Protein: DEN4C
DENN domain-containing protein 4C

Gene: DEN4C, DENND4C
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q5VZ89

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

914128

RB11A
Ras-related protein Rab-11A

2

6

High-throughput

0.754

High

683430

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.722

High

904696

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

927152

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.699

High

982122

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

909665

1433E
14-3-3 protein epsilon

4

5

High-throughput

0.694

High

646988

1433T
14-3-3 protein theta

3

20

High-throughput

0.667

High

120487

RHOD
Rho-related GTP-binding protein RhoD

1

18

High-throughput

0.618

High

591884

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.618

High

592309

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.618

High

844988

RAB7A
Ras-related protein Rab-7a

1

12

High-throughput

0.618

High

845535

RAB9A
Ras-related protein Rab-9A

1

19

High-throughput

0.618

High

895124

RAB2A
Ras-related protein Rab-2A

1

8

High-throughput

0.618

High

925348

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.618

High

1070243

RAB35
Ras-related protein Rab-35

1

11

High-throughput

0.618

High

1139609

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.618

High

1139618

DEN1A
DENN domain-containing protein 1A

1

5

High-throughput

0.618

High

1139636

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.618

High

1139653

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

4

High-throughput

0.618

High

507059

LAMP1
Lysosome-associated membrane glycoprotein 1

2

6

High-throughput

0.584

High

1139649

FBW1B
F-box/WD repeat-containing protein 11

2

4

High-throughput

0.584

High

272595

OFD1
Centriole and centriolar satellite protein OFD1

2

1

High-throughput

0.571

High

871609

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.536

High

1139613

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1139625

VPS35
Vacuolar protein sorting-associated protein 35

1

1

High-throughput

0.536

High

602851

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1139633

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

826291

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.489

High

116584

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

2

High-throughput

0.479

High

162853

XPO1
Exportin-1

1

4

High-throughput

0.479

High

166572

DCLK1
Serine/threonine-protein kinase DCLK1

1

3

High-throughput

0.479

High

178592

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

196454

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

3

High-throughput

0.479

High

205515

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

212869

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

216937

KIF1C
Kinesin-like protein KIF1C

1

6

High-throughput

0.479

High

237231

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

253362

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

High-throughput

0.479

High

264323

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.479

High

316256

NADK
NAD kinase

1

1

High-throughput

0.479

High

433823

LYN
Tyrosine-protein kinase Lyn

1

8

High-throughput

0.479

High

504228

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

508059

FGFR1
Fibroblast growth factor receptor 1

1

10

High-throughput

0.479

High

521995

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

527518

LAMP2
Lysosome-associated membrane glycoprotein 2

1

6

High-throughput

0.479

High

567109

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

598485

NF1
Neurofibromin

1

5

High-throughput

0.479

High

608008

FGFR4
Fibroblast growth factor receptor 4

1

10

High-throughput

0.479

High

673488

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.479

High

673592

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.479

High

684106

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

822052

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

835406

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.479

High

835819

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

880755

HDAC4
Histone deacetylase 4

1

6

High-throughput

0.479

High

912955

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

960378

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

974867

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

997169

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

2

High-throughput

0.479

High

1020177

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

6

High-throughput

0.479

High

1022404

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.479

High

1038454

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

1057172

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.479

High

1060544

ZN638
Zinc finger protein 638

1

2

High-throughput

0.479

High

1081508

NTRK3
NT-3 growth factor receptor

1

8

High-throughput

0.479

High

1136511

SPD2A
SH3 and PX domain-containing protein 2A

1

7

High-throughput

0.479

High

1139602

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1139604

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1139605

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.479

High

1139606

GGYF2
GRB10-interacting GYF protein 2

1

6

High-throughput

0.479

High

1139610

PHLB2
Pleckstrin homology-like domain family B member 2

1

3

High-throughput

0.479

High

1139611

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.479

High

1139612

KSR1
Kinase suppressor of Ras 1

1

5

High-throughput

0.479

High

1139614

RPTOR
Regulatory-associated protein of mTOR

1

3

High-throughput

0.479

High

1139617

F110B
Protein FAM110B

1

3

High-throughput

0.479

High

1139621

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1139623

GOGA1
Golgin subfamily A member 1

1

1

High-throughput

0.479

High

1139626

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

High-throughput

0.479

High

1139628

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1139629

F110A
Protein FAM110A

1

3

High-throughput

0.479

High

1139630

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.479

High

1139631

RTKN
Rhotekin

1

2

High-throughput

0.479

High

1139634

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.479

High

1139635

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1139640

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

3

High-throughput

0.479

High

1139643

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.479

High

1139644

CING
Cingulin

1

3

High-throughput

0.479

High

1139645

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1139646

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.479

High

1139647

NGAP
Ras GTPase-activating protein nGAP

1

5

High-throughput

0.479

High

1139648

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1139651

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1139654

GAB2
GRB2-associated-binding protein 2

1

7

High-throughput

0.479

High

1139655

LAMP3
Lysosome-associated membrane glycoprotein 3

1

6

High-throughput

0.479

High

1139656

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1139657

STA13
StAR-related lipid transfer protein 13

1

5

High-throughput

0.479

High

1139658

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

High-throughput

0.479

High

232904

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

375753

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.458

High

430218

PROF1
Profilin-1

1

0

High-throughput

0.458

High

1129555

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

56638

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

5

High-throughput

0.445

High

483937

CALM1
Calmodulin-1

1

6

High-throughput

0.445

High

484012

CALM2
Calmodulin-2

1

6

High-throughput

0.445

High

484143

CALM3
Calmodulin-3

1

6

High-throughput

0.445

High

230880

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

5

High-throughput

0.437

High

552929

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

673280

WEE1
Wee1-like protein kinase

1

2

High-throughput

0.437

High

1076874

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

6

High-throughput

0.437

High

1136453

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

4

High-throughput

0.437

High

1139603

AN34A
Ankyrin repeat domain-containing protein 34A

1

4

High-throughput

0.437

High

1139607

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1139608

SYDE1
Rho GTPase-activating protein SYDE1

1

7

High-throughput

0.437

High

1139616

NAV1
Neuron navigator 1

1

3

High-throughput

0.437

High

1139619

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

8

High-throughput

0.437

High

1139620

SRS12
Serine/arginine-rich splicing factor 12

1

2

High-throughput

0.437

High

1139622

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.437

High

1139627

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.437

High

1139632

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.437

High

1139637

TANC2
Protein TANC2

1

2

High-throughput

0.437

High

1139639

KI13B
Kinesin-like protein KIF13B

1

6

High-throughput

0.437

High

1139642

FA53C
Protein FAM53C

1

1

High-throughput

0.437

High

1139650

RCOR1
REST corepressor 1

1

1

High-throughput

0.437

High

1139652

PPM1H
Protein phosphatase 1H

1

3

High-throughput

0.437

High

529246

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1139641

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.279

Low

132500

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

232232

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

1139624

PF21A
PHD finger protein 21A

1

0

High-throughput

0.249

Low

1139638

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

1139615

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024