Protein: XRCC1
DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)

Gene: XRCC1
Organism: Homo sapiens
Interactions: 156
UniProt ID: P18887

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0001666 - response to hypoxia
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

417804

DPOLB
DNA polymerase beta

13

1

Small-scale

0.985

High

455075

PARP1
Poly [ADP-ribose] polymerase 1

10

3

Small-scale

0.972

High

579672

DNLI3
DNA ligase 3

13

0

Small-scale

0.929

High

523510

XRCC6
X-ray repair cross-complementing protein 6

3

0

High-throughput

0.816

High

579732

PNKP
Bifunctional polynucleotide phosphatase/kinase

9

2

Small-scale

0.755

High

579713

APTX
Aprataxin

6

1

Small-scale

0.747

High

579716

APLF
Aprataxin and PNK-like factor

7

0

Small-scale

0.719

High

579715

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

4

0

Small-scale

0.667

High

579746

TYDP1
Tyrosyl-DNA phosphodiesterase 1

4

0

Small-scale

0.664

High

517042

PCNA
Proliferating cell nuclear antigen

3

0

Small-scale

0.642

High

243909

BRD4
Bromodomain-containing protein 4

3

2

High-throughput

0.640

High

579687

H31
Histone H3.1

3

1

High-throughput

0.640

High

579661

APEX1
DNA repair nuclease/redox regulator APEX1

3

0

Small-scale

0.632

High

551913

RFA2
Replication protein A 32 kDa subunit

3

0

High-throughput

0.628

High

579753

DPOLL
DNA polymerase lambda

1

1

Small-scale

0.618

High

579660

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

0

Small-scale

0.613

High

391539

H2A1B
Histone H2A type 1-B/E

2

2

High-throughput

0.611

High

579720

H2B1A
Histone H2B type 1-A

2

2

High-throughput

0.611

High

579686

CSK21
Casein kinase II subunit alpha

2

0

Small-scale

0.606

High

331205

CHK2
Serine/threonine-protein kinase Chk2

1

0

Small-scale

0.593

High

579727

NEIL1
Endonuclease 8-like 1

2

0

Small-scale

0.592

High

579745

RN146
E3 ubiquitin-protein ligase RNF146

2

0

Small-scale

0.592

High

579747

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.586

High

579670

SOX2
Transcription factor SOX-2

2

1

High-throughput

0.584

High

579682

H2B1C
Histone H2B type 1-C/E/F/G/I

2

2

High-throughput

0.584

High

579684

UBC9
SUMO-conjugating enzyme UBC9

2

0

Small-scale

0.577

High

579656

XRCC1
DNA repair protein XRCC1

1

1

Small-scale

0.575

High

368956

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

579666

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

579688

PRKDC
DNA-dependent protein kinase catalytic subunit

2

0

Small-scale

0.559

High

579729

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.554

High

325028

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.547

High

579744

TOPRS
E3 ubiquitin-protein ligase Topors

1

0

Small-scale

0.537

High

579760

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.537

High

207886

XPOT
Exportin-T

1

1

High-throughput

0.536

High

470262

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

555287

H2AX
Histone H2AX

1

2

High-throughput

0.536

High

579677

DLX6
Homeobox protein DLX-6

1

1

High-throughput

0.536

High

579694

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

579709

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

579735

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

579741

FOXP1
Forkhead box protein P1

1

2

High-throughput

0.536

High

579755

FOXD3
Forkhead box protein D3

1

2

High-throughput

0.536

High

579679

MAX
Protein max

1

0

High-throughput

0.530

High

579707

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.515

High

579759

POLI
DNA polymerase iota

1

1

Small-scale

0.515

High

146796

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.513

High

157003

AIM2
Interferon-inducible protein AIM2

1

0

High-throughput

0.513

High

203499

PPIH
Peptidyl-prolyl cis-trans isomerase H

1

0

High-throughput

0.513

High

386065

P53
Cellular tumor antigen p53

1

0

Small-scale

0.513

High

508326

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

515550

SRF
Serum response factor

1

0

High-throughput

0.513

High

536471

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

556778

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

579675

BRPF1
Peregrin

1

0

High-throughput

0.513

High

579685

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.513

High

579689

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

579691

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

579693

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

579704

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

579714

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

579718

TBCK
TBC domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

579722

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.513

High

579728

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.513

High

579738

SSBP3
Single-stranded DNA-binding protein 3

1

0

High-throughput

0.513

High

579748

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

0

High-throughput

0.513

High

579754

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.513

High

579761

SF3B6
Splicing factor 3B subunit 6

1

0

High-throughput

0.513

High

579763

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

181950

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.504

High

579695

KLF10
Krueppel-like factor 10

1

1

High-throughput

0.500

High

579733

KLF6
