Protein: PITX1
Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1)

Gene: PITX1
Organism: Homo sapiens
Interactions: 128
UniProt ID: P78337

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 - skeletal system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

241218

TBX19
T-box transcription factor TBX19

2

9

High-throughput

0.783

High

724215

MSX2
Homeobox protein MSX-2

2

18

High-throughput

0.783

High

829821

HXA1
Homeobox protein Hox-A1

2

20

High-throughput

0.783

High

941972

TBX22
T-box transcription factor TBX22

2

7

High-throughput

0.783

High

941942

RBPMS
RNA-binding protein with multiple splicing

6

1

High-throughput

0.744

High

150341

CDX4
Homeobox protein CDX-4

1

19

High-throughput

0.698

High

941953

RHXF2
Rhox homeobox family member 2

1

16

High-throughput

0.698

High

656400

PIT1
Pituitary-specific positive transcription factor 1

1

16

Small-scale

0.680

High

297170

IPO13
Importin-13

3

8

High-throughput

0.667

High

941941

DVL3
Segment polarity protein dishevelled homolog DVL-3

3

2

High-throughput

0.667

High

734592

TRI23
E3 ubiquitin-protein ligase TRIM23

3

0

High-throughput

0.639

High

941952

SPAG8
Sperm-associated antigen 8

3

0

High-throughput

0.639

High

941973

MAGD1
Melanoma-associated antigen D1

3

0

High-throughput

0.639

High

211823

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.618

High

941905

TBR1
T-box brain protein 1

1

9

High-throughput

0.618

High

941950

PITX2
Pituitary homeobox 2

1

15

High-throughput

0.618

High

941944

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

5

High-throughput

0.611

High

64590

MYH7B
Myosin-7B

2

2

High-throughput

0.606

High

67957

VGLL3
Transcription cofactor vestigial-like protein 3

2

1

High-throughput

0.606

High

554427

GATA1
Erythroid transcription factor

2

4

High-throughput

0.606

High

941894

ARI5A
AT-rich interactive domain-containing protein 5A

2

16

High-throughput

0.606

High

941895

TLE5
TLE family member 5

2

15

High-throughput

0.606

High

941898

TP53B
TP53-binding protein 1

2

3

High-throughput

0.606

High

941899

TRAF1
TNF receptor-associated factor 1

2

2

High-throughput

0.606

High

941901

PTK6
Protein-tyrosine kinase 6

2

7

High-throughput

0.606

High

941903

LASP1
LIM and SH3 domain protein 1

2

3

High-throughput

0.606

High

941925

DZIP3
E3 ubiquitin-protein ligase DZIP3

2

3

High-throughput

0.606

High

941947

TEKT5
Tektin-5

2

1

High-throughput

0.606

High

941949

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.606

High

941965

PLS3
Phospholipid scramblase 3

2

3

High-throughput

0.606

High

941968

SRGEF
Secretion-regulating guanine nucleotide exchange factor

2

1

High-throughput

0.606

High

2756

A0A0C4DGF1
Zinc finger and BTB domain containing 32

2

1

High-throughput

0.596

High

817906

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

941971

ZBT32
Zinc finger and BTB domain-containing protein 32

2

7

High-throughput

0.584

High

60964

PSB11
Proteasome subunit beta type-11

2

0

High-throughput

0.580

High

941914

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

941922

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.580

High

941931

STH
Saitohin

2

0

High-throughput

0.580

High

941969

HSF4
Heat shock factor protein 4

2

0

High-throughput

0.580

High

941970

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

49943

F168B
Myelin-associated neurite-outgrowth inhibitor

2

1

High-throughput

0.553

High

67039

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

280562

KRT34
Keratin, type I cuticular Ha4

2

6

High-throughput

0.553

High

327975

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

1

High-throughput

0.553

High

397100

PAI1
Plasminogen activator inhibitor 1

2

3

High-throughput

0.553

High

941886

KRT83
Keratin, type II cuticular Hb3

2

3

High-throughput

0.553

High

941893

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

2

4

High-throughput

0.553

High

941906

KRA61
Keratin-associated protein 6-1

2

1

High-throughput

0.553

High

941907

KRA62
Keratin-associated protein 6-2

2

1

High-throughput

0.553

High

941909

KR195
Keratin-associated protein 19-5

2

1

High-throughput

0.553

High

941910

KR197
Keratin-associated protein 19-7

2

2

High-throughput

0.553

High

941912

KR132
Keratin-associated protein 13-2

2

2

High-throughput

0.553

High

941918

UFSP1
Inactive Ufm1-specific protease 1

2

1

High-throughput

0.553

High

941928

KRA81
Keratin-associated protein 8-1

2

1

High-throughput

0.553

High

941929

KRA71
Keratin-associated protein 7-1

2

1

High-throughput

0.553

High

941937

F168A
Protein FAM168A

2

1

High-throughput

0.553

High

941956

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.553

High

941967

ANR10
Ankyrin repeat domain-containing protein 10

2

10

High-throughput

0.553

High

170059

PLS1
Phospholipid scramblase 1

1

3

High-throughput

0.541

High

941926

RFX6
DNA-binding protein RFX6

1

1

High-throughput

0.541

