Protein: DNLI3
DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)

Gene: DNLI3, LIG3
Organism: Homo sapiens
Interactions: 195
UniProt ID: P49916

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003677 - DNA binding
GO:0003909 - DNA ligase activity
GO:0003910 - DNA ligase (ATP) activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579672

XRCC1
DNA repair protein XRCC1

13

0

Small-scale

0.929

High

455223

PARP1
Poly [ADP-ribose] polymerase 1

5

4

Small-scale

0.926

High

523596

XRCC6
X-ray repair cross-complementing protein 6

4

6

Small-scale

0.911

High

524839

XRCC5
X-ray repair cross-complementing protein 5

1

6

Small-scale

0.724

High

552242

RFA2
Replication protein A 32 kDa subunit

5

1

High-throughput

0.714

High

836706

H31
Histone H3.1

5

2

High-throughput

0.702

High

836767

PNKP
Bifunctional polynucleotide phosphatase/kinase

4

3

Small-scale

0.701

High

836795

PARP2
Poly [ADP-ribose] polymerase 2

1

2

High-throughput

0.691

High

836748

APLF
Aprataxin and PNK-like factor

4

1

Small-scale

0.691

High

836789

TYDP1
Tyrosyl-DNA phosphodiesterase 1

4

0

Small-scale

0.670

High

417811

DPOLB
DNA polymerase beta

3

2

High-throughput

0.667

High

836758

H2B1A
Histone H2B type 1-A

3

4

High-throughput

0.667

High

836788

RN146
E3 ubiquitin-protein ligase RNF146

4

0

Small-scale

0.661

High

244124

BRD4
Bromodomain-containing protein 4

3

2

High-throughput

0.640

High

836703

H2B1C
Histone H2B type 1-C/E/F/G/I

3

4

High-throughput

0.640

High

555353

H2AX
Histone H2AX

2

4

High-throughput

0.628

High

836726

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.618

High

650682

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

0

Small-scale

0.613

High

391601

H2A1B
Histone H2A type 1-B/E

2

4

High-throughput

0.611

High

836723

TOP3A
DNA topoisomerase 3-alpha

2

1

High-throughput

0.611

High

836745

APTX
Aprataxin

2

3

Small-scale

0.611

High

836778

WDR76
WD repeat-containing protein 76

2

1

High-throughput

0.611

High

836760

NEIL1
Endonuclease 8-like 1

2

0

Small-scale

0.606

High

469968

H2AZ
Histone H2A.Z

2

4

Small-scale

0.601

High

836790

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.586

High

836739

PPCEL
Prolyl endopeptidase-like

2

0

High-throughput

0.585

High

836761

FMC1
Protein FMC1 homolog

2

0

High-throughput

0.585

High

836779

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

2

0

High-throughput

0.585

High

836780

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

2

0

High-throughput

0.585

High

836801

NUDC
Nuclear migration protein nudC

2

1

High-throughput

0.584

High

719980

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

836702

H4
Histone H4

2

0

High-throughput

0.559

High

401648

JUN
Transcription factor Jun

1

1

High-throughput

0.554

High

836699

MAX
Protein max

1

3

High-throughput

0.554

High

117044

KITM
Thymidine kinase 2, mitochondrial

1

1

High-throughput

0.536

High

126444

FOXE1
Forkhead box protein E1

1

5

High-throughput

0.536

High

157017

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

470301

H2A1
Histone H2A type 1

1

4

High-throughput

0.536

High

508398

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

536492

IRF2
Interferon regulatory factor 2

1

1

High-throughput

0.536

High

836710

FOXK2
Forkhead box protein K2

1

5

High-throughput

0.536

High

836714

EMX2
Homeobox protein EMX2

1

1

High-throughput

0.536

High

836717

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.536

High

836720

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.536

High

836737

H2A2C
Histone H2A type 2-C

1

4

High-throughput

0.536

High

836738

H2B2E
Histone H2B type 2-E

1

4

High-throughput

0.536

High

836742

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.536

High

836751

H2B3B
Histone H2B type 3-B

1

4

High-throughput

0.536

High

836768

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.536

High

836776

FOXP1
Forkhead box protein P1

1

4

High-throughput

0.536

High

836782

CBX8
Chromobox protein homolog 8

1

5

High-throughput

0.536

High

836786

TF7L2
Transcription factor 7-like 2

1

3

High-throughput

0.536

High

836796

FOXD3
Forkhead box protein D3

1

5

High-throughput

0.536

High

836797

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

1

High-throughput

0.536

High

836805

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.536

High

538156

ENPL
Endoplasmin

1

2

High-throughput

0.515

High

836734

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.515

High

71087

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

426603

H10
Histone H1.0

1

0

High-throughput

0.513

High

515569

SRF
Serum response factor

1

0

High-throughput

0.513

High

564836

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

785759

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

836695

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.513

High

836705

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.513

High

836707

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

836716

BAX
Apoptosis regulator BAX

1

0

High-throughput

0.513

High

836728

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

836732

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

836750

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.513

High

836753

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.513

High

836765

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.513

High

836770

MACD1
ADP-ribose glycohydrolase MACROD1

1

0

High-throughput

0.513

High

836775

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

836784

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.513

High

836800

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

Small-scale

0.513

High

679072

TLX1
T-cell leukemia homeobox protein 1

1

3

High-throughput

0.500

High

501838

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.493

High

836759

RN166
E3 ubiquitin-protein ligase RNF166

1

1

High-throughput

0.489

High

394349

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

798802

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.479

High

179581

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

226870

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

267957

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

317932

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

1

High-throughput

0.479

High

328775

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

337397

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.479

High

346246

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

377184

GCR
Glucocorticoid receptor

1

5

High-throughput

0.479

High

379133

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

384497

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

472830

H2AB2
Histone H2A-Bbd type 2/3

1

4

High-throughput

0.479

