

1

8

High-throughput

0.489

High

382603

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

6

High-throughput

0.489

High

573298

TCPA
T-complex protein 1 subunit alpha

1

16

High-throughput

0.489

High

588302

FST
Follistatin

1

1

High-throughput

0.489

High

603852

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

8

High-throughput

0.489

High

714667

CNR2
Cannabinoid receptor 2

1

10

Small-scale

0.489

High

726522

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.489

High

770876

TCPZ
T-complex protein 1 subunit zeta

1

19

High-throughput

0.489

High

843235

TCPD
T-complex protein 1 subunit delta

1

18

High-throughput

0.489

High

884317

PCBP3
Poly(rC)-binding protein 3

1

20

High-throughput

0.489

High

943274

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.489

High

948593

RT09
Small ribosomal subunit protein uS9m

1

8

High-throughput

0.489

High

1051792

IL27B
Interleukin-27 subunit beta

1

8

High-throughput

0.489

High

1133216

ISK14
Serine protease inhibitor Kazal-type 14

1

1

High-throughput

0.489

High

1133218

PRR27
Proline-rich protein 27

1

13

High-throughput

0.489

High

1133225

MAVS
Mitochondrial antiviral-signaling protein

1

17

High-throughput

0.489

High

1133230

SULF2
Extracellular sulfatase Sulf-2

1

3

High-throughput

0.489

High

1133232

CBPA6
Carboxypeptidase A6

1

2

High-throughput

0.489

High

1133233

NKAP
NF-kappa-B-activating protein

1

2

High-throughput

0.489

High

1133234

LRC17
Leucine-rich repeat-containing protein 17

1

2

High-throughput

0.489

High

1133238

G45IP
Large ribosomal subunit protein mL64

1

2

High-throughput

0.489

High

1133239

FA81A
Protein FAM81A

1

1

High-throughput

0.489

High

1133240

RM30
Large ribosomal subunit protein uL30m

1

2

High-throughput

0.489

High

1133243

HASP
Serine/threonine-protein kinase haspin

1

1

High-throughput

0.489

High

1133245

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.489

High

1133246

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.489

High

1133252

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.489

High

1133254

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.489

High

1133255

OVOL2
Transcription factor Ovo-like 2

1

13

High-throughput

0.489

High

1133258

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.489

High

1133259

UBXN6
UBX domain-containing protein 6

1

4

High-throughput

0.489

High

1133263

GREM2
Gremlin-2

1

1

High-throughput

0.489

High

1133266

EMIL3
EMILIN-3

1

6

High-throughput

0.489

High

1133268

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.489

High

1133271

MRM2
rRNA methyltransferase 2, mitochondrial

1

4

High-throughput

0.489

High

1133274

PA2GD
Group IID secretory phospholipase A2

1

1

High-throughput

0.489

High

1133275

XCT
Cystine/glutamate transporter

1

4

High-throughput

0.489

High

1133276

RT07
Small ribosomal subunit protein uS7m

1

7

High-throughput

0.489

High

749574

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.481

High

160612

AURKA
Aurora kinase A

1

17

High-throughput

0.479

High

431943

HS90A
Heat shock protein HSP 90-alpha

1

18

High-throughput

0.479

High

438254

HS90B
Heat shock protein HSP 90-beta

1

18

High-throughput

0.479

High

851777

CCNG1
Cyclin-G1

1

3

High-throughput

0.479

High

961153

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1024688

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

1041751

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1133273

STX8
Syntaxin-8

1

2

Small-scale

0.479

High

505418

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

5

High-throughput

0.470

High

413947

GELS
Gelsolin

1

5

High-throughput

0.470

High

609343

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.470

High

1060451

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

9

High-throughput

0.470

High

386884

P53
Cellular tumor antigen p53

1

20

Small-scale

0.439

High

346997

MYC
Myc proto-oncogene protein

1

13

Small-scale

0.437

High

377389

GCR
Glucocorticoid receptor

1

16

High-throughput

0.437

High

384971

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.437

High

575473

EGR1
Early growth response protein 1

1

17

High-throughput

0.437

High

658968

MK01
Mitogen-activated protein kinase 1

1

3

Small-scale

0.437

High

760113

RL3
Large ribosomal subunit protein uL3

1

8

High-throughput

0.437

High

848395

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

Small-scale

0.437

High

989315

PRDX1
Peroxiredoxin-1

1

11

Small-scale

0.437

High

1035464

SMAD4
Mothers against decapentaplegic homolog 4

1

20

High-throughput

0.437

High

1078563

SMAD2
Mothers against decapentaplegic homolog 2

1

20

High-throughput

0.437

High

1133221

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1133223

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.437

High

1133250

YI001
Uncharacterized protein FLJ30774

1

1

High-throughput

0.437

High

1133262

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1133265

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

1133267

DJC28
DnaJ homolog subfamily C member 28

1

1

High-throughput

0.437

High

1133270

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.437

High

91427

E7EPC3
Protein Wnt

1

5

High-throughput

0.407

High

1133229

ZN695
Zinc finger protein 695

1

3

High-throughput

0.407

High

1133235

CI163
Uncharacterized protein C9orf163

1

1

High-throughput

0.407

High

1133241

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.407

High

1133242

CX7B2
Cytochrome c oxidase subunit 7B2, mitochondrial

1

0

High-throughput

0.279

Low

1133277

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1133248

UBX10
UBX domain-containing protein 10

1

0

High-throughput

0.249

Low

1133222

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024