Protein: PRKN
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase)

Gene: PRKN
Organism: Mus musculus
Interactions: 40
UniProt ID: Q9WVS6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0000266 - mitochondrial fission

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1143927

SH3G2
Endophilin-A1

1

18

Small-scale

0.770

High

932611

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

1351665

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

18

Small-scale

0.647

High

251109

CSKP
Peripheral plasma membrane protein CASK

1

20

Small-scale

0.618

High

337640

ABL1
Tyrosine-protein kinase ABL1

1

11

Small-scale

0.618

High

814062

MK14
Mitogen-activated protein kinase 14

1

11

Small-scale

0.618

High

1143919

SH3G1
Endophilin-A2

1

18

Small-scale

0.618

High

1143930

SH3G3
Endophilin-A3

1

17

Small-scale

0.618

High

1206619

FBXW8
F-box/WD repeat-containing protein 8

1

20

Small-scale

0.618

High

1307874

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

Small-scale

0.618

High

1322336

RBP2
E3 SUMO-protein ligase RanBP2

1

7

Small-scale

0.618

High

1376742

HDAC6
Histone deacetylase 6

1

17

Small-scale

0.618

High

1193518

MFN2
Mitofusin-2

2

6

Small-scale

0.611

High

291973

BECN1
Beclin-1

2

3

Small-scale

0.584

High

1207892

Q8C1W2
Galectin

2

6

Small-scale

0.584

High

88466

D3Z656
phosphoinositide 5-phosphatase

1

10

Small-scale

0.561

High

992064

BAX
Apoptosis regulator BAX

1

9

Small-scale

0.561

High

1246904

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

13

Small-scale

0.561

High

788009

EPS15
Epidermal growth factor receptor substrate 15

1

20

Small-scale

0.501

High

1153536

CHSS2
Chondroitin sulfate synthase 2

1

2

Small-scale

0.494

High

57127

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

20

Small-scale

0.479

High

139714

PRDX6
Peroxiredoxin-6

1

15

Small-scale

0.479

High

192257

PHB2
Prohibitin-2

1

7

Small-scale

0.479

High

356897

P53
Cellular tumor antigen p53

1

10

Small-scale

0.479

High

489505

BCL2
Apoptosis regulator Bcl-2

1

9

Small-scale

0.479

High

619105

IRF8
Interferon regulatory factor 8

1

5

High-throughput

0.479

High

761223

GRIK2
Glutamate receptor ionotropic, kainate 2

1

11

Small-scale

0.479

High

776586

SYT4
Synaptotagmin-4

1

9

Small-scale

0.479

High

835152

CAV1
Caveolin-1

1

4

Small-scale

0.479

High

873173

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

6

Small-scale

0.479

High

892218

ACTB
Actin, cytoplasmic 1

1

13

Small-scale

0.479

High

933097

ACTS
Actin, alpha skeletal muscle

1

12

Small-scale

0.479

High

935714

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

1112183

ZN746
Zinc finger protein 746

1

13

Small-scale

0.479

High

1141478

ZBT17
Zinc finger and BTB domain-containing protein 17

1

11

Small-scale

0.479

High

1143065

HS71A
Heat shock 70 kDa protein 1A

1

12

Small-scale

0.479

High

1322079

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

8

Small-scale

0.479

High

139803

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

9

High-throughput

0.445

High

222606

IKBE
NF-kappa-B inhibitor epsilon

1

20

High-throughput

0.445

High

1351683

B9D1
B9 domain-containing protein 1

1

1

Small-scale

0.445

High


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Last updated: 15 Jul 2024