Protein: PLD2
Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2)

Gene: PLD2
Organism: Homo sapiens
Interactions: 126
UniProt ID: O14939

Gene Ontology (top 5):
GO:0004630 - phospholipase D activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006654 - phosphatidic acid biosynthetic process
GO:0007010 - cytoskeleton organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

159329

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.724

High

159335

CADH5
Cadherin-5

3

2

Small-scale

0.667

High

159330

ACM3
Muscarinic acetylcholine receptor M3

2

2

High-throughput

0.628

High

159347

CADH8
Cadherin-8

2

2

High-throughput

0.628

High

159381

GP156
Probable G-protein coupled receptor 156

2

1

High-throughput

0.628

High

159405

TNR19
Tumor necrosis factor receptor superfamily member 19

2

1

High-throughput

0.628

High

159375

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.618

High

159419

TX264
Testis-expressed protein 264

2

1

High-throughput

0.611

High

159396

DNJC7
DnaJ homolog subfamily C member 7

3

6

High-throughput

0.609

High

159356

ARF1
ADP-ribosylation factor 1

2

2

Small-scale

0.602

High

159391

CK5P3
CDK5 regulatory subunit-associated protein 3

2

0

High-throughput

0.602

High

159352

GRB2
Growth factor receptor-bound protein 2

2

4

Small-scale

0.591

High

159327

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

Small-scale

0.589

High

159323

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.578

High

159319

TBB5
Tubulin beta chain

2

2

High-throughput

0.574

High

159414

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

2

High-throughput

0.574

High

159315

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

Small-scale

0.561

High

159332

COF1
Cofilin-1

1

1

Small-scale

0.561

High

159338

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

159343

AMPH
Amphiphysin

1

3

Small-scale

0.561

High

159359

KPCD
Protein kinase C delta type

1

2

Small-scale

0.561

High

159302

DNJA2
DnaJ homolog subfamily A member 2

2

7

High-throughput

0.558

High

159355

TBB4B
Tubulin beta-4B chain

2

2

High-throughput

0.558

High

159416

CHIP
E3 ubiquitin-protein ligase CHIP

2

3

High-throughput

0.558

High

159404

ANLN
Anillin

1

1

High-throughput

0.553

High

159297

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

159322

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

159349

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

159351

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

2

High-throughput

0.536

High

159368

ASIC2
Acid-sensing ion channel 2

1

1

High-throughput

0.536

High

159393

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

159394

TMM74
Transmembrane protein 74

1

1

High-throughput

0.536

High

159363

IF4A2
Eukaryotic initiation factor 4A-II

1

0

High-throughput

0.517

High

159316

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

159303

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

159337

BASI
Basigin

1

0

High-throughput

0.513

High

159362

CUL3
Cullin-3

1

0

High-throughput

0.513

High

159387

BSND
Barttin

1

0

High-throughput

0.513

High

159369

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.512

High

131176

BIN1
Myc box-dependent-interacting protein 1

1

3

Small-scale

0.501

High

159370

DDR2
Discoidin domain-containing receptor 2

1

3

High-throughput

0.500

High

159301

TSN3
Tetraspanin-3

1

1

High-throughput

0.489

High

159304

CIB2
Calcium and integrin-binding family member 2

1

1

High-throughput

0.489

High

159305

DNJB5
DnaJ homolog subfamily B member 5

1

6

High-throughput

0.489

High

159313

FRIL
Ferritin light chain

1

1

High-throughput

0.489

High

159342

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

159353

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.489

High

159354

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.489

High

159365

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

159371

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

159379

TTC9C
Tetratricopeptide repeat protein 9C

1

1

High-throughput

0.489

High

159382

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

159386

DYT2B
Dynein light chain Tctex-type protein 2B

1

1

High-throughput

0.489

High

159410

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

2

High-throughput

0.489

High

159299

PRKN
E3 ubiquitin-protein ligase parkin

1

1

Small-scale

0.479

High

159309

BAG4
BAG family molecular chaperone regulator 4

1

2

High-throughput

0.479

High

159312

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

159326

BRAF
Serine/threonine-protein kinase B-raf

1

4

High-throughput

0.479

High

159328

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.479

High

159336

OPRM
Mu-type opioid receptor

1

3

Small-scale

0.479

High

159341