Krueppel-like factor 6

1

1

High-throughput

0.500

High

579723

GCC1
GRIP and coiled-coil domain-containing protein 1

1

1

High-throughput

0.489

High

579737

DPH7
Diphthine methyltransferase

1

1

High-throughput

0.489

High

579668

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.479

High

162392

XPO1
Exportin-1

1

1

Small-scale

0.479

High

267883

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

411999

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

569158

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

579659

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

579669

NKX21
Homeobox protein Nkx-2.1

1

1

High-throughput

0.479

High

579671

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

579676

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

579690

H33
Histone H3.3

1

1

High-throughput

0.479

High

579706

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

579750

POLK
DNA polymerase kappa

1

1

Small-scale

0.479

High

579752

PARP2
Poly [ADP-ribose] polymerase 2

1

1

Small-scale

0.479

High

179540

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

233206

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

239300

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.458

High

264141

DPOLQ
DNA polymerase theta

1

0

Small-scale

0.458

High

359648

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

384237

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

431517

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.458

High

496264

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

579657

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

579658

CCNO
Cyclin-O

1

0

Small-scale

0.458

High

579662

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.458

High

579663

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

579665

MERL
Merlin

1

0

High-throughput

0.458

High

579667

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

579673

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

579674

RD23B
UV excision repair protein RAD23 homolog B

1

0

Small-scale

0.458

High

579680

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

579681

H4
Histone H4

1

0

High-throughput

0.458

High

579683

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

579692

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

579697

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

579698

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

579700

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

579701

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.458

High

579702

CUL1
Cullin-1

1

0

Small-scale

0.458

High

579708

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

579717

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

579724

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

579725

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

579726

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

579731

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

579734

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

579736

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

579751

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

579762

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

469943

H2AZ
Histone H2A.Z

1

3

Small-scale

0.445

High

579711

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

579749

GRHL1
Grainyhead-like protein 1 homolog

1

1

High-throughput

0.445

High

579719

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

579742

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

579758

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

579664

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

579703

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.426

High

376159

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

579764

PCDBB
Protocadherin beta-11

2

0

High-throughput

0.328

High

579721

RN166
E3 ubiquitin-protein ligase RNF166

2

0

High-throughput

0.318

High

579730

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.288

High

217630

EFNA2
Ephrin-A2

1

0

High-throughput

0.279

Low

315866

VNN1
Pantetheinase

1

0

High-throughput

0.279

Low

486225

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.279

Low

574236

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

579678

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.279

Low

579696

LIPA1
Liprin-alpha-1

1

0

High-throughput

0.279

Low

579699

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

579740

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

579743

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

579756

S39AA
Zinc transporter ZIP10

1

0

High-throughput

0.279

Low

100461

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

148382

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

277643

PRAF3
PRA1 family protein 3

1

0

Small-scale

0.249

Low

456801

FURIN
Furin

1

0

High-throughput

0.249

Low

579705

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

579712

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

579739

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

579757

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

56595

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

239765

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

579710

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024