High

487238

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

500400

THA
Thyroid hormone receptor alpha

1

3

Small-scale

0.479

High

500470

THB
Thyroid hormone receptor beta

1

3

Small-scale

0.479

High

522860

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

High-throughput

0.479

High

532434

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

569397

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

631377

BRD2
Bromodomain-containing protein 2

1

3

High-throughput

0.479

High

652782

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

668523

PML
Protein PML

1

1

High-throughput

0.479

High

707557

H2B1B
Histone H2B type 1-B

1

4

High-throughput

0.479

High

740469

PPARG
Peroxisome proliferator-activated receptor gamma

1

4

Small-scale

0.479

High

799061

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

802536

CRK
Adapter molecule crk

1

1

High-throughput

0.479

High

817798

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

828173

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

836708

H33
Histone H3.3

1

2

High-throughput

0.479

High

836712

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

836718

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

836719

FOXC1
Forkhead box protein C1

1

5

High-throughput

0.479

High

836721

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

836722

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

836727

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

836731

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

836733

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

836735

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

836736

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

836744

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

836746

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

836749

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

836754

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

836757

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

836762

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

4

Small-scale

0.479

High

836764

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

836766

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

836785

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

836794

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

836804

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

148542

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

209783

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

233288

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

246191

NBN
Nibrin

1

0

Small-scale

0.458

High

278756

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

282048

CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

1

0

High-throughput

0.458

High

359765

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

386323

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

590724

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

624811

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

655272

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

High-throughput

0.458

High

684521

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

716884

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

719417

MERL
Merlin

1

0

High-throughput

0.458

High

770746

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.458

High

791384

HD
Huntingtin

1

0

Small-scale

0.458

High

836696

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

836697

EPHB4
Ephrin type-B receptor 4

1

0

High-throughput

0.458

High

836698

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.458

High

836700

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.458

High

836701

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

836709

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

836713

NUCB1
Nucleobindin-1

1

0

High-throughput

0.458

High

836715

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

836724

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

836730

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

836747

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

836756

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

836769

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

836771

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

836772

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

836774

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

836792

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

836803

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

414464

PRGR
Progesterone receptor

1

5

Small-scale

0.445

High

836725

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.445

High

836791

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

525867

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

836711

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

836755

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

836777

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

836799

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

217861

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

717568

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

836740

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

836802

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

836743

CLC4G
C-type lectin domain family 4 member G

1

2

Small-scale

0.407

High

261795

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

0

High-throughput

0.318

High

836763

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.288

High

364848

FRIL
Ferritin light chain

1

0

High-throughput

0.279

Low

591284

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

648478

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

836729

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

836752

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

836773

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

836787

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

836793

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.279

Low

64294

AN36A
Ankyrin repeat domain-containing protein 36A

1

0

High-throughput

0.249

Low

351993

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

456826

FURIN
Furin

1

0

High-throughput

0.249

Low

580961

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

High-throughput

0.249

Low

836704

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.249

Low

836741

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

836781

RHOF
Rho-related GTP-binding protein RhoF

1

0

High-throughput

0.249

Low

836798

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

56602

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

836783

PTPRH
Receptor-type tyrosine-protein phosphatase H

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024