Protein: ODO1
2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)

Gene: ODO1, OGDH
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q02218

Gene Ontology (top 5):
GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006091 - generation of precursor metabolites and energy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452744

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

4

7

Small-scale

0.696

High

969558

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

6

High-throughput

0.691

High

739076

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

13

Small-scale

0.647

High

440473

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

5

High-throughput

0.618

High

969480

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.618

High

969499

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

3

High-throughput

0.611

High

969555

HDAC6
Histone deacetylase 6

2

1

High-throughput

0.611

High

969505

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

2

1

Small-scale

0.601

High

969472

GRSF1
G-rich sequence factor 1

2

6

High-throughput

0.584

High

969484

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

969504

ESR2
Estrogen receptor beta

2

4

High-throughput

0.571

High

528994

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.552

High

369435

ESR1
Estrogen receptor

1

4

High-throughput

0.536

High

947805

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

2

High-throughput

0.536

High

969483

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

969500

TCAIM
T-cell activation inhibitor, mitochondrial

1

1

High-throughput

0.536

High

969546

EXOS5
Exosome complex component RRP46

1

1

High-throughput

0.536

High

170064

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

791492

HD
Huntingtin

1

2

High-throughput

0.515

High

868434

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

969506

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.501

High

969491

SKI3
Superkiller complex protein 3

1

0

High-throughput

0.493

High

537629

NCF1
Neutrophil cytosol factor 1

1

2

High-throughput

0.489

High

427524

ANXA2
Annexin A2

1

1

Small-scale

0.481

High

969522

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

Small-scale

0.481

High

59166

VWA8
von Willebrand factor A domain-containing protein 8

1

4

High-throughput

0.479

High

63343

MET15
12S rRNA N4-methylcytidine

1

1

High-throughput

0.479

High

155334

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

227209

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

233378

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

262794

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

264893

MPPB
Mitochondrial-processing peptidase subunit beta

1

11

High-throughput

0.479

High

270025

RF1M
Peptide chain release factor 1, mitochondrial

1

7

High-throughput

0.479

High

274529

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

327420

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

2

High-throughput

0.479

High

336869

OTC
Ornithine transcarbamylase, mitochondrial

1

2

High-throughput

0.479

High

374079

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

386558

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

499697

CH60
60 kDa heat shock protein, mitochondrial

1

8

High-throughput

0.479

High

569613

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

650995

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

726160

BASI
Basigin

1

1

High-throughput

0.479

High

737313

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

751584

GRP75
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

777545

MDHM
Malate dehydrogenase, mitochondrial

1

6

High-throughput

0.479

High

789754

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

799209

EFTS
Elongation factor Ts, mitochondrial

1

3

High-throughput

0.479

High

803098

IF2M
Translation initiation factor IF-2, mitochondrial

1

5

High-throughput

0.479

High

808527

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

827346

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

842326

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.479

High

900391

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

958882

TFAM
Transcription factor A, mitochondrial

1

3

High-throughput

0.479

High

962737

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

969468

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

3

High-throughput

0.479

High

969469

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

969471

MPPA
Mitochondrial-processing peptidase subunit alpha

1

12

High-throughput

0.479

High

969473

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.479

High

969474

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

Small-scale

0.479

High

969475

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

969476

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

969478

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

969479

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

8

High-throughput

0.479

High

969481

PDK1
[Pyruvate dehydrogenase

1

8

High-throughput

0.479

High

969482

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

969485

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

969488

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.479

High

969489

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

969495

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

969496

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

8

High-throughput

0.479

High

969503

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.479

High

969507

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

3

High-throughput

0.479

High

969508

FAKD4
FAST kinase domain-containing protein 4

1

8

High-throughput

0.479

High

969509

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

969511

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

969512

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

969513

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

2

High-throughput

0.479

High

969514

RRFM
Ribosome-recycling factor, mitochondrial

1

2

High-throughput

0.479

High

969515

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

969517

AURKB
Aurora kinase B

1

2

High-throughput

0.479

High

969519

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

969520

EFGM
Elongation factor G, mitochondrial

1

4

High-throughput

0.479

High

969524

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

969526

MTG1
Mitochondrial ribosome-associated GTPase 1

1

2

High-throughput

0.479

High

969528

TR61B
tRNA

1

2

High-throughput

0.479

High

969529

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

969530

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

969533

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

7

High-throughput

0.479

High

969534

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

969535

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

969536

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

969538

MTRFR
Mitochondrial translation release factor in rescue

1

7

High-throughput

0.479

High

969539

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.479

High

969540

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

969541

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

6

High-throughput

0.479

High

969542

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.479

High

969544

NGRN
Neugrin

1

1

High-throughput

0.479

High

969548

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.479

High

969549

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

969550

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

2

High-throughput

0.479

High

969553

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

8

High-throughput

0.479

High

969554

MRES1
Mitochondrial transcription rescue factor 1

1

2

High-throughput

0.479

High

969556

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

7

High-throughput

0.479

High

969557

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

969559

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.479

High

969560

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

969498

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.470

High

503923

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

552529

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

749391

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

815233

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

868146

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

969487

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

969494

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

969510

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

969518

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

969527

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

969551

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

969552

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

199109

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

2

Small-scale

0.457

High

879105

SUMO3
Small ubiquitin-related modifier 3

1

1

Small-scale

0.445

High

969477

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

969497

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.445

High

969543

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

2

High-throughput

0.445

High

969562

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

173017

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.437

High

329654

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

384673

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

397917

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.437

High

434826

CXB1
Gap junction beta-1 protein

1

2

Small-scale

0.437

High

609257

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.437

High

720264

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

950933

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.437

High

969470

QOR
Quinone oxidoreductase

1

5

High-throughput

0.437

High

969492

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

969501

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

969521

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

969523

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

1

High-throughput

0.437

High

969525

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.437

High

969532

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.437

High

969547

ANLN
Anillin

1

1

High-throughput

0.437

High

969561

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.437

High

969537

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.426

High

302503

CE152
Centrosomal protein of 152 kDa

1

2

High-throughput

0.407

High

789261

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

969486

CP135
Centrosomal protein of 135 kDa

1

7

High-throughput

0.407

High

969493

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

1

High-throughput

0.407

High

969502

POC5
Centrosomal protein POC5

1

1

High-throughput

0.407

High

812993

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

969516

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

344970

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

969490

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

969545

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

969531

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024