Protein: PLK4
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase SAK)

Gene: PLK4, SAK
Organism: Drosophila melanogaster
Interactions: 92
UniProt ID: O97143

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

332648

PLK4
Serine/threonine-protein kinase PLK4

9

18

Small-scale

0.983

High

332702

Q9VNE4
Asterless

11

11

Small-scale

0.762

High

332693

Q9VDE3
LD08669p

9

9

Small-scale

0.748

High

332654

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

2

9

Small-scale

0.675

High

332656

CCNC
Cyclin-C

1

1

High-throughput

0.656

High

332667

Q7K306
Cyclin-dependent kinase 4, isoform A

1

8

High-throughput

0.656

High

332685

Q961D1
Cyclin K, isoform A

1

2

High-throughput

0.656

High

284963

O77430
GEO01111p1

3

6

Small-scale

0.656

High

332722

Q9XZ31
Anastral spindle 2, isoform A

3

2

Small-scale

0.650

High

332683

CYCG
Cyclin G

1

0

High-throughput

0.622

High

332659

POLO
Serine/threonine-protein kinase polo

1

16

High-throughput

0.621

High

332682

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.621

High

332696

Q9VGF9
Aurora kinase

1

17

High-throughput

0.621

High

332715

SF3B3
Splicing factor 3B subunit 3

1

7

High-throughput

0.621

High

332721

Q9W418
GH17761p

1

9

Small-scale

0.618

High

332688

Q9I7T8
PAN2-PAN3 deadenylation complex subunit PAN3

1

1

High-throughput

0.590

High

332666

Q7K0V7
LD27656p

1

7

High-throughput

0.587

High

332690

CEG1A
Centaurin-gamma-1A

1

2

High-throughput

0.587

High

332655

SGG
Protein kinase shaggy

1

8

High-throughput

0.575

High

332684

Q960T6
Centrosomal protein 135kDa, isoform A

1

11

High-throughput

0.573

High

332668

Q7PLE9
Ras-related protein Rab-21

1

16

High-throughput

0.555

High

332675

Q8SXN9
polynucleotide adenylyltransferase

1

3

High-throughput

0.555

High

52132

A1Z743
polynucleotide adenylyltransferase

1

3

High-throughput

0.528

High

332671

Q8MRG8
Ras-related protein Rab-21

1

16

High-throughput

0.528

High

332680

Q8T9L6
Splicing factor 3B subunit 3

1

7

High-throughput

0.528

High

51258

GUS
Protein gustavus

1

11

High-throughput

0.508

High

80864

DIMM
Protein dimmed

1

3

High-throughput

0.508

High

332651

BCD
Homeotic protein bicoid

1

6

High-throughput

0.508

High

332657

ECR
Ecdysone receptor

1

8

High-throughput

0.508

High

332658

ATPA
ATP synthase subunit alpha, mitochondrial

1

5

High-throughput

0.508

High

332661

FTF1B
Nuclear hormone receptor FTZ-F1 beta

1

8

High-throughput

0.508

High

332664

RAD51
DNA repair protein Rad51 homolog

1

1

High-throughput

0.508

High

332687

Q9I7L0
LP01847p

1

1

High-throughput

0.508

High

332694

Q9VFQ3
E5

1

3

High-throughput

0.508

High

332699

Q9VL21
LD11652p

1

5

High-throughput

0.508

High

332707

FRY
Protein furry

1

3

High-throughput

0.508

High

332709

Q9VUD3
GH07353p

1

14

High-throughput

0.508

High

332720

AAAS
Aladin

1

4

High-throughput

0.508

High

332723

MED15
Mediator of RNA polymerase II transcription subunit 15

1

5

High-throughput

0.508

High

332704

Q9VQV7
Centrosomal protein 97kDa, isoform B

1

9

Small-scale

0.501

High

332710

Q9VV79
BcDNA.LD24702

1

1

Small-scale

0.501

High

332649

TBA1
Tubulin alpha-1 chain

1

10

Small-scale

0.500

High

332652

HSP7D
Heat shock 70 kDa protein cognate 4

1

3

Small-scale

0.500

High

332663

TBB1
Tubulin beta-1 chain

1

9

Small-scale

