Protein: COMT
Catechol O-methyltransferase (EC 2.1.1.6)

Gene: COMT
Organism: Homo sapiens
Interactions: 162
UniProt ID: P21964

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001662 - behavioral fear response
GO:0001666 - response to hypoxia
GO:0001963 - synaptic transmission, dopaminergic
GO:0001964 - startle response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

602544

TM205
Transmembrane protein 205

3

0

High-throughput

0.636

High

602528

PCH2
Pachytene checkpoint protein 2 homolog

3

1

High-throughput

0.628

High

156971

FFAR3
Free fatty acid receptor 3

2

1

High-throughput

0.606

High

274150

CXB3
Gap junction beta-3 protein

2

3

High-throughput

0.606

High

306758

VAMP5
Vesicle-associated membrane protein 5

2

1

High-throughput

0.606

High

602499

CTR1
High affinity cationic amino acid transporter 1

2

1

High-throughput

0.606

High

602501

CNR2
Cannabinoid receptor 2

2

2

High-throughput

0.606

High

602530

VAMP3
Vesicle-associated membrane protein 3

2

1

High-throughput

0.606

High

602558

GP152
Probable G-protein coupled receptor 152

2

1

High-throughput

0.606

High

602564

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

602572

S1PR3
Sphingosine 1-phosphate receptor 3

2

2

High-throughput

0.606

High

602590

S39A2
Zinc transporter ZIP2

2

6

High-throughput

0.606

High

602593

CXB4
Gap junction beta-4 protein

2

3

High-throughput

0.606

High

602597

S39A1
Zinc transporter ZIP1

2

6

High-throughput

0.606

High

602605

LAT2
Large neutral amino acids transporter small subunit 2

2

1

High-throughput

0.606

High

602570

RUFY1
RUN and FYVE domain-containing protein 1

2

0

High-throughput

0.585

High

62031

MADL2
Myeloid-associated differentiation marker-like protein 2

2

0

High-throughput

0.580

High

70797

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

238221

MOT2
Monocarboxylate transporter 2

2

0

High-throughput

0.580

High

274867

RHBL1
Rhomboid-related protein 1

2

0

High-throughput

0.580

High

310424

KCNK5
Potassium channel subfamily K member 5

2

0

High-throughput

0.580

High

323474

TM50A
Transmembrane protein 50A

2

0

High-throughput

0.580

High

602492

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

2

0

High-throughput

0.580

High

602498

V2R
Vasopressin V2 receptor

2

0

High-throughput

0.580

High

602502

TRFR
Thyrotropin-releasing hormone receptor

2

0

High-throughput

0.580

High

602507

EMD
Emerin

2

0

High-throughput

0.580

High

602521

NIPA4
Magnesium transporter NIPA4

2

0

High-throughput

0.580

High

602525

TM187
Transmembrane protein 187

2

0

High-throughput

0.580

High

602533

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

602534

F209A
Protein FAM209A

2

0

High-throughput

0.580

High

602535

MF14B
Hippocampus abundant transcript-like protein 1

2

0

High-throughput

0.580

High

602542

HRG1
Heme transporter HRG1

2

0

High-throughput

0.580

High

602546

OTOP3
Proton channel OTOP3

2

0

High-throughput

0.580

High

602549

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.580

High

602552

GP161
G-protein coupled receptor 161

2

0

High-throughput

0.580

High

602555

BEST2
Bestrophin-2a

2

0

High-throughput

0.580

High

602567

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

602581

TM222
Transmembrane protein 222

2

0

High-throughput

0.580

High

602596

TM100
Transmembrane protein 100

2

0

High-throughput

0.580

High

602606

PGAP2
Post-GPI attachment to proteins factor 2

2

0

High-throughput

0.580

High

602609

THS7A
Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]

