Protein: KLH12
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)

Gene: KLH12, KLHL12
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q53G59

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0006513 - protein monoubiquitination
GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0014029 - neural crest formation
GO:0014032 - neural crest cell development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1041712

CUL3
Cullin-3

16

20

Small-scale

0.988

High

1120764

KLH12
Kelch-like protein 12

8

19

Small-scale

0.973

High

307182

KLHL2
Kelch-like protein 2

8

19

Small-scale

0.968

High

1120825

FXL17
F-box/LRR-repeat protein 17

6

16

Small-scale

0.957

High

1120826

KLHL3
Kelch-like protein 3

4

19

High-throughput

0.895

High

1120769

KLH24
Kelch-like protein 24

3

19

High-throughput

0.836

High

1120765

KLH26
Kelch-like protein 26

4

19

Small-scale

0.788

High

1120823

PEF1
Peflin

7

3

Small-scale

0.753

High

1120820

ZBTB4
Zinc finger and BTB domain-containing protein 4

2

0

High-throughput

0.742

High

1041022

CUL1
Cullin-1

2

20

Small-scale

0.737

High

803568

BAG6
Large proline-rich protein BAG6

5

2

Small-scale

0.723

High

1120796

DVL3
Segment polarity protein dishevelled homolog DVL-3

5

13

Small-scale

0.717

High

132884

SDCB1
Syntenin-1

4

6

High-throughput

0.707

High

1120801

NTAQ1
Protein N-terminal glutamine amidohydrolase

4

3

High-throughput

0.707

High

302293

SC31A
Protein transport protein Sec31A

4

1

Small-scale

0.703

High

781380

BCL6
B-cell lymphoma 6 protein

2

1

High-throughput

0.700

High

259742

PDCD6
Programmed cell death protein 6

3

3

Small-scale

0.678

High

1120819

PRR13
Proline-rich protein 13

4

0

High-throughput

0.675

High

303751

INMT
Indolethylamine N-methyltransferase

3

2

High-throughput

0.675

High

452435

PGFRB
Platelet-derived growth factor receptor beta

3

2

High-throughput

0.675

High

598153

FLNA
Filamin-A

3

1

High-throughput

0.675

High

958815

EM55
55 kDa erythrocyte membrane protein

3

2

High-throughput

0.675

High

1120782

TB10C
Carabin

3

1

High-throughput

0.675

High

1120786

Q8N4I8
KLHL3 protein

1

19

High-throughput

0.665

High

878189

SEC13
Protein SEC13 homolog

3

2

Small-scale

0.656

High

1049221

KEAP1
Kelch-like ECH-associated protein 1

1

20

Small-scale

0.647

High

1120767

TTBK2
Tau-tubulin kinase 2

3

0

High-throughput

0.646

High

1120776

SNX20
Sorting nexin-20

4

3

High-throughput

0.644

High

868528

ATX1
Ataxin-1

2

4

High-throughput

0.643

High

150714

DVL1
Segment polarity protein dishevelled homolog DVL-1

2

8

Small-scale

0.629

High

151017

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

8

Small-scale

0.624

High

1120771

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

3

3

High-throughput

0.616

High

1120809

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

5

High-throughput

0.616

High

299386

UBXN7
UBX domain-containing protein 7

2

3

High-throughput

0.611

High

1120791

LNX1
E3 ubiquitin-protein ligase LNX

3

7

High-throughput

0.609

High

1120787

ARRD1
Arrestin domain-containing protein 1

3

3

High-throughput

0.607

High

1044775

RIN1
Ras and Rab interactor 1

2

1

High-throughput

0.606

High

1076961

MARE1
Microtubule-associated protein RP/EB family member 1

2

2

High-throughput

0.606

High

1120774

CSN6
COP9 signalosome complex subunit 6

2

8

High-throughput

0.601

High

1120793

CSN5
COP9 signalosome complex subunit 5

2

10

High-throughput

0.601

High

834227

VEGFB
Vascular endothelial growth factor B

3

1

High-throughput

0.597

High

1120815

PKHA4
Pleckstrin homology domain-containing family A member 4

3

1

High-throughput

0.596

High

164915

SC16A
Protein transport protein Sec16A

2

2

Small-scale

0.584

High

475860

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

9

Small-scale

0.584

High

1073959

SC23A
Protein transport protein Sec23A

2

2

Small-scale

0.584

High

1074043

SC23B
Protein transport protein Sec23B

2

2

Small-scale

0.584

High

930247

UBC9
SUMO-conjugating enzyme UBC9

2

10

High-throughput

0.584

High

1109706

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

2

0

High-throughput

0.580

High

1043391

CUL4B
Cullin-4B

1

20

High-throughput

0.575

High

1057223

KCTD2
BTB/POZ domain-containing protein KCTD2

1

3

High-throughput

0.575

High

1120821

KLHL9
Kelch-like protein 9

1

19

High-throughput

0.575

High

1120822

KLH13
Kelch-like protein 13

1

19

High-throughput

0.575

High

1120827

KLH21
Kelch-like protein 21

1

19

High-throughput

0.575

High

1120830

KLH20
Kelch-like protein 20

1

20

High-throughput

0.575

High

1120777

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

3

High-throughput

0.573

High

1120832

ARI1
E3 ubiquitin-protein ligase ARIH1

2

12

High-throughput

0.571

High

1120794

FUBP2
Far upstream element-binding protein 2

1

2

Small-scale

0.561

High

1120770

CRTC3
CREB-regulated transcription coactivator 3

1

1

High-throughput

0.560

High

1120773

Q7KZS0
SUMO-conjugating enzyme UBC9

2

11

High-throughput

0.558

High

940987

RNF4
E3 ubiquitin-protein ligase RNF4

2

1

High-throughput

0.553

High

1120789

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

2

High-throughput

0.553

High

1120784

GLCTK
Glycerate kinase

1

0

High-throughput

