Protein: PSN1
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]

Gene: PSN1, PSEN1
Organism: Homo sapiens
Interactions: 234
UniProt ID: P49768

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000776 - kinetochore
GO:0001568 - blood vessel development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

834358

PEN2
Gamma-secretase subunit PEN-2

10

7

Small-scale

0.971

High

394342

A4
Amyloid-beta precursor protein

7

2

Small-scale

0.969

High

834327

APH1A
Gamma-secretase subunit APH-1A

7

10

Small-scale

0.961

High

834243

PSN1
Presenilin-1

6

7

Small-scale

0.942

High

834244

PSN2
Presenilin-2

3

7

Small-scale

0.850

High

834321

NICA
Nicastrin

12

6

Small-scale

0.755

High

716877

CTNB1
Catenin beta-1

6

2

Small-scale

0.732

High

521809

CADH1
Cadherin-1

5

5

Small-scale

0.712

High

834375

TRAF6
TNF receptor-associated factor 6

4

1

Small-scale

0.683

High

834245

GSK3B
Glycogen synthase kinase-3 beta

4

1

Small-scale

0.680

High

834370

UBQL1
Ubiquilin-1

3

3

Small-scale

0.667

High

594481

PSB1
Proteasome subunit beta type-1

2

6

Small-scale

0.644

High

656175

PSA5
Proteasome subunit alpha type-5

2

3

Small-scale

0.644

High

239081

CTND1
Catenin delta-1

2

5

Small-scale

0.631

High

834269

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

2

4

Small-scale

0.629

High

834251

CADH8
Cadherin-8

2

5

High-throughput

0.628

High

834319

HUMMR
Protein MGARP

2

1

High-throughput

0.621

High

489385

BCL2
Apoptosis regulator Bcl-2

2

4

Small-scale

0.620

High

833177

TMEDA
Transmembrane emp24 domain-containing protein 10

2

1

Small-scale

0.618

High

834320

APH1B
Gamma-secretase subunit APH-1B

1

10

Small-scale

0.618

High

299865

ERLN2
Erlin-2

2

1

Small-scale

0.611

High

834318

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

834341

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.599

High

804171

NOTC1
Neurogenic locus notch homolog protein 1

2

11

Small-scale

0.595

High

834336

PKP4
Plakophilin-4

1

5

Small-scale

0.586

High

349977

RASK
GTPase KRas

2

3

High-throughput

0.584

High

834374

CSEN
Calsenilin

2

4

Small-scale

0.584

High

834296

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.580

High

834325

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.576

High

261225

FLNB
Filamin-B

1

5

Small-scale

0.573

High

834369

ICAM5
Intercellular adhesion molecule 5

1

2

Small-scale

0.573

High

598012

FLNA
Filamin-A

2

5

Small-scale

0.565

High

834285

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

2

0

Small-scale

0.559

High

834283

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

Small-scale

0.552

High

591461

RAB3A
Ras-related protein Rab-3A

1

1

High-throughput

0.541

High

130799

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.536

High

156254

PSA7
Proteasome subunit alpha type-7

1

3

High-throughput

0.536

High

234104

FADS1
Acyl-CoA

1

1

High-throughput

0.536

High

243335

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.536

High

326862

FADS2
Acyl-CoA 6-desaturase

1

1

High-throughput

0.536

High

501835

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

637650

PSA2
Proteasome subunit alpha type-2

1

4

High-throughput

0.536

High

638087

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.536

High

656683

PSB5
Proteasome subunit beta type-5

1

3

High-throughput

0.536

High

681371

DNJA1
DnaJ homolog subfamily A member 1

1

3

High-throughput

0.536

High

686271

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.536

High

776080

ARL1
ADP-ribosylation factor-like protein 1

1

1

High-throughput

0.536

High

792748

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

803437

BAG6
Large proline-rich protein BAG6

1

3

High-throughput

0.536

High

809877

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.536

High

823023

AGRE5
Adhesion G protein-coupled receptor E5

1

1

High-throughput

0.536

High

832072

PSB2
Proteasome subunit beta type-2

1

4

High-throughput

0.536

High

834252

CAD12
Cadherin-12

1

5

High-throughput

0.536

High

834257

PSA6
Proteasome subunit alpha type-6

1

4

High-throughput

0.536

High

834259

TSN5
Tetraspanin-5

1

1

High-throughput

0.536

High

834270

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

2

High-throughput

0.536

High

834289

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.536

High

834292

CP51A
Lanosterol 14-alpha demethylase

1

2

High-throughput

0.536

High

834328

FAF2
FAS-associated factor 2

1

1

High-throughput

0.536

High

834335

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.536

High

834337

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.536

High

834363

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.536

High

834376

SRPRB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.536

High

834246

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.531

High

834264

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.530

High

834288

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.530

High

834359

TREM2
Triggering receptor expressed on myeloid cells 2

1

0

Small-scale

0.530

High

834254

BACE1
Beta-secretase 1

1

0

Small-scale

0.519

High

316311

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.518

High

361457

APOE
Apolipoprotein E

1

0

High-throughput

0.518

High

834267

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.518

High

834300

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

0

High-throughput

0.518

High

834332

PRAM
PML-RARA-regulated adapter molecule 1

1

0

High-throughput

0.518

High

197888

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

Small-scale

0.515

High

59944

A4FUJ8
MKL1 protein

1

1

High-throughput