2

0

High-throughput

0.580

High

602612

SELK
Selenoprotein K

2

0

High-throughput

0.580

High

602527

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.573

High

602540

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.573

High

312702

CXB5
Gap junction beta-5 protein

2

3

High-throughput

0.553

High

434813

CXB1
Gap junction beta-1 protein

2

3

High-throughput

0.553

High

602541

RHBD2
Rhomboid domain-containing protein 2

2

1

High-throughput

0.553

High

602582

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.553

High

602594

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.553

High

602602

TM14C
Transmembrane protein 14C

2

1

High-throughput

0.553

High

602494

KRA59
Keratin-associated protein 5-9

1

0

High-throughput

0.549

High

602497

CDC27
Cell division cycle protein 27 homolog

1

0

High-throughput

0.549

High

592098

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

602551

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

212596

AP1G1
AP-1 complex subunit gamma-1

1

3

High-throughput

0.536

High

276356

AP1G2
AP-1 complex subunit gamma-like 2

1

3

High-throughput

0.536

High

302100

AP2A2
AP-2 complex subunit alpha-2

1

3

High-throughput

0.536

High

602512

AP1S2
AP-1 complex subunit sigma-2

1

3

High-throughput

0.536

High

602517

AP1S1
AP-1 complex subunit sigma-1A

1

3

High-throughput

0.536

High

602518

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

602522

AP1B1
AP-1 complex subunit beta-1

1

2

High-throughput

0.536

High

602561

US6NL
USP6 N-terminal-like protein

1

1

High-throughput

0.536

High

602568

AP1S3
AP-1 complex subunit sigma-3

1

3

High-throughput

0.536

High

602601

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

602506

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.518

High

602509

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.518

High

181978

GPR42
G-protein coupled receptor 42

1

1

High-throughput

0.515

High

602491

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.515

High

362812

FINC
Fibronectin

1

0

High-throughput

0.513

High

394119

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.513

High

431308

LDHC
L-lactate dehydrogenase C chain

1

0

High-throughput

0.513

High

436011

CO1A2
Collagen alpha-2(I) chain

1

0

High-throughput

0.513

High

602523

RIN1
Ras and Rab interactor 1

1

0

High-throughput

0.513

High

602536

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.513

High

602563

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

602577

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.513

High

602578

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

602583

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.513

High

602610

EXO1
Exonuclease 1

1

0

High-throughput

0.513

High

153568

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.493

High

167666

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

0

High-throughput

0.493

High

281542

WFS1
Wolframin

1

0

High-throughput

0.493

High

413829

GELS
Gelsolin

1

0

High-throughput

0.493

High

594675

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

High-throughput

0.493

High

602496

EPHB2
Ephrin type-B receptor 2

1

0

High-throughput

0.493

High

602562

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

0

High-throughput

0.493

High

602608

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.493

High

602504

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.486

High

602580

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.486

High

146890

AQP7
Aquaporin-7

1

1

High-throughput

0.481

High

602513

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

602514

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

602515

RAB14
Ras-related protein Rab-14

1

1

High-throughput

0.479

High

602548

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

602554

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

602565

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

602585

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

602586

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

602600

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

602604

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

602537

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

1

High-throughput

0.470

High

602543

Q6P5T0
AQP7 protein

1

1

High-throughput

0.470

High

602553

WDR31
WD repeat-containing protein 31

1

2

High-throughput

0.470

High

602505

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.460

High

345923

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

373681

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

375708

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.458

High

602493

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

602508

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

602510

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

602511

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

602520

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

602526

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

602547

PEG10
Retrotransposon-derived protein PEG10

1

0

Small-scale

0.458

High

602559

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.458

High

602560

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

602569

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

602571

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

602574

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

602576

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

602589

MLXPL
Carbohydrate-responsive element-binding protein

1

0

Small-scale

0.458

High

602591

ANLN
Anillin

1

0

High-throughput

0.458

High

602592

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

216667

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.457

High

87347

C9JAW5
HIG1 domain-containing protein

1

1

High-throughput

0.445

High

602573

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

High-throughput

0.438

High

258405

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.437

High

602529

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.437

High

602557

RDH11
Retinol dehydrogenase 11

1

1

High-throughput

0.437

High

602611

HIG1A
HIG1 domain family member 1A, mitochondrial

1

1

High-throughput

0.437

High

377927

PRIO
Major prion protein

1

0

High-throughput

0.426

High

49304

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

123362

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.316

High

602500

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

602538

S35F1
Solute carrier family 35 member F1

2

0

High-throughput

0.316

High

602556

CC4L
C-C motif chemokine 4-like

2

0

High-throughput

0.316

High

602566

S35A4
Probable UDP-sugar transporter protein SLC35A4

2

0

High-throughput

0.316

High

602587

REEP4
Receptor expression-enhancing protein 4

2

0

High-throughput

0.316

High

447020

FGF2
Fibroblast growth factor 2

1

0

High-throughput

0.279

Low

602539

CCD18
Coiled-coil domain-containing protein 18

1

0

High-throughput

0.279

Low

602595

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low

602598

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

602603

CLIP2
CAP-Gly domain-containing linker protein 2

1

0

High-throughput

0.279

Low

276785

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.268

Low

602524

SEPT6
Septin-6

1

0

High-throughput

0.268

Low

602531

RSPO1
R-spondin-1

1

0

High-throughput

0.268

Low

602550

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.268

Low

602588

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.268

Low

602599

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.268

Low

602607

RIMS3
Regulating synaptic membrane exocytosis protein 3

1

0

High-throughput

0.268

Low

602575

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

100477

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

243929

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

551941

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

602495

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

602503

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

602516

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

602519

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

602545

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

602579

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

602584

TMX1
Thioredoxin-related transmembrane protein 1

1

0

High-throughput

0.249

Low

602532

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024