Protein: CDK8
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (DmCdk8) (Mediator complex subunit Cdk8) (Mediator of RNA polymerase II transcription subunit Cdk8)

Gene: CDK8
Organism: Drosophila melanogaster
Interactions: 51
UniProt ID: Q9VT57

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625727

CCNC
Cyclin-C

3

20

Small-scale

0.873

High

1373615

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

9

Small-scale

0.806

High

1182305

MED13
Mediator of RNA polymerase II transcription subunit 13

3

7

Small-scale

0.650

High

834211

DOA
Serine/threonine-protein kinase Doa

1

16

Small-scale

0.618

High

1229242

MED6
Mediator of RNA polymerase II transcription subunit 6

1

4

High-throughput

0.618

High

1373825

MED14
Mediator of RNA polymerase II transcription subunit 14

1

7

High-throughput

0.618

High

1373821

MED12
Mediator of RNA polymerase II transcription subunit 12

2

11

Small-scale

0.601

High

422908

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

0

Small-scale

0.586

High

1215351

Q8IRE7
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.575

High

709209

ECR
Ecdysone receptor

1

17

Small-scale

0.552

High

785499

MAD
Protein mothers against dpp

1

7

Small-scale

0.552

High

1099762

E2F1
Transcription factor E2f1

1

14

Small-scale

0.515

High

55293

A1ZAK9
P-element somatic inhibitor, isoform A

1

11

Small-scale

0.479

High

56322

MED8
Mediator of RNA polymerase II transcription subunit 8

1

3

High-throughput

0.479

High

547655

DORS
Embryonic polarity protein dorsal

1

5

Small-scale

0.479

High

578756

ARM
Armadillo segment polarity protein

1

13

Small-scale

0.479

High

589672

USP
Protein ultraspiracle

1

12

Small-scale

0.479

High

611947

HSF
Heat shock factor protein

1

7

Small-scale

0.479

High

631330

BRM
ATP-dependent helicase brm

1

4

High-throughput

0.479

High

844388

DSH
Segment polarity protein dishevelled

1

3

High-throughput

0.479

High

954647

MED20
Mediator of RNA polymerase II transcription subunit 20

1

3

High-throughput

0.479

High

957373

DIF
Dorsal-related immunity factor Dif

1

5

Small-scale

0.479

High

1180516

MED29
Mediator of RNA polymerase II transcription subunit 29

1

3

High-throughput

0.479

High

1213334

OSA
Trithorax group protein osa

1

1

High-throughput

0.479

High

1279328

EBI
F-box-like/WD repeat-containing protein ebi

1

12

High-throughput

0.479

High

1325928

MED7
Mediator of RNA polymerase II transcription subunit 7

1

5

High-throughput

0.479

High

1364492

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

1

3

High-throughput

0.479

High

1364509

MED17
Mediator of RNA polymerase II transcription subunit 17

1

4

High-throughput

0.479

High

1365124

Q9VF03
Brahma associated protein 155 kDa

1

5

High-throughput

0.479

High

1371510

MED27
Mediator of RNA polymerase II transcription subunit 27

1

3

High-throughput

0.479

High

1371736

MED1
Mediator of RNA polymerase II transcription subunit 1

1

5

Small-scale

0.479

High

1372889

Q9VR42
Serine/threonine-protein kinase RIO3

1

6

High-throughput

0.479

High

1373436

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.479

High

1373820

MED11
Mediator of RNA polymerase II transcription subunit 11

1

2

High-throughput

0.479

High

1373822

BAP60
Brahma-associated protein of 60 kDa

1

1

High-throughput

0.479

High

1373824

MED30
Mediator of RNA polymerase II transcription subunit 30

1

3

High-throughput

0.479

High

1373827

MED23
Mediator of RNA polymerase II transcription subunit 23

1

3

High-throughput

0.479

High

1373828

MED16
Mediator of RNA polymerase II transcription subunit 16

1

3

High-throughput

0.479

High

1373829

MED18
Mediator of RNA polymerase II transcription subunit 18

1

3

High-throughput

0.479

High

1373830

MED15
Mediator of RNA polymerase II transcription subunit 15

1

9

High-throughput

0.479

High

1279813

INT9
Integrator complex subunit 9

1

0

Small-scale

0.458

High

1361882

INT12
Integrator complex subunit 12

1

0

Small-scale

0.458

High

1373826

INT1
Integrator complex subunit 1

1

0

Small-scale

0.458

High

1229207

ENC
Protein encore

1

2

High-throughput

0.437

High

1280245

Q960F7
SD03629p

1

10

High-throughput

0.437

High

1373819

Q9VUB7
PAX transcription activation domain interacting protein

1

13

High-throughput

0.437

High

1373823

Q9W0L7
ubiquitinyl hydrolase 1

1

11

High-throughput

0.437

High

375670

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

12

High-throughput

0.381

High

1176794

Q7JQT8
LD41464p

1

0

High-throughput

0.249

Low

1250631

MESD
LDLR chaperone boca

1

0

High-throughput

0.249

Low

1369831

Q9VL29
GEO11246p1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024