0.515

High

124657

TR11B
Tumor necrosis factor receptor superfamily member 11B

1

1

High-throughput

0.515

High

364846

FRIL
Ferritin light chain

1

1

High-throughput

0.515

High

834249

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.515

High

834262

AP2B1
AP-2 complex subunit beta

1

1

High-throughput

0.515

High

834266

H31
Histone H3.1

1

1

High-throughput

0.515

High

834277

PDZ1I
PDZK1-interacting protein 1

1

1

High-throughput

0.515

High

834295

SGSM1
Small G protein signaling modulator 1

1

1

High-throughput

0.515

High

834313

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.515

High

834331

ZMAT2
Zinc finger matrin-type protein 2

1

1

High-throughput

0.515

High

834347

SKI8
Superkiller complex protein 8

1

3

High-throughput

0.515

High

834378

MOFA1
MORF4 family-associated protein 1

1

1

High-throughput

0.515

High

123542

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

136156

SCD
Stearoyl-CoA desaturase

1

0

High-throughput

0.513

High

158093

TX1B3
Tax1-binding protein 3

1

0

High-throughput

0.513

High

168246

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.513

High

180249

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.513

High

199299

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

202843

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.513

High

213112

SNG1
Synaptogyrin-1

1

0

High-throughput

0.513

High

245322

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

323641

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

328314

S1PR4
Sphingosine 1-phosphate receptor 4

1

0

High-throughput

0.513

High

388308

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.513

High

390775

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

503687

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

561527

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

High-throughput

0.513

High

572896

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.513

High

574623

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.513

High

725735

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

730216

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.513

High

762929

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

790711

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

795071

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.513

High

801654

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.513

High

834247

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.513

High

834248

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.513

High

834255

TMM33
Transmembrane protein 33

1

0

High-throughput

0.513

High

834256

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

834268

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

834273

SIA4A
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

1

0

High-throughput

0.513

High

834274

TBL3
Transducin beta-like protein 3

1

0

High-throughput

0.513

High

834276

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

0

High-throughput

0.513

High

834278

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.513

High

834281

MLEC
Malectin

1

0

High-throughput

0.513

High

834284

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.513

High

834286

PCBP2
Poly(rC)-binding protein 2

1

0

High-throughput

0.513

High

834293

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

834298

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.513

High

834304

RHBD2
Rhomboid domain-containing protein 2

1

0

High-throughput

0.513

High

834309

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.513

High

834310

P2RY8
P2Y purinoceptor 8

1

0

High-throughput

0.513

High

834312

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

834314

SERP2
Stress-associated endoplasmic reticulum protein 2

1

0

High-throughput

0.513

High

834315

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.513

High

834317

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.513

High

834324

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.513

High

834342

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.513

High

834343

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

834350

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

834352

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.513

High

834354

SAR1A
Small COPII coat GTPase SAR1A

1

0

High-throughput

0.513

High

834362

HACD3
Very-long-chain

1

0

High-throughput

0.513

High

834364

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.513

High

834366

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.513

High

834368

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.513

High

834371

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.513

High

834377

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

834272

B2CL1
Bcl-2-like protein 1

1

4

Small-scale

0.508

High

834372

CTND2
Catenin delta-2

1

5

Small-scale

0.506

High

542237

PLAK
Junction plakoglobin

1

3

Small-scale

0.501

High

834322

RYR2
Ryanodine receptor 2

1

1

Small-scale

0.501

High

834338

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

4

Small-scale

0.501

High

834280

DSG2
Desmoglein-2

1

6

Small-scale

0.500

High

834316

DNER
Delta and Notch-like epidermal growth factor-related receptor

1

11

Small-scale

0.500

High

726084

BASI
Basigin

1

0

Small-scale

0.494

High

146078

PLPP1
Phospholipid phosphatase 1

1

0

High-throughput

0.493

High

562465

CBPE
Carboxypeptidase E

1

0

High-throughput

0.493

High

834271

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.493

High

834275

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.493

High

834301

