Protein: SORL
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)

Gene: SORL, SORL1
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q92673

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001540 - amyloid-beta binding
GO:0002024 - diet induced thermogenesis
GO:0004888 - transmembrane signaling receptor activity
GO:0005041 - low-density lipoprotein particle receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

674705

AMRP
Alpha-2-macroglobulin receptor-associated protein

6

11

Small-scale

0.949

High

1269006

SORL
Sortilin-related receptor

4

15

Small-scale

0.907

High

588795

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

3

High-throughput

0.861

High

509877

PSG1
Pregnancy-specific beta-1-glycoprotein 1

2

5

High-throughput

0.811

High

1216966

EGFL6
Epidermal growth factor-like protein 6

2

10

High-throughput

0.811

High

160688

AURKA
Aurora kinase A

4

1

High-throughput

0.801

High

1076689

RHOH
Rho-related GTP-binding protein RhoH

2

20

High-throughput

0.783

High

645945

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

10

Small-scale

0.761

High

445725

IL6RA
Interleukin-6 receptor subunit alpha

1

12

Small-scale

0.724

High

395362

A4
Amyloid-beta precursor protein

5

15

Small-scale

0.723

High

1269037

GGA1
ADP-ribosylation factor-binding protein GGA1

5

8

Small-scale

0.720

High

439352

CATG
Cathepsin G

1

13

High-throughput

0.691

High

533026

PRG2
Bone marrow proteoglycan

1

9

High-throughput

0.691

High

536140

HGF
Hepatocyte growth factor

1

11

High-throughput

0.691

High

621380

CMA1
Chymase

1

15

High-throughput

0.691

High

1265924

CLC2B
C-type lectin domain family 2 member B

1

9

High-throughput

0.691

High

1269016

GDF15
Growth/differentiation factor 15

1

2

High-throughput

0.691

High

1269017

SOST
Sclerostin

1

5

High-throughput

0.691

High

1269019

BSSP4
Brain-specific serine protease 4

1

9

High-throughput

0.691

High

1269020

SIRPD
Signal-regulatory protein delta

1

3

High-throughput

0.691

High

1269034

BTNL2
Butyrophilin-like protein 2

1

2

High-throughput

0.691

High

265785

CRLF1
Cytokine receptor-like factor 1

1

13

Small-scale

0.681

High

399182

IL6
Interleukin-6

1

1

Small-scale

0.681

High

1269036

GGA2
ADP-ribosylation factor-binding protein GGA2

3

8

Small-scale

0.674

High

119465

LEG9
Galectin-9

3

5

High-throughput

0.667

High

121199

LEG8
Galectin-8

3

5

High-throughput

0.667

High

383909

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

18

Small-scale

0.647

High

601966

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

19

Small-scale

0.647

High

1269014

SORT
Sortilin

1

4

Small-scale

0.647

High

764752

GDNF
Glial cell line-derived neurotrophic factor

1

0

Small-scale

0.646

High

313116

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

2

1

High-throughput

0.628

High

738981

SRBP1
Sterol regulatory element-binding protein 1

2

4

High-throughput

0.628

High

1034505

OS9
Protein OS-9

2

1

High-throughput

0.628

High

1190913

TAFA3
Chemokine-like protein TAFA-3

2

8

High-throughput

0.628

High

389483

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.618

High

1165524

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.618

High

1231741

AN36B
Ankyrin repeat domain-containing protein 36B

1

9

High-throughput

0.618

High

1259455

NET5
Netrin-5

1

8

High-throughput

0.618

High

312833

CCN6
Cellular communication network factor 6

2

3

High-throughput

0.611

High

1110302

SP6
Transcription factor Sp6

3

9

High-throughput

0.609

High

1237971

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

1269027

FBX6
F-box only protein 6

3

8

High-throughput

0.599

High

213902

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

10

High-throughput

0.595

High

361508

APOE
Apolipoprotein E

2

7

Small-scale

0.595

High

67766

ZBBX
Zinc finger B-box domain-containing protein 1

2

1

High-throughput

0.574

High

200259

ZN264
Zinc finger protein 264

2

2

High-throughput

0.574

High

1060253

ZN169
Zinc finger protein 169

2

3

High-throughput

0.574

High

1153134

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

2

High-throughput

0.574

High

1168507

ZN517
Zinc finger protein 517

2

17

High-throughput

0.574

High

1205167

Z354C
Zinc finger protein 354C

2

10

High-throughput

0.574

High

1250765

ZN563
Zinc finger protein 563

2

3

High-throughput

0.574

High

1269022

ZN408
Zinc finger protein 408

2

11

High-throughput

0.574

High

1269026

ZN331
Zinc finger protein 331

2

7

High-throughput

0.574

High

1269030

ZN224
Zinc finger protein 224

2

4

High-throughput

0.574

High

1254864

SP7
Transcription factor Sp7

2

9

High-throughput

0.565

High

1160497

ZN549
Zinc finger protein 549

2

1

High-throughput

0.558

High

452846

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

2

2

High-throughput

0.558

High

944072

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.553

High

1171059

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

1269042

DUS10
Dual specificity protein phosphatase 10

1

3

High-throughput

0.553

High

211388

PI15
Peptidase inhibitor 15

1

5

High-throughput

0.536

High

217396

VEGFD
Vascular endothelial growth factor D

1

3

High-throughput

0.536

High

328157

SG1D1
Secretoglobin family 1D member 1

1

3

High-throughput

0.536

High

449330

LEG1
Galectin-1

1

5

High-throughput

0.536

High

452001

WNT2
Protein Wnt-2

1

13

High-throughput

0.536

High

474756

CFC1
Cryptic protein

1

2

High-throughput

0.536

High

529499

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

535667

EDN3
Endothelin-3

1

3

High-throughput

0.536

High

588307

FST
Follistatin

1

3

High-throughput

0.536

High

595699

MIME
Mimecan

1

8

High-throughput

0.536

High

654624

CALX
Calnexin

1

5

High-throughput

