Protein: ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)

Gene: ODPB, PDHB
Organism: Homo sapiens
Interactions: 209
UniProt ID: P11177

Gene Ontology (top 5):
GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440314

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

8

15

Small-scale

0.970

High

489688

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

5

8

Small-scale

0.929

High

126214

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

4

8

Small-scale

0.892

High

452590

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

4

3

High-throughput

0.699

High

505830

PDK1
[Pyruvate dehydrogenase

4

6

High-throughput

0.686

High

505785

STA5A
Signal transducer and activator of transcription 5A

3

1

High-throughput

0.675

High

505762

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

3

5

High-throughput

0.667

High

505793

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

3

5

High-throughput

0.667

High

505807

CANB1
Calcineurin subunit B type 1

3

1

High-throughput

0.667

High

505812

PP2BA
Protein phosphatase 3 catalytic subunit alpha

3

5

High-throughput

0.667

High

505831

PDK2
[Pyruvate dehydrogenase

3

6

High-throughput

0.667

High

505832

PDK3
[Pyruvate dehydrogenase

3

6

High-throughput

0.667

High

505823

FHL2
Four and a half LIM domains protein 2

3

0

High-throughput

0.638

High

505858

BANP
Protein BANP

3

0

High-throughput

0.638

High

496168

TAU
Microtubule-associated protein tau

2

7

High-throughput

0.628

High

505815

FOXD4
Forkhead box protein D4

2

1

High-throughput

0.628

High

505775

AKT1
RAC-alpha serine/threonine-protein kinase

2

3

High-throughput

0.614

High

505820

CUL3
Cullin-3

2

2

High-throughput

0.611

High

505841

DUS29
Dual specificity phosphatase 29

2

0

High-throughput

0.595

High

345784

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

505791

YAP1
Transcriptional coactivator YAP1

2

4

Small-scale

0.584

High

505796

PPT1
Palmitoyl-protein thioesterase 1

2

1

Small-scale

0.584

High

505867

TRI63
E3 ubiquitin-protein ligase TRIM63

2

3

Small-scale

0.584

High

505773

ODPAT
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

1

15

Small-scale

0.575

High

373595

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

2

High-throughput

0.571

High

505767

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

505904

ECT2
Protein ECT2

2

0

High-throughput

0.559

High

505888

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

3

High-throughput

0.555

High

505799

RBM11
Splicing regulator RBM11

1

1

High-throughput

0.541

High

128410

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.536

High

505761

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

505768

VDAC1
Voltage-dependent anion-selective channel protein 1

1

2

High-throughput

0.536

High

505774

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

505781

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

7

High-throughput

0.536

High

505797

STA5B
Signal transducer and activator of transcription 5B

1

1

High-throughput

0.536

High

505849

COX15
Heme A synthase COX15

1

1

High-throughput

0.536

High

505879

PARK7
Parkinson disease protein 7

1

2

High-throughput

0.536

High

505918

HDAC6
Histone deacetylase 6

1

3

High-throughput

0.536

High

505922

HECD1
E3 ubiquitin-protein ligase HECTD1

2

2

High-throughput

0.533

High

505784

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

343938

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

505852

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

505928

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

505766

ANXA7
Annexin A7

1

2

High-throughput

0.508

High

505833

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.508

High

505759

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.494

High

505771

AA2AR
Adenosine receptor A2a

1

1

High-throughput

0.494

High

505806

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.494

High

362746

FINC
Fibronectin

1

1

High-throughput

0.489

High

505779

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.489

High

505875

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.489

High

505764

RCC1
Regulator of chromosome condensation

1

0

High-throughput

0.486

High

505782

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

505880

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

Small-scale

0.481

High

209618

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

264820

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

269971

RF1M
Peptide chain release factor 1, mitochondrial

1

3

High-throughput

0.479

High

294302

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

304004

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

336834

OTC
Ornithine transcarbamylase, mitochondrial

1

2

High-throughput

0.479

High

377053

GCR
Glucocorticoid receptor

1

2

Small-scale

0.479

High

503319

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

505763

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

505770

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

505772

PML
Protein PML

1

4

High-throughput

0.479

High

505776

AKT2
RAC-beta serine/threonine-protein kinase

1

4

High-throughput

0.479

High

505777

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

505780

BASI
Basigin

1

2

High-throughput

0.479

High

505783

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

505788

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

505789

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

505794

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

505795

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

505800

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

505802

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

505803

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

505804

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

505805

RHOB
Rho-related GTP-binding protein RhoB

1

2

High-throughput

0.479

High

505810

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

505813

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

505814

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

505816

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

505817

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

505818

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

4

High-throughput

0.479

High

505819

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

505821

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

505822

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

505826

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

505827

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

505834

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

505836

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.479

High

505843

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

505847

MOB2
MOB kinase activator 2

1

1

High-throughput

0.479

High

505850

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

505851

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

505853

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.479

High

505855

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

505862

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

505863

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