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

2

High-throughput

0.479

High

159346

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.479

High

159350

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.479

High

159364

PEA15
Astrocytic phosphoprotein PEA-15

1

1

Small-scale

0.479

High

159367

TOM34
Mitochondrial import receptor subunit TOM34

1

7

High-throughput

0.479

High

159376

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

159383

DJB14
DnaJ homolog subfamily B member 14

1

5

High-throughput

0.479

High

159388

AQP3
Aquaporin-3

1

4

Small-scale

0.479

High

159401

EGLN1
Egl nine homolog 1

1

1

Small-scale

0.479

High

159409

HACD3
Very-long-chain

1

2

High-throughput

0.479

High

159412

DNJB4
DnaJ homolog subfamily B member 4

1

6

High-throughput

0.479

High

159296

XPO1
Exportin-1

1

0

High-throughput

0.458

High

159320

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.458

High

159340

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

159345

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.458

High

159358

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

159398

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.458

High

56563

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

159307

TOM70
Mitochondrial import receptor subunit TOM70

1

6

High-throughput

0.437

High

159311

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.437

High

159331

KS6B1
Ribosomal protein S6 kinase beta-1

1

3

Small-scale

0.437

High

159333

DNJB1
DnaJ homolog subfamily B member 1

1

6

High-throughput

0.437

High

159334

DNJA1
DnaJ homolog subfamily A member 1

1

7

High-throughput

0.437

High

159348

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.437

High

159360

SPAG1
Sperm-associated antigen 1

1

5

High-throughput

0.437

High

159377

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

1

High-throughput

0.437

High

159395

TTC1
Tetratricopeptide repeat protein 1

1

7

High-throughput

0.437

High

159397

TBA1C
Tubulin alpha-1C chain

1

4

High-throughput

0.437

High

159400

TBB2B
Tubulin beta-2B chain

1

2

High-throughput

0.437

High

159402

RPAP3
RNA polymerase II-associated protein 3

1

5

High-throughput

0.437

High

159415

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.437

High

159325

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

159380

SPC24
Kinetochore protein Spc24

3

0

High-throughput

0.347

High

159384

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.328

High

159385

CC107
Coiled-coil domain-containing protein 107

2

0

High-throughput

0.328

High

159372

HERC4
Probable E3 ubiquitin-protein ligase HERC4

2

0

High-throughput

0.318

High

159314

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.292

High

159298

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

159308

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.279

Low

159310

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

159374

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

0

High-throughput

0.279

Low

159390

TM169
Transmembrane protein 169

1

0

High-throughput

0.279

Low

159392

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

159417

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.279

Low

159418

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.279

Low

159378

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.269

Low

159324

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.268

Low

159300

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

159306

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.249

Low

159317

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

High-throughput

0.249

Low

159318

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.249

Low

159339

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

159344

TSP3
Thrombospondin-3

1

0

High-throughput

0.249

Low

159357

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.249

Low

159361

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.249

Low

159366

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

0

Small-scale

0.249

Low

159373

DDI2
Protein DDI1 homolog 2

1

0

High-throughput

0.249

Low

159389

KBP
KIF-binding protein

1

0

High-throughput

0.249

Low

159399

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.249

Low

159403

INO1
Inositol-3-phosphate synthase 1

1

0

High-throughput

0.249

Low

159406

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

159407

MTMR4
Myotubularin-related protein 4

1

0

High-throughput

0.249

Low

159408

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.249

Low

159413

TRM7
tRNA

1

0

High-throughput

0.249

Low

159321

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low

159411

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024