Protein: APH1A
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)

Gene: APH1A
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q96BI3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001656 - metanephros development
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834327

PSN1
Presenilin-1

7

10

Small-scale

0.961

High

834998

PSN2
Presenilin-2

3

10

Small-scale

0.839

High

1266753

NICA
Nicastrin

10

6

Small-scale

0.751

High

1285543

PEN2
Gamma-secretase subunit PEN-2

7

3

Small-scale

0.740

High

1285537

FXYD6
FXYD domain-containing ion transport regulator 6

2

1

High-throughput

0.606

High

1285540

S39A9
Zinc transporter ZIP9

2

1

High-throughput

0.606

High

58316

TM218
Transmembrane protein 218

2

0

High-throughput

0.580

High

207473

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.580

High

396395

APOD
Apolipoprotein D

2

0

High-throughput

0.580

High

426793

ASGR1
Asialoglycoprotein receptor 1

2

0

High-throughput

0.580

High

958838

EM55
55 kDa erythrocyte membrane protein

2

0

High-throughput

0.580

High

1012194

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.580

High

1170381

MFSD6
Major facilitator superfamily domain-containing protein 6

2

0

High-throughput

0.580

High

1202950

ANR46
Ankyrin repeat domain-containing protein 46

2

0

High-throughput

0.580

High

1285536

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.580

High

1285541

TM140
Transmembrane protein 140

2

0

High-throughput

0.580

High

1285545

FIS1
Mitochondrial fission 1 protein

2

0

High-throughput

0.580

High

1285546

SERP1
Stress-associated endoplasmic reticulum protein 1

2

0

High-throughput

0.580

High

1160164

S39A4
Zinc transporter ZIP4

1

1

High-throughput

0.536

High

1285538

SNX25
Sorting nexin-25

1

1

High-throughput

0.536

High

793753

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.529

High

537299

DRD2
D(2) dopamine receptor

1

0

High-throughput

0.518

High

1285539

GPR35
G-protein coupled receptor 35

1

0

High-throughput

0.518

High

61059

A5PKU2
TUSC5 protein

1

3

High-throughput

0.515

High

395423

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

1237722

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.513

High

412297

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

896799

ARP3
Actin-related protein 3

1

0

High-throughput

0.493

High

1074110

CYH1
Cytohesin-1

1

0

High-throughput

0.493

High

1266781

SNX19
Sorting nexin-19

1

1

High-throughput

0.489

High

216793

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.486

High

1054242

HES1
Transcription factor HES-1

1

1

High-throughput

0.481

High

1220522

TARG1
Trafficking regulator of GLUT4 1

1

3

High-throughput

0.481

High

299966

ERLN2
Erlin-2

1

1

Small-scale

0.479

High

1165833

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1285535

APH1A
Gamma-secretase subunit APH-1A

1

0

Small-scale

0.458

High

146533

BHE40
Class E basic helix-loop-helix protein 40

1

1

High-throughput

0.439

High

980635

TLE1
Transducin-like enhancer protein 1

1

2

High-throughput

0.439

High

623661

IBP5
Insulin-like growth factor-binding protein 5

2

0

High-throughput

0.316

High

883772

SCND1
SCAN domain-containing protein 1

2

0

High-throughput

0.316

High

1285542

S38A7
Sodium-coupled neutral amino acid transporter 7

2

0

High-throughput

0.316

High

579277

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.282

High

157987

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.251

Low

198949

RFOX2
RNA binding protein fox-1 homolog 2

1

0

High-throughput

0.251

Low

550427

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.251

Low

770723

TPO
Thrombopoietin

1

0

High-throughput

0.251

Low

1285544

GPTC8
G patch domain-containing protein 8

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024