3

Small-scale

0.479

High

505865

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

505866

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.479

High

505868

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

505871

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

505876

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

505878

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

505881

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

505886

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

505887

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

505891

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

505894

MTRFR
Mitochondrial translation release factor in rescue

1

3

High-throughput

0.479

High

505895

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

505901

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

505903

AKTIP
AKT-interacting protein

1

2

Small-scale

0.479

High

505905

BRF2
Transcription factor IIIB 50 kDa subunit

1

1

High-throughput

0.479

High

505906

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

505907

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

505909

ANLN
Anillin

1

1

High-throughput

0.479

High

505911

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

2

Small-scale

0.479

High

505919

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

3

High-throughput

0.479

High

505920

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

505924

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

505925

SRRM2
Serine/arginine repetitive matrix protein 2

1

2

High-throughput

0.479

High

59096

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

63278

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.458

High

119116

LEG9
Galectin-9

1

0

High-throughput

0.458

High

326400

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

327342

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

428894

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

429810

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

505778

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

505787

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

505809

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

505811

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

505824

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

505829

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

505835

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

505838

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

505842

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

505861

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

505869

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

505870

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

505874

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

505882

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

505883

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

505885

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

505889

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

505892

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

505893

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

505897

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

505899

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

505900

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

505902

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

505908

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.458

High

505912

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

505913

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

505914

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

505915

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

505916

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

505921

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

505927

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

81547

B7Z207
Protein-serine/threonine kinase

1

6

High-throughput

0.445

High

401311

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

505760

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

505765

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.445

High

505837

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

505890

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.445

High

505929

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

148329

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

172969

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.437

High

196258

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

322114

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.437

High

351706

SOMA
Somatotropin

1

1

High-throughput

0.437

High

384165

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

505769

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.437

High

505790

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.437

High

505798

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.437

High

505808

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

505840

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

505844

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

505845

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

505854

GID4
Glucose-induced degradation protein 4 homolog

1

1

High-throughput

0.437

High

505864

RND1
Rho-related GTP-binding protein Rho6

1

3

High-throughput

0.437

High

505872

KCD12
BTB/POZ domain-containing protein KCTD12

1

2

Small-scale

0.437

High

505896

RHOJ
Rho-related GTP-binding protein RhoJ

1

3

High-throughput

0.437

High

505898

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

505910

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

505917

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.437

High

505786

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

505848

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.426

High

505859

POC5
Centrosomal protein POC5

1

0

High-throughput

0.426

High

305926

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.407

High

505839

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.407

High

505846

NEK10
Serine/threonine-protein kinase Nek10

1

6

High-throughput

0.407

High

505860

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

505877

CK5P2
CDK5 regulatory subunit-associated protein 2

1

4

High-throughput

0.407

High

505926

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

403750

ITB1
Integrin beta-1

1

0

High-throughput

0.282

High

197205

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

505792

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

505873

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

147482

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.269

Low

245939

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

505801

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.265

Low

505825

GRB7
Growth factor receptor-bound protein 7

1

0

High-throughput

0.265

Low

505828

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

505856

MILK2
MICAL-like protein 2

1

0

High-throughput

0.249

Low

505857

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low

505884

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.249

Low

505923

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024