Protein: KAD4
Adenylate kinase 4, mitochondrial (AK 4) (EC 2.7.4.10) (EC 2.7.4.6) (Adenylate kinase 3-like) (GTP:AMP phosphotransferase AK4)

Gene: KAD4, AK4
Organism: Homo sapiens
Interactions: 142
UniProt ID: P27144

Gene Ontology (top 5):
GO:0002082 - regulation of oxidative phosphorylation
GO:0004017 - adenylate kinase activity
GO:0004550 - nucleoside diphosphate kinase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

646409

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

646377

IF2M
Translation initiation factor IF-2, mitochondrial

2

1

High-throughput

0.611

High

646458

MTG2
Mitochondrial ribosome-associated GTPase 2

2

1

High-throughput

0.611

High

528240

CCL5
C-C motif chemokine 5

2

0

High-throughput

0.602

High

59113

VWA8
von Willebrand factor A domain-containing protein 8

2

0

High-throughput

0.585

High

262716

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

646369

T2EB
Transcription initiation factor IIE subunit beta

2

1

High-throughput

0.574

High

157294

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

4

High-throughput

0.536

High

276688

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

1

1

High-throughput

0.536

High

300718

GLSK
Glutaminase kidney isoform, mitochondrial

1

2

High-throughput

0.536

High

398227

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

1

High-throughput

0.536

High

452634

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

513533

PYC
Pyruvate carboxylase, mitochondrial

1

1

High-throughput

0.536

High

520690

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

5

High-throughput

0.536

High

611985

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.536

High

646371

AL4A1
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

646372

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

2

High-throughput

0.536

High

646401

SYLM
Leucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

646405

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

1

High-throughput

0.536

High

646408

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

4

High-throughput

0.536

High

646415

SYVM
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

646418

ACD10
Acyl-CoA dehydrogenase family member 10

1

1

High-throughput

0.536

High

646423

SYPM
Probable proline--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

646432

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

1

1

High-throughput

0.536

High

646434

NSUN4
5-methylcytosine rRNA methyltransferase NSUN4

1

1

High-throughput

0.536

High

646435

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.536

High

646437

ECHD3
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial

1

1

High-throughput

0.536

High

646451

SYTM
Threonine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

646463

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

1

High-throughput

0.536

High

646467

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

1

High-throughput

0.536

High

646370

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.518

High

646441

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.518

High

63291

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.513

High

127454

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

167205

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.513

High

254669

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

398325

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

574244

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

602954

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.513

High

620656

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

646382

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.513

High

646383

FGF12
Fibroblast growth factor 12

1

0

High-throughput

0.513

High

646410

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.513

High

646419

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.513

High

646420

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

646425

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.513

High

646428

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

646436

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

646439

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.513

High

646440

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.513

High

646444

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.513

High

646445

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

646464

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.513

High

646474

SARDH
Sarcosine dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

646477

MTO1
Protein MTO1 homolog, mitochondrial

1

0

High-throughput

0.513

High

646478

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

646479

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.513

High

646480

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

394152

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

646381

CNN1
Calponin-1

1

1

High-throughput

0.489

High

646386

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

1

High-throughput

0.489

High

646389

CAV1
Caveolin-1

1

2

High-throughput

0.489

High

646406

PPCEL
Prolyl endopeptidase-like

1

1

High-throughput

0.489

High

646416

SYT6
Synaptotagmin-6

1

1

High-throughput

0.489

High

646421

T184A
Transmembrane protein 184A

1

1

High-throughput

0.489

High

646429

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

High-throughput

0.489

High

646481

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

646399

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.486

High

264843

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

269984

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

337968

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

373713

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

440351

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.479

High

499547

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

646373

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

646374

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

646376

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

646384

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

646394

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

646395

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

646396

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

646397

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

646398

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

646402

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.479

High

646404

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.479

High

646411

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

646413

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

1

Small-scale

0.479

High

646417

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

646422

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

646424

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

4

High-throughput

0.479

High

646426

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

646433

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.479

High

646443

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

646450

TR61B
tRNA

1

1

High-throughput

0.479

High

646457

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

646459

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

646462

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

646466

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

646470

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

4

High-throughput

0.479

High

646472

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

646473

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

327362

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

486464

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

646375

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

646379

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

646385

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

646391

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

646392

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

646400

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

646438

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

646447

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

646449

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

646452

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

646454

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

646455

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

646456

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

646461

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

646468

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

646471

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

646387

E2F1
Transcription factor E2F1

1

1

High-throughput

0.445

High

646388

TAGL
Transgelin

1

1

High-throughput

0.445

High

646414

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

646475

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

646412

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

1

High-throughput

0.437

High

646446

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

3

0

High-throughput

0.347

High

646430

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.328

High

321971

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

646378

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.279

Low

646380

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

646390

COAA1

1

0

High-throughput

0.279

Low

646393

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low

646407

UNC50
Protein unc-50 homolog

1

0

High-throughput

0.279

Low

646427

NIPA2
Magnesium transporter NIPA2

1

0

High-throughput

0.279

Low

646431

AP2B
Transcription factor AP-2-beta

1

0

High-throughput

0.279

Low

646442

FMNL2
Formin-like protein 2

1

0

High-throughput

0.279

Low

646453

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

646460

GSX1
GS homeobox 1

1

0

High-throughput

0.279

Low

646465

CENPM
Centromere protein M

1

0

High-throughput

0.279

Low

646469

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

646476

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

646403

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.269

Low

646448

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024