High

216488

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

4

High-throughput

0.536

High

941891

PR20A
Proline-rich protein 20A

2

2

High-throughput

0.533

High

483305

TPC2B
Trafficking protein particle complex subunit 2B

1

0

Small-scale

0.529

High

941896

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.523

High

2146

SIK1B
Putative serine/threonine-protein kinase SIK1B

1

1

High-throughput

0.515

High

941923

Q86V38
Atrophin 1

1

18

High-throughput

0.515

High

941966

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.513

High

575368

EGR1
Early growth response protein 1

1

5

Small-scale

0.501

High

846744

SMCA2
Probable global transcription activator SNF2L2

1

10

Small-scale

0.501

High

941897

FOXO1
Forkhead box protein O1

1

18

Small-scale

0.501

High

941900

STF1
Steroidogenic factor 1

1

14

Small-scale

0.501

High

159953

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.494

High

941945

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.494

High

941954

LZTS2
Leucine zipper putative tumor suppressor 2

1

5

High-throughput

0.494

High

941964

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

8

High-throughput

0.494

High

941939

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

941951

MDFI
MyoD family inhibitor

1

0

High-throughput

0.493

High

941946

SAHH3
Adenosylhomocysteinase 3

1

4

High-throughput

0.489

High

869449

ATN1
Atrophin-1

1

14

High-throughput

0.481

High

883217

SIK1
Serine/threonine-protein kinase SIK1

1

1

High-throughput

0.481

High

941932

ZNF34
Zinc finger protein 34

1

2

High-throughput

0.481

High

941938

TSC1
Hamartin

1

3

High-throughput

0.481

High

160509

AURKA
Aurora kinase A

1

4

High-throughput

0.479

High

162622

XPO1
Exportin-1

1

8

High-throughput

0.479

High

737737

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

831204

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.479

High

917095

H4
Histone H4

1

1

High-throughput

0.479

High

934642

H31
Histone H3.1

1

2

High-throughput

0.479

High

941887

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.479

High

941888

H33
Histone H3.3

1

2

High-throughput

0.479

High

941892

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

941936

SP7
Transcription factor Sp7

1

3

High-throughput

0.479

High

941940

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.479

High

941948

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

941955

KLF16
Krueppel-like factor 16

1

5

High-throughput

0.479

High

941957

P63
Tumor protein 63

1

4

Small-scale

0.479

High

941960

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

941962

WDR6
tRNA

1

3

High-throughput

0.479

High

103513

G4XUV3
Putative hydroxypyruvate isomerase

1

1

High-throughput

0.470

High

941890

PR20D
Proline-rich protein 20D

1

2

High-throughput

0.470

High

941924

Q86WV8
TSC complex subunit 1

1

1

High-throughput

0.470

High

941930

Q8IV28
NID2 protein

1

1

High-throughput

0.470

High

941961

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

941958

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

941902

NID2
Nidogen-2

1

1

High-throughput

0.439

High

941916

HYI
Putative hydroxypyruvate isomerase

1

1

High-throughput

0.439

High

941927

KR131
Keratin-associated protein 13-1

1

2

High-throughput

0.439

High

941889

PR20C
Proline-rich protein 20C

1

2

High-throughput

0.417

High

180696

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.316

High

278601

DCTN3
Dynactin subunit 3

2

0

High-throughput

0.316

High

474654

NHLC4
NHL-repeat-containing protein 4

2

0

High-throughput

0.316

High

770266

CEAM6
Carcinoembryonic antigen-related cell adhesion molecule 6

2

0

High-throughput

0.316

High

941904

S15A2
Solute carrier family 15 member 2

2

0

High-throughput

0.316

High

941913

KLH26
Kelch-like protein 26

2

0

High-throughput

0.316

High

941915

CJ055
Uncharacterized protein C10orf55

2

0

High-throughput

0.316

High

941917

CI057
Uncharacterized protein C9orf57

2

0

High-throughput

0.316

High

941920

KR261
Keratin-associated protein 26-1

2

0

High-throughput

0.316

High

941921

IGFL2
Insulin growth factor-like family member 2

2

0

High-throughput

0.316

High

941933

MET27
Methyltransferase-like protein 27

2

0

High-throughput

0.316

High

941934

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

2

0

High-throughput

0.316

High

941935

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

941943

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

941959

CFA68
Cilia- and flagella-associated protein 68

2

0

High-throughput

0.316

High

941963

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

941911

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

2

0

High-throughput

0.304

High

941919

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.282

High

941908

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

898003

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024