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.493

High

834307

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.493

High

834330

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

834340

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

834346

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.493

High

834351

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.493

High

834367

RN112
RING finger protein 112

1

0

High-throughput

0.493

High

213717

ENSA
Alpha-endosulfine

1

0

High-throughput

0.486

High

381860

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.486

High

505712

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.486

High

521500

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.486

High

618022

COF1
Cofilin-1

1

0

High-throughput

0.486

High

834253

SCOT1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

1

0

High-throughput

0.486

High

834334

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.486

High

834344

EFHD1
EF-hand domain-containing protein D1

1

0

High-throughput

0.486

High

834373

E41L3
Band 4.1-like protein 3

1

0

High-throughput

0.486

High

649377

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.484

High

535349

GFAP
Glial fibrillary acidic protein

1

1

Small-scale

0.481

High

449606

HMGB1
High mobility group protein B1

1

1

High-throughput

0.481

High

496139

CP2C8
Cytochrome P450 2C8

1

1

High-throughput

0.481

High

667666

NOS3
Nitric oxide synthase 3

1

1

High-throughput

0.481

High

703519

CP2CI
Cytochrome P450 2C18

1

1

High-throughput

0.481

High

834250

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.481

High

834287

RHEB
GTP-binding protein Rheb

1

2

High-throughput

0.481

High

834297

PDCD4
Programmed cell death protein 4

1

2

High-throughput

0.481

High

834305

KCIP4
Kv channel-interacting protein 4

1

4

Small-scale

0.481

High

834339

CIB1
Calcium and integrin-binding protein 1

1

4

Small-scale

0.481

High

834348

RNF32
RING finger protein 32

1

1

High-throughput

0.481

High

800861

MK09
Mitogen-activated protein kinase 9

1

0

Small-scale

0.480

High

555059

ANPRA
Atrial natriuretic peptide receptor 1

1

0

Small-scale

0.479

High

834279

DAG1
Dystroglycan 1

1

0

Small-scale

0.479

High

834302

VASN
Vasorin

1

0

Small-scale

0.479

High

834306

PXDC2
Plexin domain-containing protein 2

1

0

Small-scale

0.479

High

302379

CSTN1
Calsyntenin-1

1

3

Small-scale

0.479

High

348574

RASN
GTPase NRas

1

3

High-throughput

0.479

High

349191

RASH
GTPase HRas

1

3

High-throughput

0.479

High

580211

CADH2
Cadherin-2

1

6

Small-scale

0.479

High

834261

GRB2
Growth factor receptor-bound protein 2

1

1

Small-scale

0.479

High

834290

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.479

High

834294

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

834326

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.479

High

834353

TF7L2
Transcription factor 7-like 2

1

1

Small-scale

0.479

High

834357

DJB12
DnaJ homolog subfamily B member 12

1

2

High-throughput

0.479

High

390123

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.464

High

533429

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

Small-scale

0.460

High

685642

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.460

High

723841

SCN1A
Sodium channel protein type 1 subunit alpha

1

0

High-throughput

0.460

High

834323

FGF13
Fibroblast growth factor 13

1

0

High-throughput

0.460

High

834329

STALP
AMSH-like protease

1

0

High-throughput

0.460

High

834333

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

Small-scale

0.460

High

834361

ITSN2
Intersectin-2

1

0

High-throughput

0.460

High

834379

AP1M2
AP-1 complex subunit mu-2

1

0

High-throughput

0.460

High

265504

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

Small-scale

0.458

High

475489

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

557365

BGAL
Beta-galactosidase

1

0

High-throughput

0.458

High

716629

CTNA1
Catenin alpha-1

1

0

Small-scale

0.458

High

723238

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

0

Small-scale

0.458

High

738511

TGFR1
TGF-beta receptor type-1

1

0

Small-scale

0.458

High

834303

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

834349

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

834360

MTCH1
Mitochondrial carrier homolog 1

1

0

Small-scale

0.458

High

834356

FXL12
F-box/LRR-repeat protein 12

1

1

High-throughput

0.439

High

203891

HTRA2
Serine protease HTRA2, mitochondrial

1

0

Small-scale

0.438

High

834260

RB11A
Ras-related protein Rab-11A

1

0

Small-scale

0.438

High

59531

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.437

High

505523

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

0

Small-scale

0.426

High

528778

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

570250

NEUM
Neuromodulin

1

0

Small-scale

0.426

High

834258

STXB1
Syntaxin-binding protein 1

1

0

Small-scale

0.426

High

834282

FLOT2
Flotillin-2

1

0

Small-scale

0.426

High

834291

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.308

High

834263

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.279

Low

834299

DALD3
DALR anticodon-binding domain-containing protein 3

1

0

High-throughput

0.268

Low

834311

OOSP2
Oocyte-secreted protein 2

1

0

High-throughput

0.268

Low

834345

KRA92
Keratin-associated protein 9-2

1

0

High-throughput

0.268

Low

834355

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.268

Low

834365

FEZ2
Fasciculation and elongation protein zeta-2

1

0

High-throughput

0.268

Low

834265

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.251

Low

834308

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024