0.549

High

154981

NDC80
Kinetochore protein NDC80 homolog

1

3

High-throughput

0.541

High

488741

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.541

High

1120817

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

1

High-throughput

0.541

High

1120828

TAOK2
Serine/threonine-protein kinase TAO2

1

5

High-throughput

0.541

High

928937

SKP1
S-phase kinase-associated protein 1

1

4

High-throughput

0.536

High

979308

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.536

High

1079516

NEDD8
NEDD8

1

1

High-throughput

0.536

High

1120780

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

1120800

DCNL1
DCN1-like protein 1

1

9

High-throughput

0.536

High

1120803

SCYL1
N-terminal kinase-like protein

1

4

High-throughput

0.536

High

1120834

TACC3
Transforming acidic coiled-coil-containing protein 3

1

7

High-throughput

0.536

High

1120785

SYNE4
Nesprin-4

1

1

High-throughput

0.523

High

1120783

NUDC3
NudC domain-containing protein 3

2

20

Small-scale

0.521

High

771999

VHL
von Hippel-Lindau disease tumor suppressor

1

4

High-throughput

0.515

High

791624

HD
Huntingtin

1

2

High-throughput

0.515

High

1120779

Q86TH3
Dishevelled, dsh homolog 1

1

7

High-throughput

0.515

High

89968

D6R9G5
Kelch like family member 2

1

19

High-throughput

0.514

High

1120768

KLH17
Kelch-like protein 17

1

19

High-throughput

0.514

High

1120833

IPP
Actin-binding protein IPP

1

19

High-throughput

0.514

High

650099

CO8A1
Collagen alpha-1(VIII) chain

1

5

High-throughput

0.494

High

1084475

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

High-throughput

0.494

High

658375

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.493

High

990782

COGA1

1

4

High-throughput

0.489

High

1120798

MED12
Mediator of RNA polymerase II transcription subunit 12

1

4

High-throughput

0.489

High

1120812

ZBP1
Z-DNA-binding protein 1

1

1

High-throughput

0.481

High

315715

SC24B
Protein transport protein Sec24B

1

2

Small-scale

0.479

High

374332

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

685976

ARRB2
Beta-arrestin-2

1

1

Small-scale

0.479

High

827218

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.479

High

896117

UBC12
NEDD8-conjugating enzyme Ubc12

1

14

High-throughput

0.479

High

1120792

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1120797

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

5

Small-scale

0.479

High

1120835

S23IP
SEC23-interacting protein

1

1

Small-scale

0.479

High

1080007

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.470

High

57973

A2RRL9
Z-DNA binding protein 1

1

1

High-throughput

0.470

High

358636

CO3A1

1

4

High-throughput

0.470

High

1089322

Q17RA1
Caspase recruitment domain family, member 10

1

4

High-throughput

0.470

High

1120775

Q7LAP4
Vascular endothelial growth factor B

1

1

High-throughput

0.470

High

1120802

MY15B
Unconventional myosin-XVB

1

5

High-throughput

0.470

High

815886

MTR1A
Melatonin receptor type 1A

1

3

High-throughput

0.464

High

1068199

PEA15
Astrocytic phosphoprotein PEA-15

1

0

Small-scale

0.460

High

1120766

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.458

High

1120818

RNC
Ribonuclease 3

1

0

High-throughput

0.458

High

988923

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

897257

CSN2
COP9 signalosome complex subunit 2

1

17

High-throughput

0.445

High

1024168

CSN1
COP9 signalosome complex subunit 1

1

13

High-throughput

0.445

High

1120805

NUDC1
NudC domain-containing protein 1

1

2

High-throughput

0.445

High

1120807

CSN4
COP9 signalosome complex subunit 4

1

3

High-throughput

0.445

High

1120811

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

9

High-throughput

0.445

High

1120814

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

9

High-throughput

0.445

High

1120824

CSN7A
COP9 signalosome complex subunit 7a

1

3

High-throughput

0.445

High

1120829

CSN3
COP9 signalosome complex subunit 3

1

15

High-throughput

0.445

High

1120808

CAR10
Caspase recruitment domain-containing protein 10

1

6

High-throughput

0.439

High

1120795

RIT1
GTP-binding protein Rit1

1

1

Small-scale

0.437

High

1120799

FBX17
F-box only protein 17

1

0

High-throughput

0.426

High

1120804

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

1120810

LNP
Endoplasmic reticulum junction formation protein lunapark

5

0

Small-scale

0.375

High

602200

DRD4
D(4) dopamine receptor

5

0

Small-scale

0.370

High

1120788

RP25L
Ribonuclease P protein subunit p25-like protein

3

0

High-throughput

0.352

High

1120772

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.316

High

1120781

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1120806

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

0

High-throughput

0.316

High

1120778

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.299

High

1048693

DGCR6
Protein DGCR6

1

0

High-throughput

0.282

High

1120813

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.282

High

718911

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

1120790

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1120816

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low

1120831

SPEF1
Sperm flagellar protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024