0.536

High

726528

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.536

High

817020

TFPI2
Tissue factor pathway inhibitor 2

1

15

High-throughput

0.536

High

873729

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

960729

NDP
Norrin

1

2

High-throughput

0.536

High

1041124

CUL1
Cullin-1

1

11

High-throughput

0.536

High

1059127

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.536

High

1166386

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.536

High

1232364

TAFA2
Chemokine-like protein TAFA-2

1

8

High-throughput

0.536

High

1253850

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

1269012

TAFA4
Chemokine-like protein TAFA-4

1

8

High-throughput

0.536

High

1269021

GREM2
Gremlin-2

1

2

High-throughput

0.536

High

1269024

CDHR5
Cadherin-related family member 5

1

5

High-throughput

0.536

High

1269025

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

1269029

CBLN4
Cerebellin-4

1

4

High-throughput

0.536

High

1269032

DKK2
Dickkopf-related protein 2

1

8

High-throughput

0.536

High

1269038

FBX2
F-box only protein 2

1

8

High-throughput

0.536

High

200417

HS12A
Heat shock 70 kDa protein 12A

1

0

Small-scale

0.529

High

1164180

BRWD3
Bromodomain and WD repeat-containing protein 3

1

0

High-throughput

0.517

High

798548

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

1

High-throughput

0.515

High

1044007

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.514

High

785681

ASIP
Agouti-signaling protein

1

0

High-throughput

0.513

High

879748

GFRA1
GDNF family receptor alpha-1

1

0

Small-scale

0.505

High

337025

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.493

High

49253

FEZF1
Fez family zinc finger protein 1

1

13

High-throughput

0.489

High

485379

GLI4
Zinc finger protein GLI4

1

11

High-throughput

0.489

High

563757

ZNF26
Zinc finger protein 26

1

4

High-throughput

0.489

High

600976

MK
Midkine

1

4

High-throughput

0.489

High

1012654

ZN816
Zinc finger protein 816

1

6

High-throughput

0.489

High

1023742

TRAF1
TNF receptor-associated factor 1

1

2

High-throughput

0.489

High

1083635

ZNF74
Zinc finger protein 74

1

9

High-throughput

0.489

High

1084750

TAZ
Tafazzin

1

4

High-throughput

0.489

High

1103476

ZN284
Zinc finger protein 284

1

4

High-throughput

0.489

High

1110364

FX4L6
Forkhead box protein D4-like 6

1

7

High-throughput

0.489

High

1169828

FOXI2
Forkhead box protein I2

1

7

High-throughput

0.489

High

1217397

ZN584
Zinc finger protein 584

1

11

High-throughput

0.489

High

1223925

ZNF34
Zinc finger protein 34

1

10

High-throughput

0.489

High

1235846

DB123
Beta-defensin 123

1

3

High-throughput

0.489

High

1237395

ZN713
Zinc finger protein 713

1

15

High-throughput

0.489

High

1241513

ZN485
Zinc finger protein 485

1

10

High-throughput

0.489

High

1263235

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.489

High

1269007

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.489

High

1269010

ZN707
Zinc finger protein 707

1

19

High-throughput

0.489

High

1269018

SCRT1
Transcriptional repressor scratch 1

1

12

High-throughput

0.489

High

1269028

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.489

High

1269035

SALL4
Sal-like protein 4

1

7

High-throughput

0.489

High

1269039

ZN777
Zinc finger protein 777

1

10

High-throughput

0.489

High

1269041

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

10

High-throughput

0.489

High

906053

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.486

High

205777

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

649644

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

677619

NEUT
Neurotensin/neuromedin N [Cleaved into: Large neuromedin N

1

1

Small-scale

0.479

High

996502

FGL1
Fibrinogen-like protein 1

1

4

High-throughput

0.479

High

1042190

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1163080

APOA5
Apolipoprotein A-V

1

7

Small-scale

0.479

High

1269009

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1269031

CLCF1
Cardiotrophin-like cytokine factor 1

1

2

Small-scale

0.479

High

1269033

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

949857

CBX1
Chromobox protein homolog 1

1

1

High-throughput

0.470

High

1269008

KAT5
Histone acetyltransferase KAT5

1

3

High-throughput

0.470

High

1167218

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

Small-scale

0.458

High

1269015

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

1269013

FRMD6
FERM domain-containing protein 6

1

1

High-throughput

0.445

High

1101905

RSPO1
R-spondin-1

1

6

High-throughput

0.437

High

1139544

SLX4I
Protein SLX4IP

1

1

Small-scale

0.437

High

1218162

CEP97
Centrosomal protein of 97 kDa

1

2

High-throughput

0.437

High

1269023

SP110
Sp110 nuclear body protein

1

5

High-throughput

0.437

High

1236258

CD177
CD177 antigen

1

0

Small-scale

0.426

High

484916

GOG8G
Putative golgin subfamily A member 8G

1

6

High-throughput

0.407

High

548322

FOSL2
Fos-related antigen 2

3

0

High-throughput

0.347

High

1126289

FA76B
Protein FAM76B

2

0

High-throughput

0.318

High

679021

HXC12
Homeobox protein Hox-C12

1

0

High-throughput

0.279

Low

929014

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.279

Low

1184929

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.279

Low

1269040

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.279

Low

584032

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

588922

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.268

Low

1229598

Q8N0S8
VPS29 protein

1

0

High-throughput

0.268

Low

1269011

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

897588

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

1062182

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024