Protein: PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)

Gene: PNPT1
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q8TCS8

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000957 - mitochondrial RNA catabolic process
GO:0000958 - mitochondrial mRNA catabolic process
GO:0000962 - positive regulation of mitochondrial RNA catabolic process
GO:0000964 - mitochondrial RNA 5'-end processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1253751

AURKB
Aurora kinase B

1

1

High-throughput

0.691

High

1159907

FAHD1
Oxaloacetate decarboxylase, mitochondrial

3

1

High-throughput

0.667

High

1253746

FAKD4
FAST kinase domain-containing protein 4

3

3

High-throughput

0.667

High

1253773

ACAD9
Complex I assembly factor ACAD9, mitochondrial

3

0

High-throughput

0.638

High

1218848

HSC20
Iron-sulfur cluster co-chaperone protein HscB

3

0

Small-scale

0.625

High

374579

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.618

High

1017965

GRSF1
G-rich sequence factor 1

3

0

Small-scale

0.613

High

1253770

MTG2
Mitochondrial ribosome-associated GTPase 2

2

3

High-throughput

0.611

High

944868

RED1
Double-stranded RNA-specific editase 1

2

6

High-throughput

0.606

High

671088

ATPD
ATP synthase subunit delta, mitochondrial

2

0

High-throughput

0.602

High

856747

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

1071799

TMED2
Transmembrane emp24 domain-containing protein 2

2

0

High-throughput

0.602

High

1222913

SUV3
ATP-dependent RNA helicase SUPV3L1, mitochondrial

2

0

High-throughput

0.602

High

729224

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

2

0

High-throughput

0.585

High

1051021

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

1253760

TR61B
tRNA

2

0

High-throughput

0.585

High

1062249

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

2

3

Small-scale

0.571

High

262896

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1086673

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

331049

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.546

High

177520

NVL
Nuclear valosin-containing protein-like

1

2

High-throughput

0.536

High

675207

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

945301

PRR3
Proline-rich protein 3

1

1

High-throughput

0.536

High

1253783

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

388611

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

296956

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.513

High

815404

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

880315

TCL1A
T-cell leukemia/lymphoma protein 1A

1

0

High-throughput

0.513

High

1082696

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1154280

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.513

High

1240881

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1253750

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1253752

CALR3
Calreticulin-3

1

0

High-throughput

0.513

High

1253757

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1253765

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1253774

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1253780

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1253787

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1253792

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

987269

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

2

High-throughput

0.500

High

1253754

GBP4
Guanylate-binding protein 4

1

0

High-throughput

0.493

High

1253784

LRFN2
Leucine-rich repeat and fibronectin type-III domain-containing protein 2

1

3

High-throughput

0.489

High

1253791

WIF1
Wnt inhibitory factor 1

1

3

High-throughput

0.489

High

269810

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

9

High-throughput

0.481

High

228135

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

264969

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

270081

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

440635

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

499954

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

737416

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

803168

IF2M
Translation initiation factor IF-2, mitochondrial

1

12

High-throughput

0.479

High

827498

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

990195

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

998905

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1014433

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1020495

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1064512

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1128191

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1170935

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1185319

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

1253744

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

1253745

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

6

High-throughput

0.479

High

1253747

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1253755

EFGM
Elongation factor G, mitochondrial

1

6

High-throughput

0.479

High

1253759

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.479

High

1253764

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1253769

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1253771

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1253775

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

1253776

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.479

High

1253777

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

12

High-throughput

0.479

High

1253778

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

1253781

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1253782

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1253790

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

59239

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

63403

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.458

High

173068

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

327501

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

486580

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

617611

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

777648

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

789891

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

799298

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

827981

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

868635

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

951176

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

958975

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

981339

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1045809

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1068022

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1148684

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1152908

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1222196

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

1253748

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1253749

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1253758

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1253761

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1253762

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1253766

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1253767

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

1253768

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1253772

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1253779

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1253788

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1253789

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

882453

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

968628

TAGL
Transgelin

1

2

High-throughput

0.445

High

379642

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.437

High

385210

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

1253763

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

1218284

SPA12
Serpin A12

2

0

High-throughput

0.328

High

1190552

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1221401

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

1232018

CIART
Circadian-associated transcriptional repressor

1

0

High-throughput

0.279

Low

1253753

ZSC31
Zinc finger and SCAN domain-containing protein 31

1

0

High-throughput

0.279

Low

1253785

PCDA4
Protocadherin alpha-4

1

0

High-throughput

0.279

Low

1253786

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.279

Low

60165

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.269

Low

1253756

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024