Protein: DHRS4
Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2) (Short-chain dehydrogenase/reductase family member 4)

Gene: DHRS4
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q9BTZ2

Gene Ontology (top 5):
GO:0000253 - 3-keto sterol reductase activity
GO:0001758 - retinal dehydrogenase activity
GO:0004090 - carbonyl reductase (NADPH) activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1162732

DR4L2
Dehydrogenase/reductase SDR family member 4-like 2

2

16

High-throughput

0.712

High

277578

DHRS3
Short-chain dehydrogenase/reductase 3

1

17

High-throughput

0.691

High

1308584

DHB14
17-beta-hydroxysteroid dehydrogenase 14

1

17

High-throughput

0.691

High

1312488

DHRS6
Dehydrogenase/reductase SDR family member 6

1

16

High-throughput

0.691

High

671009

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

3

1

High-throughput

0.667

High

100146

F6VUV4
Dehydrogenase/reductase 4 like 2

3

8

High-throughput

0.640

High

311283

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

3

0

High-throughput

0.638

High

676700

AL1B1
Aldehyde dehydrogenase X, mitochondrial

3

0

High-throughput

0.638

High

976254

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.638

High

1286576

BIRC7
Baculoviral IAP repeat-containing protein 7

3

0

High-throughput

0.638

High

1312490

RM37
Large ribosomal subunit protein mL37

3

0

High-throughput

0.638

High

840312

PEX5
Peroxisomal targeting signal 1 receptor

3

2

Small-scale

0.631

High

638383

RBTN2
Rhombotin-2

2

1

High-throughput

0.628

High

1312485

DHRS4
Dehydrogenase/reductase SDR family member 4

1

16

High-throughput

0.618

High

851151

PRELP
Prolargin

3

1

High-throughput

0.609

High

420724

HEXA
Beta-hexosaminidase subunit alpha

2

0

High-throughput

0.602

High

595895

CP2B6
Cytochrome P450 2B6

2

0

High-throughput

0.602

High

671109

ATPD
ATP synthase subunit delta, mitochondrial

2

0

High-throughput

0.602

High

832932

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.602

High

1312487

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

1312494

SHCAF
SIN3-HDAC complex-associated factor

2

0

High-throughput

0.602

High

259132

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

2

0

High-throughput

0.585

High

1312489

RM13
Large ribosomal subunit protein uL13m

2

0

High-throughput

0.585

High

440702

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.536

High

1312493

GSX1
GS homeobox 1

1

2

High-throughput

0.536

High

398397

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

517850

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

0

High-throughput

0.513

High

796168

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

959290

S25A3
Solute carrier family 25 member 3

1

0

High-throughput

0.513

High

1154294

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.513

High

1159924

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1260729

NAT14
Probable N-acetyltransferase 14

1

0

High-throughput

0.513

High

1310417

FSP1
Ferroptosis suppressor protein 1

1

0

High-throughput

0.513

High

1312492

CST11
Cystatin-11

1

0

High-throughput

0.513

High

620001

DGKA
Diacylglycerol kinase alpha

1

0

High-throughput

0.493

High

1312500

M2GD
Dimethylglycine dehydrogenase, mitochondrial

1

0

High-throughput

0.493

High

1295362

HIPL1
HHIP-like protein 1

1

1

High-throughput

0.489

High

116620

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

3

High-throughput

0.479

High

214362

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

216093

NRDC
Nardilysin

1

4

High-throughput

0.479

High

265014

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

370336

ESR1
Estrogen receptor

1

5

High-throughput

0.479

High

373417

CATA
Catalase

1

2

High-throughput

0.479

High

387420

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

520738

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

726385

BASI
Basigin

1

1

High-throughput

0.479

High

961260

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

1014477

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1022588

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.479

High

1086760

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

1127407

PREP
Presequence protease, mitochondrial

1

4

High-throughput

0.479

High

1136730

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

1

1

High-throughput

0.479

High

1197943

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

2

High-throughput

0.479

High

1221693

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1245003

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

1

High-throughput

0.479

High

1269496

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1284379

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

High-throughput

0.479

High

1312498

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

262088

PEX14
Peroxisomal membrane protein PEX14

1

0

Small-scale

0.464

High

50398

NDUF8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

1

0

High-throughput

0.458

High

266798

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

450936

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

877863

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

1163828

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.458

High

1312486

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.458

High

1312491

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.458

High

1312502

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1312503

BOLA1
BolA-like protein 1

1

0

High-throughput

0.458

High

1312504

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

1171491

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1312501

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.437

High

473766

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

3

0

High-throughput

0.347

High

1086957

QPCT
Glutaminyl-peptide cyclotransferase

3

0

High-throughput

0.347

High

1264857

KLHL6
Kelch-like protein 6

2

0

High-throughput

0.328

High

1285823

TRI43
Tripartite motif-containing protein 43

2

0

High-throughput

0.328

High

1312499

SUN2
SUN domain-containing protein 2

2

0

High-throughput

0.328

High

1131309

LY65C
Lymphocyte antigen 6 complex locus protein G5c

1

0

High-throughput

0.279

Low

1266026

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1312495

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

1312497

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

880465

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.249

Low

1086475

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.249

Low

1291043

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

1

0

High-throughput

0.249

Low

1294374

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.249

Low

1312496

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024