0.500

High

332679

Q8T965
Prefoldin subunit 3

1

0

High-throughput

0.486

High

332700

Q9VL27
Alpha-galactosidase

1

0

High-throughput

0.486

High

81465

B7Z143
Protein interacting with Ttk69 and Sin3A, isoform D

1

1

High-throughput

0.481

High

116384

M9PI43
Centriolar coiled coil protein 110kDa, isoform F

1

1

High-throughput

0.481

High

332665

Q5U0Y0
LD13852p

1

3

High-throughput

0.481

High

332670

PANG2
Protein pangolin, isoform J

1

11

High-throughput

0.481

High

332686

Q961D7
LD07765p

1

2

High-throughput

0.481

High

332703

Q9VQ95
Testis EndoG-Like 3

1

1

High-throughput

0.481

High

332717

Q9W1H7
Putative homeodomain protein

1

1

High-throughput

0.481

High

332662

CUL1
Cullin homolog 1

1

7

Small-scale

0.479

High

332678

ENA
Protein enabled

1

2

High-throughput

0.464

High

332695

Q9VG22
Davis-cup

1

20

High-throughput

0.464

High

332701

POLZ2
DNA polymerase zeta subunit 2

1

2

High-throughput

0.464

High

332705

Q9VRQ4
LD47944p

1

1

High-throughput

0.464

High

332706

Q9VS41
Unc-13-4A, isoform B

1

2

High-throughput

0.464

High

332716

Q9W0Y0
RE57840p

1

2

High-throughput

0.464

High

53875

A1Z927
Sin3A, isoform A

1

3

High-throughput

0.457

High

283683

O76136
Homeodomain protein

1

2

High-throughput

0.457

High

332672

Q8MS22
RE41430p

1

1

High-throughput

0.457

High

332714

Q9VZU6
BTB-VII protein domain

1

5

High-throughput

0.457

High

246708

TENM
Teneurin-m

1

1

High-throughput

0.445

High

332650

TBB3
Tubulin beta-3 chain

1

9

Small-scale

0.445

High

332697

Q9VH81
protein-serine/threonine phosphatase

1

12

High-throughput

0.445

High

51311

A1Z6E8
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

52570

A1Z7M3
Notopleural, isoform A

1

1

High-throughput

0.439

High

91170

E3CTS2
MIP27658p

1

1

High-throughput

0.439

High

115552

M9PFH3
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

332669

Q7Z2C5
Uncharacterized protein

1

4

High-throughput

0.439

High

332691

Q9VAZ0
FI05230p

1

1

High-throughput

0.439

High

332660

PANG1
Protein pangolin, isoforms A/H/I/S

1

10

High-throughput

0.417

High

332673

Q8MSW5
LD24928p

1

1

High-throughput

0.417

High

332676

Q8SYU4
RE33778p

1

2

High-throughput

0.417

High

332681

Q95RL9
LD20432p

1

1

High-throughput

0.417

High

332708

Q9VU23
Uncharacterized protein, isoform E

1

1

High-throughput

0.417

High

332712

Q9VYF9
RE28286p

1

7

High-throughput

0.417

High

332692

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.282

High

220793

O46070
EG:25E8.4 protein

1

0

High-throughput

0.265

Low

220893

PGAM5
Serine/threonine-protein phosphatase Pgam5, mitochondrial

1

0

High-throughput

0.265

Low

332653

VTU2
Vitelline membrane protein Vm26Ab

1

0

High-throughput

0.265

Low

332674

Q8SXL5
RE09177p

1

0

High-throughput

0.265

Low

332677

Q8SZP2
RE71854p

1

0

High-throughput

0.265

Low

332689

Q9I7Z8
LD21943p

1

0

High-throughput

0.265

Low

332698

PPT2
Lysosomal thioesterase PPT2 homolog

1

0

High-throughput

0.265

Low

332711

Q9VWT7
GEO07745p1

1

0

High-throughput

0.265

Low

332713

Q9VZG2
Cuticular protein 64Aa

1

0

High-throughput

0.265

Low

332718

Q9W1P1
Cilia- and flagella-associated protein 61 N-terminal domain-containing protein

1

0

High-throughput

0.265

Low

332719

Q9W221
MIP04282p

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024