Protein: PDE12
2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)

Gene: PDE12
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q6L8Q7

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000958 - mitochondrial mRNA catabolic process
GO:0004527 - exonuclease activity
GO:0004535 - poly(A)-specific ribonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475919

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

3

High-throughput

0.686

High

227775

PRKN
E3 ubiquitin-protein ligase parkin

3

3

High-throughput

0.640

High

1154278

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

262851

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

1086613

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

1154308

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

803583

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.536

High

1154282

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

509675

UBL4A
Ubiquitin-like protein 4A

1

4

High-throughput

0.515

High

737370

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

855920

ZN131
Zinc finger protein 131

1

0

High-throughput

0.513

High

1041809

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1132112

DNLZ
DNL-type zinc finger protein

1

0

High-throughput

0.513

High

1154277

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

1154280

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

1154281

RT4I1
Reticulon-4-interacting protein 1, mitochondrial

1

0

High-throughput

0.513

High

1154292

SORT
Sortilin

1

0

High-throughput

0.513

High

1154294

DHRS4
Dehydrogenase/reductase SDR family member 4

1

0

High-throughput

0.513

High

1154288

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

1

High-throughput

0.489

High

1154310

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

63377

MET15
12S rRNA N4-methylcytidine

1

1

High-throughput

0.479

High

264936

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

270055

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

322760

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

440574

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

486552

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

499833

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

777601

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

799256

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

803138

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

827434

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

958946

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

981297

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

990120

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

998813

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1014401

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1020461

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

1045781

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1050981

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

1067987

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1128154

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1140535

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1152861

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1154279

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

1154283

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1154285

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1154286

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1154289

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1154296

TR61B
tRNA

1

1

High-throughput

0.479

High

1154298

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1154299

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1154301

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1154303

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1154304

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

1154306

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1154307

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1154309

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

1154311

ARI1
E3 ubiquitin-protein ligase ARIH1

1

1

High-throughput

0.479

High

59205

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

386926

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

497184

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

651462

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

779597

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

951083

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

1035475

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1035826

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1074604

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1154284

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1154287

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1154293

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1154295

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1154297

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1154300

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1154302

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1154305

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1154314

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

552958

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

1029536

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1154312

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.437

High

1120370

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1130204

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1154313

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

1154290

INT14
Integrator complex subunit 14

1

0

High-throughput

0.279

Low

214298

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

347057

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

385006

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

720704

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

749593

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

903303

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1154275

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1154276

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1154291

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024